Results 61 to 70 of about 313,385 (288)

Emerging risk factors and the dose-response relationship between physical activity and lone atrial fibrillation: a prospective case-control study [PDF]

, 2017
A history of a parts per thousand yen2000 h of vigorous endurance training, tall stature, abdominal obesity, and OSA are frequently encountered as risk factors in patients with Ln-AF.
Berruezo Sánchez, Antonio, Bisbal, Felipe, Borràs, Roger, Brugada Terradellas, Josep, 1958-, Calvo Galiano, Naiara, Coca, Antonio, Coll-Vinent i Puig, Blanca, Doménech, Mónica, Embid, Cristina, Falces Salvador, Carles, Guasch i Casany, Eduard, Hevia, Sara, Mont Girbau, Lluís, Montserrat Canal, José Ma., Montserrat-Vila, Sílvia, Ramos, Pablo, Sitges Carreño, Marta, Vidorreta, Silvia   +17 more
core   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Optimizing Arm Muscle Endurance in Pencak Silat Athletes: Insights from a Literature Review

Tanjungpura Journal of Coaching Research
Background and Study Aim. Pencak Silat is a martial art that demands exceptional physical strength, agility, and endurance. Among these, arm muscle endurance plays an important role in performing effective offensive and defensive maneuvers. Improving arm
Jefrio Demitrimus Nubatonis, Sulistiyono Sulistiyono, Muhamad Husein, Irvan Septianto, Salmon Runesi, Dwi Manna Nazmi Zakiah, Julian Dewantara, Jihan Azrina, Syahrizal Islam, Vince Louisse D. Salacup   +9 more
doaj   +1 more source

Characterizing the salivary RNA landscape to identify potential diagnostic, prognostic, and follow‐up biomarkers for breast cancer

Molecular Oncology, EarlyView.
This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan, Irina Primac, Emre Etlioglu, Laurens Debruyne, Ann Janssen, Magy Sallam, Kevin Tabury, Roel Quintens, Wiebren Tjalma, Mohammed Abderrafi Benotmane   +9 more
wiley   +1 more source

Efficacy of an 8-Week Concurrent Strength and Endurance Training Programme on Hand Cycling Performance [PDF]

, 2018
The aim of the present study was to investigate the effects of an 8-week concurrent strength and endurance training programme in comparison to endurance training only on several key determinants of hand cycling performance. Five H4 and five H3 classified
Blagrove, R., Hunt, A., Nevin, J., Patterson, S., Price, M., Smith, Paul M., Waldron, M.   +6 more
core   +2 more sources

Gut microbiota diversity is prognostic in metastatic hormone receptor‐positive breast cancer patients receiving chemotherapy and immunotherapy

Molecular Oncology, EarlyView.
In this exploratory study, we investigated the relationship between the gut microbiota and outcome in patients with metastatic hormone receptor‐positive breast cancer, treated in a randomized clinical trial with chemotherapy alone or chemotherapy in combination with immune checkpoint blockade.
Andreas Ullern, Kristian Holm, Nikolai Kragøe Andresen, Andreas Hagen Røssevold, Corinna Bang, Bjørn Naume, Johannes R. Hov, Jon Amund Kyte   +7 more
wiley   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

The Effect of Endurance Training on Brain-Derived Neurotrophic Factor and Inflammatory Markers in Healthy People and Parkinson's Disease. A Narrative Review

Frontiers in Physiology, 2020
Background: One purpose of the training conducted by people is to lose bodyweight and improve their physical condition. It is well-known that endurance training provides many positive changes in the body, not only those associated with current beauty ...
Paulina Małczyńska-Sims, Małgorzata Chalimoniuk, Anna Sułek   +2 more
doaj   +1 more source

Changes in lower limb muscle function and muscle mass following exercise-based interventions in patients with chronic obstructive pulmonary disease : a review of the English-language literature [PDF]

, 2017
Chronic obstructive pulmonary disease (COPD) patients often experience lower limb muscle dysfunction and wasting. Exercise-based training has potential to improve muscle function and mass, but literature on this topic is extensive and heterogeneous ...
Burtin, Chris, De Brandt, Jana, Derave, Wim, Franssen, Frits ME, Hansen, Dominique, Sillen, Maurice JH, Spruit, Martijn A   +6 more
core   +2 more sources