Results 71 to 80 of about 176,455 (318)

Cardiac magnetic resonance imaging versus computed tomography to guide transcatheter aortic valve replacement: study protocol for a randomized trial (TAVR-CMR)

Trials, 2022
Background The standard procedure for the planning of transcatheter aortic valve replacement (TAVR) is the combination of echocardiography, coronary angiography, and cardiovascular computed tomography (TAVR-CT) for the exact determination of the aortic ...
Gert Klug, Sebastian Reinstadler, Felix Troger, Magdalena Holzknecht, Martin Reindl, Christina Tiller, Ivan Lechner, Priscilla Fink, Mathias Pamminger, Christian Kremser, Hanno Ulmer, Axel Bauer, Bernhard Metzler, Agnes Mayr   +13 more
doaj   +1 more source

Peptide‐based ligand antagonists block a Vibrio cholerae adhesin

FEBS Letters, EarlyView.
The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang, Grace Du, Charity Yongo‐Luwawa, Angelina Lu, Brett Kinrade, Kim Munro, Karl E. Klose, William D. Lubell, Peter Davies, Shuaiqi Guo   +9 more
wiley   +1 more source

An alternative trial-level measure for evaluating failure-time surrogate endpoints based on prediction error

Contemporary Clinical Trials Communications, 2019
To validate a failure-time surrogate for an established failure-time clinical endpoint such as overall survival, the meta-analytic approach is commonly used.
Shaima Belhechmi, Stefan Michiels, Xavier Paoletti, Federico Rotolo   +3 more
doaj   +1 more source

Heat Flux Analysis and Assessment of Drying Kinetics during Lyophilization of Fruits in a Pilot-Scale Freeze Dryer

Foods, 2023
Vacuum freeze-drying as a process for achieving high product quality has attracted increasing attention in the last decade. Particularly in the pharmaceutical field and food processing industries, lyophilization can produce high-quality products compared
Ivan Sedmak, Matic Može, Gorazd Kambič, Iztok Golobič   +3 more
doaj   +1 more source

Mass measurements near the $r$-process path using the Canadian Penning Trap mass spectrometer

, 2012
The masses of 40 neutron-rich nuclides from Z = 51 to 64 were measured at an average precision of $\delta m/m= 10^{-7}$ using the Canadian Penning Trap mass spectrometer at Argonne National Laboratory. The measurements, of fission fragments from a $^{252}
A. Chaudhuri, A. F. Levand, B. J. Zabransky, D. Lascar, E. Sugarbaker, G. Li, G. Savard, I. F. Barchuk, J. A. Clark, J. Fallis, J. P. Greene, J. Van Schelt, K. S. Sharma, K.-L. Kratz, M. G. Sternberg, M. Shibata, M. W. Chase, S. Caldwell, T. Sun, U. Keyser   +19 more
core   +1 more source

Supersymmetry, Naturalness, and Signatures at the LHC [PDF]

, 2006
Weak scale supersymmetry is often said to be fine-tuned, especially if the matter content is minimal. This is not true if there is a large A term for the top squarks.
A. Brignole, R. Barbieri, Ryuichiro Kitano, T. Kobayashi, Yasunori Nomura   +4 more
core   +3 more sources

Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer

FEBS Letters, EarlyView.
Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani, Noemi E. Nwosu, Viktoria Gocke, Müge Kasanmascheff, Hannes Mutschler   +4 more
wiley   +1 more source

Challenges in translating end points from trials to observational cohort studies in oncology

Clinical Epidemiology, 2016
Anne Gulbech Ording,1 Deirdre Cronin-Fenton,1 Vera Ehrenstein,1 Timothy L Lash,1,2 John Acquavella,1 Mikael Rørth,1 Henrik Toft Sørensen1 1Department of Clinical Epidemiology, Aarhus University Hospital, Aarhus, Denmark; 2Department of&
Ording AG, Cronin-Fenton D, Ehrenstein V, Lash TL, Acquavella J, Rørth M, Sørensen HT   +6 more
doaj  

International Laboratory Comparison of Influenza Microneutralization Assays for A(H1N1) pdm09, A(H3N2), and A(H5N1) Influenza Viruses by CONSISE [PDF]

, 2015
The microneutralization assay is commonly used to detect antibodies to influenza virus, and multiple protocols are used worldwide. These protocols differ in the incubation time of the assay as well as in the order of specific steps, and even within ...
Engelhardt, OG, Heath, A, Hoschler, K, Hungnes, O, Katz, JM, Laurie, KL, Peiris, M, Van Kerkhove, MD, Wood, J, Zhang, W   +9 more
core   +1 more source

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source