Results 41 to 50 of about 80,523 (260)

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Effect of Endurance Training on miR-196a and miR-133a Expression in Subcutaneous White Adipose Tissue of Wistar Rats [PDF]

فیزیولوژی ورزش و فعالیت بدنی, 2019
Purpose: The aim of current study was to investigate the effect of endurance training on expression of miR-196a and miR-133a in subcutaneous white adipose tissue (WAT). Methods: 16 wistar rats were divided into two groups included: 1) Control (n=8) and 2)
Saeed Daneshyar, Mohammad Reza Kordi, Mehdi Kadivar, Samane Afshari   +3 more
doaj   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Longitudinal genome‐wide aneuploidy measurements in circulating cell‐free DNA to predict lack of benefit from pembrolizumab in patients with metastatic urothelial cancer

Molecular Oncology, EarlyView.
Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi, Stavros Makrodimitris, Sandra van Wilpe, Iris te Paske, Vanja de Weerd, Corine M. Beaufort, Hans M. Westgeest, Jens Voortman, Maureen J. B. Aarts, Maud Rijnders, Astrid A. M. van der Veldt, Ronald de Wit, Niven Mehra, Saskia M. Wilting, Debbie G. J. Robbrecht   +14 more
wiley   +1 more source

Blood flow restriction endurance exercise and endurance performance in athletes

Exercise and Quality of Life
The development and advancement of sports training over time have been accompanied by continuous innovations, which significantly contribute to improving athletic performance.
Matevž Arčon, Nejc Črnčič
doaj   +1 more source

Preoperative circulating tumor cells integrated with imaging analysis for prognostic evaluation in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach, Gizem Abaci, Tom Huberty, Axel Lechner, Lukas Käsmann, Jens Ricke, Sophia Stöcklein, Martin Canis, Philipp Baumeister, Marianna Alunni‐Fabbroni   +9 more
wiley   +1 more source

Investigation of High-Intensity Interval Training (HIIT) Studies in Tennis and Badminton Players

Sportif Bakış Spor ve Eğitim Bilimleri Dergisi, 2021
The aim of this review was to examine the studies on high-intensity interval training (HIIT) applied in tennis and badminton. Considering the duration of the tennis and badminton match, these sports are seen as an aerobic sports.
Yıldız Yaprak, Fikret Ozturk
doaj   +1 more source

DEVELOPMENT OF SPECIAL ENDURANCE OF AIKIDOISTS AT THE TRAINING STAGE OF AIKIDO TRAINING

Физическая культура. Спорт. Туризм. Двигательная рекреация, 2021
The authors revealed the problem of insufficient intensity of performing basic aikido techniques in Aikido examinations due to the insufficient level of development of special endurance of aikidoists.
Sergey Alekseevich Yarushin, Константин Степанович Дунаев, Maksim Yurevich Raduntsev   +2 more
doaj   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Optimizing Arm Muscle Endurance in Pencak Silat Athletes: Insights from a Literature Review

Tanjungpura Journal of Coaching Research
Background and Study Aim. Pencak Silat is a martial art that demands exceptional physical strength, agility, and endurance. Among these, arm muscle endurance plays an important role in performing effective offensive and defensive maneuvers. Improving arm
Jefrio Demitrimus Nubatonis, Sulistiyono Sulistiyono, Muhamad Husein, Irvan Septianto, Salmon Runesi, Dwi Manna Nazmi Zakiah, Julian Dewantara, Jihan Azrina, Syahrizal Islam, Vince Louisse D. Salacup   +9 more
doaj   +1 more source