Results 91 to 100 of about 447,247 (352)

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Study on erosion prediction model of high-energy gun propellant based on machine learning

FirePhysChem
The erosion characteristics is an important reference index that affects the popularization and application of RDX-based high-energy gun propellant containing energetic plasticizer Diazidonitrazapentane (DIANP).
Maobo Yuan, Rui Wu, Jianwei Jin, Jihua Liu, Changhui He, Hongli Zhao   +5 more
doaj   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Investigation of Flame Structures of Double-Base Propellant and Modified Double-Base Propellant Containing Nitramine Using OH-PLIF and Kinetic Simulation

Molecules
The combustion behavior of various propellant samples, including double-base propellants, pressed nitramine powders, and modified double-base propellants containing nitramine, was examined using OH-PLIF technology.
Yiping Wang, Yan Zhang, Heng Li, Ergang Yao, Jin Yu, Fengqi Zhao, Siyu Xu   +6 more
doaj   +1 more source

Surge current and electron swarm tunnel tests of thermal blanket and ground strap materials [PDF]

, 1977
The results are described of a series of current conduction tests with a thermal control blanket to which grounding straps have been attached. The material and the ground strap attachment procedure are described. The current conduction tests consisted of
Hoffmaster, D. K., Inouye, G. T., Sellen, J. M., Jr.   +2 more
core   +1 more source

Vibrational Signatures in the THz Spectrum of 1,3-DNB: A First-Principles and Experimental Study

, 2016
Understanding the fundamental processes of light-matter interaction is important for detection of explosives and other energetic materials, which are active in the infrared and terahertz (THz) region.
Ahmed, Towfiq, Azad, Abul K., Chellappa, Raja, Dattelbaum, Dana M., Graf, Matthias J., Higginbotham-Duque, Amanda, Moore, David, Zhu, Jian-Xin   +7 more
core   +1 more source

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

Molecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns, Jaclyn S. Long, Sergio Lilla, Kelly Hodge, Marcus J. G. W. Ladds, Colin Nixon, Paula Fernández‐Palanca, Sara Zanivan, Pilar Acedo, Stephen P. Pereira, Kevin M. Ryan   +10 more
wiley   +1 more source

Synthesis and characterization of a 1,3-dibutylimidazolium azide ([BBIm][N3]) : A promising green energetic ionic liquid

Defence Technology
In the pursuit of advancing imidazolium-based energetic ionic liquids (EILs), the current study is devoted to the synthesis and characterization of 1,3-dibutyl-imidazolium azide ([BBIm][N3]), as a novel member in this ionic liquids class.
Nawel Matmat, Amir Abdelaziz, Djalal Trache, Sabrina Achour, Ahmed Fouzi Tarchoun, Hani Boukeciat, Sourbh Thakur, Weiqiang Pang, Thomas M. Klapötke   +8 more
doaj   +1 more source

The effects of the interaction of polymeric materials with the space environment [PDF]

Polymeric materials in low earth orbit will be exposed to a harmful environment mainly due to atomic oxygen and ultraviolet radiation. In geosynchronous earth orbit, the major hazards to such materials are energetic charged particles and ultraviolet ...
Kiefer, Richard L., Orwoll, Robert A.
core   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source