Results 71 to 80 of about 892,612 (361)

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Energy and Protein Intake and Its Relationship with Pulmonary Function in Chronic Obstructive Pulmonary Disease (COPD) Patients [PDF]

Acta Medica Iranica, 2010
Chronic Obstructive Pulmonary Disease (COPD) is a public health problem worldwide. Increased energy and protein needs, decreased energy and protein intake are common in COPD patients.
Leila Yazdanpanah, Farzad Shidfar, Ali Javad Moosavi, Hassan Heidarnazhad, Hamid Haghani   +4 more
doaj   +1 more source

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

Molecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia, Noelia Moares, Wenjie Yi‐He, Rosa Luna‐Espejo, Ricardo Fernandez‐Cisnal, Javier Ocaña‐Cuesta, Juan P. Muñoz‐Miranda, Antonio Gabucio, Cecilia M. Fernandez‐Ponce, Francisco Garcia‐Cozar   +9 more
wiley   +1 more source

Appetite, energy intake and resting metabolic responses to 60 min treadmill running performed in a fasted versus a postprandial state. [PDF]

, 2012
This study investigated the effect of fasted and postprandial exercise on appetite, energy intake and resting metabolic responses. Twelve healthy males (mean±SD: age 23±3 years, body mass index 22.9±2.1 kg m(-2), maximum oxygen uptake 57.5±9.7 mL kg(-1 ...
Deighton, K, Stensel, DJ, Zahra, JC
core   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Sex differences in the association between total energy intake and all-cause mortality among patients with metabolic dysfunction-associated steatotic liver disease

Scientific Reports
The long-term association between total energy intake and clinical outcomes in patients with metabolic dysfunction-associated steatotic liver disease (MASLD) remains unclear. The present study aimed to explore the associations between total energy intake
Changsi Wang, Hongfei Ma, Hongfang Yang, Qi Nie, Lin Zhu, Jiawei Yin, Li Zhou   +6 more
doaj   +1 more source

Pengaruh asupan energi dan protein terhadap perubahan status gizi pasien anak selama dirawat di RSUP Dr. Kariadi Semarang

Jurnal Gizi Indonesia: The Indonesian Journal of Nutrition, 2016
Background : Adequate energy and  protein  intake  for  children  patients is required as efforts to prevent decline in nutritional status during hospitalization.
Bandawati Bandawati, Maria Mexitalia, M. Zen Rahfiludin   +2 more
doaj   +1 more source

BODY IMAGE MAHASISWA GIZI SERTA KAITANNYA DENGAN ASUPAN ENERGI DAN STATUS GIZI
Body Image of Nutrition College Students and its Association with Energy Intake and Nutritional Status

Media Gizi Indonesia, 2020
Nutrition college students as a representatives in society is required to have ideal and healthy body. Besides aff ected by those demands, body image is also aff ected by nutritional status and energy intake.
Alifatuz Zahrah, Lailatul Muniroh
doaj   +1 more source

Associations between diet, physical activity and body fat distribution: a cross sectional study in an Indian population. [PDF]

, 2015
BACKGROUND: Obesity is a growing health problem in India and worldwide, due to changes in lifestyle. This study aimed to explore the independent associations between dietary and physical activity exposure variables and total body fat and distribution in ...
Ben-Shlomo, Yoav, Bowen, Liza, Ebrahim, Shah, Ekelund, Ulf, Kinra, Sanjay, Krishna, KV Radha, Kulkarni, Bharati, Kuper, Hannah, Sullivan, Ruth, Taylor, Amy E, Wells, Jonathan CK   +10 more
core   +4 more sources

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source