Results 71 to 80 of about 62,922 (266)

Bacterial Extracellular Vesicles in the Pathogenesis and Treatment of Liver Diseases

Journal of Gastroenterology and Hepatology, EarlyView.
Liver diseases are a major global health challenge, with current treatments inadequate. This review highlights the role of bacterial extracellular vesicles in liver inflammation, fibrosis, and metabolism. We also explore these from commensals and probiotics, their protective effects, and discuss research challenges and future therapeutic potential ...
Yakun Li, Jia Li, Robin P. F. Dullaart, Han Moshage   +3 more
wiley   +1 more source

Autoimmunity and Periodontitis

Journal of Periodontal Research, EarlyView.
In a microbe‐driven inflammatory environment, peptidyl‐arginine deiminase (PAD) enzymes from neutrophils and Porphyromonas gingivalis citrullinate both microbial and self‐antigens. B cell presentation of citrullinated or self‐mimicking epitopes activates T cells that assist B cells in antibody isotype switching, affinity maturation, epitope spreading ...
Massimo Costalonga, Vivek Thumbigere‐Math, Mark C. Herzberg   +2 more
wiley   +1 more source

Nitric Oxide Measurements during Endotoxemia [PDF]

Clinical Chemistry, 2001
Abstract Background: Excessive continuous NO release from inducible NO synthase over prolonged periods under pathological conditions, such as endotoxemia, contributes significantly to circulatory failure, hypotension, and septic shock. This NO production during endotoxemia is accompanied by superoxide release, which contributes to the ...
V, Brovkovych, L W, Dobrucki, S, Brovkovych, I, Dobrucki, L, Kalinowski, F, Kiechle, T, Malinski   +6 more
openaire   +2 more sources

Attenuation of leukocyte sequestration by selective blockade of PECAM-1 or VCAM-1 in murine endotoxemia [PDF]

, 2004
Background: Molecular mechanisms regulating leukocyte sequestration into the tissue during endotoxemia and/or sepsis are still poorly understood. This in vivo study investigates the biological role of murine PECAM-1 and VCAM-1 for leukocyte sequestration
Chosay JG, Chosay JG, Christofidou-Solomidou M, D. Nolte, Dinarello CA, Essani NA, Hahne M, Hoffmann JN, Jin HK, K. Messmer, K.-D. Wolff, Khan BV, Kuebler WM, Kunkel EJ, Muchamuel T, Neumann B, Nolte D, Nolte D, Nolte D, Orosz CG, Piedboeuf B, Vaporciyan AA, Vestweber D, W.A. Muller, W.M. Kuebler, Zeintl H   +25 more
core   +1 more source

CD36 and Its Role in Obesity

Obesity Reviews, EarlyView.
ABSTRACT Obesity is understood as a condition driven by interactions between genetics and environmental factors. The role of CD36 in the regulation of lipid metabolism and ectopic fat accumulation emerges as a key area of interest. This review presents CD36 not only as a crucial facilitator of fatty acid uptake but also as a regulator of how and where ...
Nahuel Garcia, Maiken Mellergaard, Carlos Salomon, Pilar Sepulveda, Peter Kristensen, Aase Handberg   +5 more
wiley   +1 more source

Antrodia cinnamomea reduces obesity and modulates the gut microbiota in high-fat diet-fed mice. [PDF]

, 2018
BackgroundObesity is associated with gut microbiota dysbiosis, disrupted intestinal barrier and chronic inflammation. Given the high and increasing prevalence of obesity worldwide, anti-obesity treatments that are safe, effective and widely available ...
Chang, C-J, Ko, Y-F, Lai, H-C, Lin, C-S, Lu, C-C, Lu, J-J, Martel, J, Ojcius, DM, Tsai, Y-H, Wu, T-R, Yeh, T-S, Young, JD   +11 more
core  

Extracellular ATP drives systemic inflammation, tissue damage and mortality [PDF]

, 2014
Systemic inflammatory response syndromes (SIRS) may be caused by both infectious and sterile insults, such as trauma, ischemia-reperfusion or burns. They are characterized by early excessive inflammatory cytokine production and the endogenous release of ...
Brouckaert, Peter, Cauwels, Anje, Rogge, Elke, Shiva, S, Vandendriessche, Benjamin   +4 more
core   +1 more source

Pre‐diagnostic immunological markers of bacterial translocation and liver cancer risk: A nested case–control analysis of 12 prospective cohorts

International Journal of Cancer, Volume 158, Issue 7, Page 1801-1812, 1 April 2026.
What's new? Disruption of the gut–liver axis has been suggested to play an important role in liver carcinogenesis. However, limited prospective research has explored associations between potentially harmful gut‐derived bacterial products and liver cancer risk.
Cody Z. Watling, Peter T. Campbell, Barry I. Graubard, Yanyu Wang, Andrew T. Gewirtz, Xuehong Zhang, Matthew J. Barnett, Julie E. Buring, Yu Chen, A. Heather Eliassen, J. Michael Gaziano, Jonathan N. Hofmann, Wen‐Yi Huang, Jae H. Kang, Jill Koshiol, Erikka Loftfield, I‐Min Lee, Steven C. Moore, Lorelei A. Mucci, Marian L. Neuhouser, Christina C. Newton, Mark P. Purdue, Howard D. Sesso, Martha Shrubsole, Rashmi Sinha, Lesley Tinker, Matthew Triplette, Caroline Y. Um, Kala Visvanathan, Eleanor L. Watts, Jean Wactawski‐Wende, Walter Willett, Fen Wu, Wei Zheng, Dinesh Barupal, Jessica L. Petrick, Katherine A. McGlynn   +36 more
wiley   +1 more source

Effects of diclofenac and dexamethasone on horse experimental endotoxemia Efeitos do diclofenaco e da dexametasona na endotoxemia experimental em eqüinos

Arquivo Brasileiro de Medicina Veterinária e Zootecnia, 2003
Fifteen healthy Mangalarga horses, aged two to three years were used to evaluate the possible beneficial effects of dexamethasone and sodium diclofenac administration during experimental endotoxemia in horses.
P.C.S. Rosa, J.R. Peiró, R.C. Campebell, C.A.A. Valadão, G.H. Bechara   +4 more
doaj   +1 more source

Y-RNA subtype ratios in plasma extracellular vesicles are cell type- specific and are candidate biomarkers for inflammatory diseases

Journal of Extracellular Vesicles, 2020
Major efforts are made to characterize the presence of microRNA (miRNA) and messenger RNA in blood plasma to discover novel disease-associated biomarkers.
Tom A.P. Driedonks, Sanne Mol, Sanne de Bruin, Anna-Linda Peters, Xiaogang Zhang, Marthe F.S. Lindenbergh, Boukje M. Beuger, Anne-Marieke D. van Stalborch, Thom Spaan, Esther C. de Jong, Erhard van der Vries, Coert Margadant, Robin van Bruggen, Alexander P.J. Vlaar, Tom Groot Kormelink, Esther N.M. Nolte-‘T Hoen   +15 more
doaj   +1 more source