Results 41 to 50 of about 53,726 (221)
Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway
Molecular Oncology, EarlyView.Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed +10 more
wiley +1 more source
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
Efficient Basis Formulation for (1+1)-Dimensional SU(2) Lattice Gauge Theory: Spectral calculations with matrix product states [PDF]
, 2017 We propose an explicit formulation of the physical subspace for a (1+1)-dimensional SU(2) lattice gauge theory, where the gauge degrees of freedom are integrated out.
Bañuls, Mari Carmen +4 more
core +5 more sources
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source
Fast-Decodable Asymmetric Space-Time Codes from Division Algebras
, 2010 Multiple-input double-output (MIDO) codes are important in the near-future wireless communications, where the portable end-user device is physically small and will typically contain at most two receive antennas.
Hollanti, Camilla +2 more
core +1 more source
Experimental Challenges for Quantum Gravity [PDF]
, 2003 The existence of a new fundamental scale may lead to modified dispersion relations for particles at high energies. Such modifications seem to be realized with the Planck scale in certain descriptions of quantum gravity. We apply effective field theory to
Myers, Robert C., Pospelov, Maxim
core +2 more sources
Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source
Ultra-sensitive immunosensing of snake venom by functionalized Sm-Co doped antimony-tungstate
Applied Microbiology and BiotechnologySnake venom has long-term physiological effects on survivor’s life. An electrochemical immunosensor based on samarium-cobalt-doped antimony tungstate (Sb2WO4@Sm-Co) is developed via a solvothermal method to detect snake venom antigens (SVA).
Rimsha Batool +6 more
doaj +1 more source