Results 41 to 50 of about 54,371 (220)

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source

On the Algebraic Theory of Soliton and Antisoliton Sectors [PDF]

, 1995
We consider the properties of massive one particle states on a translation covariant Haag-Kastler net in Minkowski space. In two dimensional theories, these states can be interpreted as soliton states and we are interested in the existence of ...
Schlingemann, Dirk
core   +2 more sources

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Topological Defect Lines and Renormalization Group Flows in Two Dimensions [PDF]

, 2019
We consider topological defect lines (TDLs) in two-dimensional conformal field theories. Generalizing and encompassing both global symmetries and Verlinde lines, TDLs together with their attached defect operators provide models of fusion categories ...
Chang, Chi-Ming, Lin, Ying-Hsuan, Shao, Shu-Heng, Wang, Yifan, Yin, Xi   +4 more
core   +3 more sources

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Nonlinear interaction between electromagnetic fields at high temperature [PDF]

, 1994
The electron-positron `box' diagram produces an effective action which is fourth order in the electromagnetic field. We examine the behaviour of this effective action at high-temperature (in analytically continued imaginary-time thermal perturbation ...
C. Adam, E. Braaten, F. T. Brandt, G. Barton, J. C. Taylor, J. C. Taylor, J. Frenkel, J. Frenkel, J. Frenkel, M. Loewe, R. Baier, R. Karplus, R. Karplus, R. Tarrach, T. S. Evans, W. Dittrich   +15 more
core   +2 more sources

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Polyhedral Cosmic Strings

, 1992
Quantum field theory is discussed in M\"obius corner kaleidoscopes using the method of images. The vacuum average of the stress-energy tensor of a free field is derived and is shown to be a simple sum of straight cosmic string expressions, the strings ...
A. Cayley, A. F. Mobius, A. F. Mobius, A. Hurwitz, A. R. Forsyth, A. Sommerfeld, B. Meyer, C. Caratheodory, D. D. Sokolov, D. Deutsch, D. Harari, E. C. G. Poole, E. M. Serebryanyi, E. Stiefel, F. D. Mazzitelli, F. Klein, F. Klein, F. Pockels, G. Darboux, H. A. Schwarz, H. Huber, H. S. M. Coxeter, H. S. M. Coxeter, J. B. Keller, J. Hodgkinson, J. S. Dowker, J. S. Dowker, L. R. Ford, M. Barriola, O. Laporte, Peter Chang, R. Banach, R. Terras, S. L. Altmann, S. L. Altmann, T. Damhus   +35 more
core   +1 more source

Electrochromic properties of a poly(dithienylfuran) derivative featuring a redox-active dithiin unit [PDF]

, 2012
A teraryl monomer containing a 1,4-dithiin-furan central unit has been synthesised and characterised by single crystal X-ray crystallography. The di(thienyl)furan monomer 11 was successfully polymerised electrochemically and shown to possess a lower ...
Berridge, Rory, Coles, Simon J., Elmasly, Saadeldin E. T., Findlay, Neil J., Kanibolotsky, Alexander L., Kaur, Sandeep, Skabara, Peter, Wilson, Claire   +7 more
core   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source