Results 251 to 260 of about 981,494 (350)

Fatty Acid Synthase regulates glucose and energy homeostasis via POMC neurons and adrenergic signals. [PDF]

Mol Metab
Leon-Mercado L, Dong Y, Chen B, Tinajero A, Lord CC, Lee S, Liu C, Liang G, Horton JD, Williams KW, Elmquist JK.   +10 more
europepmc   +1 more source

Decoding Triphenotypic Neutrophils in Cervical Cancer Evolution and Targeting SPP1+/GBP1+/ELOVL5+ Tumor‐Associated Neutrophils to Sensitize Immunotherapy

Advanced Science, EarlyView.
The functional schematic diagram of tumor associated neutrophils. Abstract Enhancing cervical cancer (CC) immunotherapy requires deciphering the heterogeneous tumor immune microenvironment (TIME), particularly neutrophil phenotypic dynamics. Here, 1) we collected 543 CC cases to find that patients with elevated neutrophil levels have a higher incidence
Xingyu Chang, Xinyu Qu, Tingting Ren, Tong Wu, Weiyong Gu, Jingxin Ding, Keqin Hua, Junjun Qiu   +7 more
wiley   +1 more source

Adenosine transmission from hypothalamic tanycytes to AGRP/NPY neurons regulates energy homeostasis. [PDF]

Exp Mol Med
Kim N, Kim S, Park S, Kim EK.
europepmc   +1 more source

Rapid Remodeling of the Human Gut Microbiome in Response to Short‐Term Animal Product Restriction and Associations with Host Molecular Phenotypes

Advanced Science, EarlyView.
A real‐world model of structured animal product restriction practiced for religious reasons reveals the dynamic adaptability of the human gut microbiome to dietary change and uncovers reductions in diversity and rare taxa loss. Integrated microbiome, metabolomic, and proteomic analyses uncover coordinated taxonomic and molecular shifts and identify ...
Christina Emmanouil, Maria Anezaki, Alexandros Simistiras, Stavros Glentis, Nikolaos Scarmeas, Pantelis Hatzis, Konstantinos Rouskas, Antigone S. Dimas   +7 more
wiley   +1 more source

Author Correction: Hypothalamic S1P/S1PR1 axis controls energy homeostasis. [PDF]

Nat Commun
Silva VRR, Micheletti TO, Pimentel GD, Katashima CK, Lenhare L, Morari J, Mendes MCS, Razolli DS, Rocha GZ, de Souza CT, Ryu D, Prada PO, Velloso LA, Carvalheira JBC, Pauli JR, Cintra DE, Ropelle ER.   +16 more
europepmc   +1 more source

De Novo Multi‐Mechanism Antimicrobial Peptide Design via Multimodal Deep Learning

Advanced Science, EarlyView.
Current AI‐driven peptide discovery often overlooks complex structural data. This study presents M3‐CAD, a generative pipeline that leverages 3D voxel coloring and a massive database of over 12 000 peptides to capture nuanced physicochemical contexts.
Xiaojuan Li, Haifan Gong, Yue Wang, Yinuo Zhao, Lixiang Li, Peijing Bao, Qingzhou Kong, Jialu Fu, Boyao Wan, Yumeng Zhang, Jinghui Zhang, Jiekun Ni, Zhongxue Han, Xueping Nan, Kunping Ju, Longfei Sun, Yuerui Ma, Huijun Chang, Mengqi Zheng, Yanbo Yu, Xiaoyun Yang, Xiuli Zuo, Haina Wang, Yanqing Li   +23 more
wiley   +1 more source

The ARC^CRABP1 neurons play a crucial role in the regulation of energy homeostasis. [PDF]

Nat Commun
Yan L, Zhang X, Jin L, Li Y, Chen Y, Zhang J, Sun Z, Qi J, Qu C, Dong G, Zhang Y, Jiang Q, Liu A, Li J.   +13 more
europepmc   +1 more source

Hepatocyte PIEZO1 Negatively Regulates Lipogenesis and Ameliorates MASLD by Sensing Membrane Tension and Activating AMPK

Advanced Science, EarlyView.
Hepatocytes are subjected to increased membrane tension along with lipid accumulation. Loss of PIEZO1 exacerbates high‐fat diet‐induced MASLD in mice. Activation of PIEZO1 alleviates high‐fat diet‐induced MASLD in mice. PIEZO1 negatively regulates de novo lipogenesis through activation of CaMKK2‐AMPK pathway. ABSTRACT Liver is a central organ for lipid
Hui Chen, Qimeng Wang, Ke Yang, Qinghai Lian, Xuyun Peng, Zhiyong Gong, Xinyi Zhao, Yong Wu, Tian Tao, Siqi Xu, Yifan Chen, Xiaoyan Tang, Jinghui Guo, Geyang Xu, Qi Zhang   +14 more
wiley   +1 more source

Lipopolysaccharide affects metabolic processes and energy homeostasis in the corpus luteum. [PDF]

Front Mol Biosci
Mierzejewski K, Stryiński R, Bogacka I, Golubska M, Carrera M, Kurzynska A.   +5 more
europepmc   +1 more source

Insulin resistance and whole body energy homeostasis in obese adolescents with fatty liver disease

, 2006
Gianluca Perseghin, Riccardo Bonfanti, Serena Magni, Guido Lattuada, Francesco De Cobelli, Tamara Canu, Antonio Esposito, Paola Scifo, Georgia Ntali, Federica Costantino, Laura Bosio, Francesca Ragogna, Alessandro Del Maschio, G Chiumello, Livio Luzi   +14 more
openalex   +2 more sources