Results 81 to 90 of about 447,247 (352)

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Exploring the effect of kraft lignin on the stability and decomposition kinetics of nitrated cellulose carbamate

FirePhysChem
This study systematically investigated the stability and thermo-kinetic properties of a high-energy-density nitrated cellulose carbamate (NCC) system stabilized with Kraft lignin.
Lokmene Boumaza, Ahmed Fouzi Tarchoun, Amir Abdelaziz, Yacine Yahi, Nabil Slimani, Chemseddine Boustila, Mohammed Jouini, Thomas M. Klapötke, Weiqiang Pang, Djalal Trache   +9 more
doaj   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Rare Helium-Bearing Compound FeO2He Stabilized at Deep-Earth Conditions

, 2018
There is compelling geochemical evidence for primordial helium trapped in Earth’s lower mantle, but the origin and nature of the helium source remain elusive due to scarce knowledge on viable helium-bearing compounds that are extremely rare.
Chen, Changfeng, Feng, Xiaolei, Li, Hefei, Liu, Hanyu, Lu, Cheng, Lv, Jian, Ma, Yanming, Redferm, Simon A. T., Zhang, Jurong   +8 more
core   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Effect of Nano-Sized Energetic Materials (nEMs) on the Performance of Solid Propellants: A Review [PDF]

, 2021
Weiqiang Pang, Chongqing Deng, Huan Li, Luigi T. DeLuca, Dihua Ouyang, Huixiang Xu, Xuezhong Fan   +6 more
openalex   +1 more source

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

Molecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff, Manuela Moritz, Dennis Eggert, Anna Worthmann, Joerg Heeren, Henrike Zech, Till S. Clauditz, Waldemar Wilczak, Hartmut Schlüter, Christian S. Betz, Arne Böttcher, Jan Hahn   +11 more
wiley   +1 more source

Enhancing accuracy in equivalent in-service-time assessment for homogeneous solid propellants: A novel temperature-independent predictive model utilizing PCA of FTIR data

FirePhysChem
The present study was devoted to setting a universal T-independent predictive model of equivalent in-service-time (EIST) for homogenous solid propellant (HSP) to surpass the limits of the van't Hoff law particularly when high aging temperatures and/or ...
Salim Chelouche, Djalal Trache, Amir Abdelaziz, Ahmed Fouzi Tarchoun, Slimane Bekhouche, WeiQiang Pang   +5 more
doaj   +1 more source

Polynigrogen Energetic Materials

Journal of the Korea Institute of Military Science and Technology, 2016
ABSTRACT Current research trends of prediction of possible structures, synthesis and explosive characteristics of polynitrogen molecules(PNs) are reviewed. Theoretically PNs are composed only of nitrogen atoms, in which N-N bonds are either single or double bonds, and thus when these molecules decompose, release of enormous energy is accompanied.
openaire   +1 more source

Construction of Zwitterionic 3d Hydrogen-Bonded Networks: Exploring the Upper-Limit of Thermal Stability in Ternary Chn-Based Energetic Materials

, 2023
Zhe Wang, Qi Lai, Ning Ding, Ping Yin, Siping Pang, Jean’ne M. Shreeve   +5 more
openalex   +1 more source