Toll-like receptor 4 mediates synergism between alcohol and HCV in hepatic oncogenesis involving stem cell marker Nanog [PDF]
, 2009 Alcohol synergistically enhances the progression of liver disease and the risk for liver cancer caused by hepatitis C virus (HCV). However, the molecular mechanism of this synergy remains unclear.
Asahina, Kinji +13 more
core +2 more sources
Resident Macrophage Nitrogen Oxide Production Regulates Ozone Exacerbation of Acute Lung Injury Following Endotoxemia [PDF]
, 2020 Rajeev Rajagopal +8 more
openalex +1 more source
Butyrate ameliorates alcoholic fatty liver disease via reducing endotoxemia and inhibiting liver gasdermin D-mediated pyroptosis [PDF]
, 2021 Ting Zhang +7 more
openalex +1 more source
Clinical Pharmacology &Therapeutics, Volume 119, Issue 3, Page 678-687, March 2026.Vascular leakage and its associated phenomena vasodilation and endothelial activation are pathophysiological features of various diseases. Multiple drug candidates targeting these phenomena are in development, necessitating translational models to demonstrate proof‐of‐pharmacology and proof‐of‐mechanism in early‐phase clinical trials.
Marella Cornelia Elizabeth van Ruissen +10 more
wiley +1 more source
Frontiers in Immunology, 2019 Defensins have attracted considerable research interest worldwide because of their potential to serve as a substitute for antibiotics. In this study, we characterized a novel porcine β-defensin (pBD129) and explored its role in alleviating bacterial ...
Kunhong Xie +22 more
doaj +1 more source
High fat diet causes depletion of intestinal eosinophils associated with intestinal permeability. [PDF]
, 2015 The development of intestinal permeability and the penetration of microbial products are key factors associated with the onset of metabolic disease. However, the mechanisms underlying this remain unclear. Here we show that, unlike liver or adipose tissue,
Armando, Aaron M +6 more
core +2 more sources
Endotoxemia in Acute Heart Failure and Cardiogenic Shock: Evidence, Mechanisms and Therapeutic Options [PDF]
, 2023 Maxime Nguyen +4 more
openalex +1 more source
Perinatal Gut Dysbiosis Reduces Milk Oligosaccharides via LPS‐Mediated Gut–Mammary Signaling in Mice
Food Frontiers, Volume 7, Issue 2, March 2026.Maternal gut dysbiosis elevates Gram‐negative bacterial lipopolysaccharide (LPS), which enters circulation and accumulates in mammary tissue. This compromises the blood–milk barrier and suppresses key enzymatic genes, ultimately reducing milk oligosaccharide synthesis and potentially affecting neonatal gut microbiota through breastfeeding.
Man‐Lin Zhou +9 more
wiley +1 more source
Risk factors and prognostic value of endotoxemia in patients with acute myocardial infarction
Frontiers in Cardiovascular MedicineBackgroundThere is increasing evidence regarding the association between endotoxemia and the pathogenesis of atherosclerosis and myocardial infarction (MI).
Maxime Nguyen +18 more
doaj +1 more source
Simvastatin improves survival and reduces leukocyte recruitment and hepatocyte apoptosis in endotoxin-induced liver injury [PDF]
Scripta Medica, 2011 BACKGROUND. Endotoxemia provokes excessive host response to bacteria or microbial compounds, resulting in systemic inflammation, organ injury and mortality.
Nežić Lana +7 more
doaj