Results 91 to 100 of about 8,045,022 (405)

Dietary fat and total energy intake modifies the association of genetic profile risk score on obesity: evidence from 48 170 UK Biobank participants [PDF]

, 2017
Background: Obesity is a multifactorial condition influenced by both genetics and lifestyle. The aim of this study was to investigate whether the association between a validated genetic profile risk score for obesity (GPRS-obesity) and body mass index ...
Anderson, Jana, Bailey, Mark E.S., Celis-Morales, Carlos, Gill, Jason M.R., Gray, Stuart, Guo, Yibing, Iliodromiti, Stamatina, Lyall, Donald M., Mackay, Daniel F., Pell, Jill, Petermann, Fanny, Sattar, Naveed, Steell, Lewis, Welsh, Paul   +13 more
core   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Energy Intake, Profile, and Dietary Sources in the Spanish Population: Findings of the ANIBES Study

Nutrients, 2015
Energy intake, and the foods and beverages contributing to that, are considered key to understanding the high obesity prevalence worldwide. The relative contributions of energy intake and expenditure to the obesity epidemic, however, remain poorly ...
Emma Ruiz, J. M. Ávila, T. Valero, Susana del Pozo, Paula Rodríguez, Javier Aranceta-Bartrina, Á. Gil, M. González-Gross, R. Ortega, L. Serra-Majem, G. Varela-Moreiras   +10 more
semanticscholar   +1 more source

Appetite, energy intake and resting metabolic responses to 60 min treadmill running performed in a fasted versus a postprandial state. [PDF]

, 2012
This study investigated the effect of fasted and postprandial exercise on appetite, energy intake and resting metabolic responses. Twelve healthy males (mean±SD: age 23±3 years, body mass index 22.9±2.1 kg m(-2), maximum oxygen uptake 57.5±9.7 mL kg(-1 ...
Deighton, K, Stensel, DJ, Zahra, JC
core   +1 more source

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

Molecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia, Noelia Moares, Wenjie Yi‐He, Rosa Luna‐Espejo, Ricardo Fernandez‐Cisnal, Javier Ocaña‐Cuesta, Juan P. Muñoz‐Miranda, Antonio Gabucio, Cecilia M. Fernandez‐Ponce, Francisco Garcia‐Cozar   +9 more
wiley   +1 more source

BODY IMAGE MAHASISWA GIZI SERTA KAITANNYA DENGAN ASUPAN ENERGI DAN STATUS GIZI
Body Image of Nutrition College Students and its Association with Energy Intake and Nutritional Status

Media Gizi Indonesia, 2020
Nutrition college students as a representatives in society is required to have ideal and healthy body. Besides aff ected by those demands, body image is also aff ected by nutritional status and energy intake.
Alifatuz Zahrah, Lailatul Muniroh
doaj   +1 more source

An evaluation of enteral nutrition practices and nutritional provision in children during the entire length of stay in critical care [PDF]

, 2014
<b>Background</b> Provision of optimal nutrition in children in critical care is often challenging. This study evaluated exclusive enteral nutrition (EN) provision practices and explored predictors of energy intake and delay of EN ...
A Slater, AF Rousseau, C Lambe, David Young, DO Health, EJ Rogers, Emma Gentles, GC Briassoulis, GS Doig, GS Doig, H Woien, Hani A Alfheeaid, IM Mitchell, J Hulst, Jackie Mara, JL Vazquez Martinez, JM Hulst, JM Hulst, Konstantinos Gerasimidis, Krystalia Diamantidi, LF Lima, MA Holliday, Mark Davidson, MM Pollack, Neil Spenceley, NM de, R Meyer, RM Taylor, SB de Oliveira Iglesias, T Petrillo-Albarano, TA Mikhailov, TJ Cole, WN Schofield   +32 more
core   +3 more sources

Eating Pattern Response to a Low-Fat Diet Intervention and Cardiovascular Outcomes in Normotensive Women: The Women's Health Initiative. [PDF]

, 2020
BackgroundWomen without cardiovascular disease (CVD) or hypertension at baseline assigned to intervention in the Women's Health Initiative Dietary Modification (DM) trial experienced 30% lower risk of coronary heart disease (CHD), whereas results in ...
Allison, Matthew A, Aragaki, Aaron K, Howard, Barbara V, Isasi, Carmen R, Manson, JoAnn E, Mossavar-Rahmani, Yasmin, Neuhouser, Marian L, Prentice, Ross L, Thomson, Cynthia A, Van Horn, Linda, Vitolin, Mara Z, Wallace, Robert B, WHI Investigators   +12 more
core   +1 more source

An energy sensor for control of energy intake [PDF]

Proceedings of the Nutrition Society, 1997
Control of energy intake, either in response to changes in the energy content of food or in energy expenditures and storage, is based on the detection of a feedback signal generated in the processing of metabolic fuels for energy. Evidence from studies of the fructose analogue, 2,5-AM, indicates a sensor in liver responds to changes in intracellular ...
openaire   +2 more sources

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source