Results 241 to 250 of about 2,705,124 (338)

Functional Integration of Different‐Sex Gonad Transplants Into the Adult Mouse Hypothalamic Pituitary Gonadal Axis

Advanced Biology, EarlyView.
This study introduces and investigates different‐sex gonad transplants in a mouse model of gender‐affirming hormone therapy. Ovaries and testes implanted into gonadectomized adults exhibit gametogenesis and steroidogenesis independent of the sex of the host.
Daniel R. Pfau, Monica A. Rionda, Evelyn Cho, Jamison G. Clark, Robin E. Kruger, Ruth K. Chan‐Sui, Vasantha Padmanabhan, Molly B. Moravek, Ariella Shikanov   +8 more
wiley   +1 more source

Primary Human Tissue Models for Metabolic Dysfunction‐Associated Liver Disease ‐ toward Streamlining Drug Discovery with Patient‐Derived Assays

Advanced Biology, EarlyView.
The review provides a critical up‐to‐date overview of the current landscape of human in vitro models for fatty liver disease, including spheroids, organoids, organ‐on‐a‐chip systems, bioprinted liver constructs and precision‐cut liver slices. Their utility for faithfully modeling different stages of MASLD and MASH are evaluated and their compatibility ...
Sonia Youhanna, Nayere Taebnia, Yingxin Liang, Ningtao Cheng, Yi Wang, Maurice Michel, Volker M. Lauschke   +6 more
wiley   +1 more source

Statistical analysis plan for TTVguideIT-a multicentre, patient- and assessor-blinded, non-inferiority, randomised and controlled phase II trial to compare standard and Torque Teno virus-guided immunosuppression in kidney transplant recipients in the first year after transplantation. [PDF]

Trials
Herkner F, Haupenthal F, Kapps S, Doberer K, Herkner H, König F, Bond G.   +6 more
europepmc   +1 more source

A Spatially Resolved View on the Aging Substantia nigra: An Exploratory Proteomic Study

Advanced Biology, EarlyView.
Although aging is the most important risk factor for several neurodegenerative diseases, the molecular effects of physiological aging are still understudied. By applying spatially‐resolved proteomic analyses of the human substantia nigra pars compacta, alterations in vesicular trafficking and mitochondrial proteins are observed, as well as reduced ...
Britta Eggers, Maximilian Hausherr, Michel Lim, Karin Schork, Bilhan Karacora, Robin Grugel, Martin Eisenacher, Isabel Gil Aldea, Peter Riederer, Manfred Gerlach, Katrin Marcus   +10 more
wiley   +1 more source

Osteocytes under Mechanical Loading Regulate PC‐3 Cancer Cell–Mineral Interactions during Early‐Stage Metastasis to Bone

Advanced Biology, EarlyView.
In this study, Seaman et al. develop a co‐culture assay to examine interactions between prostate cancer cells and mineralized osteoblasts in a microfluidic platform. The authors collect conditioned media from static or flow‐stimulated osteocytes and demonstrate that mechanical loading of osteocytes regulates the growth of prostate cancer cells and ...
Kimberly Seaman, Bryan Guo, William W. Du, Burton Yang, Yu Sun, Lidan You   +5 more
wiley   +1 more source

Benchmark Response (BMR) Values for In Vivo Mutagenicity Endpoints. [PDF]

Environ Mol Mutagen
White PA, Chen G, Chepelev N, Bell MA, Gallant LR, Johnson GE, Zeller A, Beal MA, Long AS.   +8 more
europepmc   +1 more source

Engineering the Link: From Genome Interaction Maps to Functional Insight

Advanced Biology, EarlyView.
Advances in chromosome conformation capture have revealed the genome's 3D organization, yet its causal impact on gene regulation remains elusive. This review highlights emerging genome‐engineering tools ‐ zinc fingers, TALEs, and CRISPR‐Cas9 ‐ that enable targeted manipulation of chromatin loops to dissect structure–function relationships. It discusses
Frido Petersen, Simon Westermann, Valeriia Smialkovska, Jan Mathony, Angelika Feldmann, Dominik Niopek   +5 more
wiley   +1 more source

Redefining endpoints in heart failure clinical trials: the emerging role of wearable technologies in contemporary trial design. [PDF]

Heart Fail Rev
Alawoad Z, Jensen J, Schou M, Ahmed N, Attia A, Rao S, Rahimi K, Wamil M.   +7 more
europepmc   +1 more source

Numerical Model and Experimental Validation of Composite Metal Foam in Protecting Carbon Steel Against Puncture

Advanced Engineering Materials, EarlyView.
The puncture prevention and energy absorption performance of composite metal foam (CMF) are studied experimentally and numerically for hazardous materials transportation protection. The numerical model implementing air within the CMF (nonhomogeneous model using fluid cavity technique) predicts puncture more accurately compared to the homogeneous CMF ...
Aman Kaushik, Afsaneh Rabiei
wiley   +1 more source

Adjudication of cause of death in older adults: Learnings for death certification from the ASPirin in Reducing Events in the Elderly study. [PDF]

Clin Trials
Nelson MR, McNeil JJ, Stocks N, Panjwani S, Shah RC.   +4 more
europepmc   +1 more source