Results 241 to 250 of about 981,494 (350)

Zinc Exposure Causes Disulfidptosis to Induce Miscarriage by Up‐Regulating GATA1/METTL1/SLC7A11 Axis

Advanced Science, EarlyView.
Zn exposure up‐regulates GATA1, promoting GATA1‐mediated METTL1 and SLC7A11 transcription. It also enhances METTL1‐mediated m7G modification on SLC7A11 mRNA, increasing SLC7A11 mRNA stability. Ultimately, Zn exposure up‐regulates SLC7A11 at both transcriptional and post‐transcriptional levels, causing disulfidptosis. Knockdown of murine Slc7a11, Gata1,
Wenxin Huang, Yi Sun, Yanxin Wang, Haijun Yan, Xiaoping Yue, Weidong Wu, Xueyu Chen, Jinfang Zhang, Yanbing Lin, Qiong Lei, Nan Ji, Shuaishuai Xing, Liqin Zeng, Qingzheng Kang, Depeng Zhao, Geng Guo, Huidong Zhang   +16 more
wiley   +1 more source

State-dependent central synaptic regulation by GLP-1 is essential for energy homeostasis. [PDF]

Nat Metab
Wang L, Savani RH, Lu Y, Bernabucci M, Luis-Islas J, Park E, Singh I, Xu W, El Ouaamari A, Wheeler MB, Grill HJ, Rossi MA, Pang ZP.   +12 more
europepmc   +1 more source

Hypothalamic regulation of energy homeostasis: Quo vadis

M Laínez López, Jeffrey M. Friedman
openalex   +1 more source

Gut Mycobiota‐Associated Tryptophan Catabolites Protect Against Metabolic Dysfunction‐Associated Steatotic Liver Disease

Advanced Science, EarlyView.
ABSTRACT Accumulating evidence suggests that the intestinal microbiota participates in the progression of metabolic dysfunction‐associated steatotic liver disease (MASLD) through microbiota‐host interaction. However, the beneficial role of commensal mycobiota in MASLD progression remains poorly understood.
Shuping Qiao, Shuangya Fan, Juan Xu, Zhen Xu, Chen Peng, Junxing Qu, Ziqian Bing, Shizhen Zhou, Sunan Shen, Guifang Xu, Yue Zhao, Tingting Wang   +11 more
wiley   +1 more source

The Critical Role of the Bile Acid Receptor TGR5 in Energy Homeostasis: Insights into Physiology and Therapeutic Potential. [PDF]

Int J Mol Sci
Zangerolamo L, Carvalho M, Barbosa HCL.
europepmc   +1 more source

Changes in the neuroendocrine control of energy homeostasis by adiposity signals during aging

, 2008
J.M. Carrascosa, Manuel Ros, Antonio Andrés, Teresa Fernández‐Agulló, Carmen Arribas   +4 more
openalex   +2 more sources

Targeting Lactate and Lactylation in Cancer Metabolism and Immunotherapy

Advanced Science, EarlyView.
Lactate, once deemed a metabolic waste, emerges as a central regulator of cancer progression. This review elucidates how lactate and its epigenetic derivative, protein lactylation, orchestrate tumor metabolism, immune suppression, and therapeutic resistance.
Jiajing Gong, Yuhang Xie, Zhijie Weng, Yongzhi Wu, Longjiang Li, Bo Li   +5 more
wiley   +1 more source

Orthopedia regulates melanocortin 4 receptor transcription and energy homeostasis. [PDF]

Sci Transl Med
Xu B, Lawler K, Wyler SC, Li L, Swati, Keogh JM, Chen X, Wan R, Almeida AG, Kirsch S, Mountjoy KG, Elmquist JK, Farooqi IS, Liu C.   +13 more
europepmc   +1 more source

Energy Homeostasis by the Peripheral Serotonergic System

, 2017
Hitoshi Watanabe, Michael T. Rose, Yoshinori Kanayama, Hitoshi Shirakawa, Hisashi Aso   +4 more
openalex   +2 more sources

Time‐Controlled Refrigerated Stem Cell Therapy Mitigates Scleroderma Fibrosis via Modulation of Mitochondrial Autophagy and Gut Metabolism

Advanced Science, EarlyView.
This study established an RT‐MSCs‐based therapeutic approach for scleroderma in mice. RT‐MSCs attenuated fibrosis by regulating mitochondrial autophagy and restored gut microbiota homeostasis. Metabolomic analyses confirmed recovery of key metabolites, and RT‐MSCs demonstrated favorable lesion targeting and safety profiles.
Xue Xia, Chenfei Kong, Xiaoming Zhao, Naixu Shi, Jinlan Jiang, Ping Li   +5 more
wiley   +1 more source