Results 221 to 230 of about 1,446,253 (304)
Infusible Extracellular Matrix Biomaterial Enhances Cell‐Specific Pro‐Repair Responses Following Acute Myocardial Infarction
Advanced Healthcare Materials, EarlyView.We measure the cell‐specific responses of administering infusible ECM (iECM) in acute myocardial infarction (MI) across multiple timepoints. Using single‐nucleus RNA sequencing and spatial transcriptomics, we measure macrophage activation, fibroblast remodeling, increased vascular development, lymphangiogenesis, cardioprotection, and neurogenesis ...Joshua M. Mesfin, Alexander Chen, Quincy P. Lyons, Michael B. Nguyen, Maria L. Karkanitsa, Justin Yu, Van K. Ninh, Emily Gardner, Elyse G. Wong, Sriya N. Paleti, Julian Cheng, Benjamin D. Bridgelal, Kate E. Reimold, Selena Cao, Connor Uhre, Colin G. Luo, Zhenxing Fu, Kevin R. King, Karen L. Christman +18 morewiley +1 more sourceParaventricular nucleus-locus coeruleus VGlut2 neural circuit regulates energy metabolism in mice. [PDF]
Cell Death DisLiu H, Li P, Yu M, Zhang X, Zhu H, He Y, Zhang Z, Li X, Teng B, Fan J, Yang W, Yin J, Hao Q, Cao G, Li H, Liu S, Li Y, Ren J, Chen Y, Du C. +19 moreeuropepmc +1 more sourceThe Floor‐Ceiling‐Chip, or 2 × 2D = Pseudo‐3D—Approaching 3D Cell Morphology and Organization between Two Opposing 2D Substrates with Cell‐Adhesive Protein Micropatterns
Advanced Healthcare Materials, EarlyView.Here, we present a novel 3D cell patterning and culture platform. The “Floor‐Ceiling‐Chip” (FC‐Chip) consists of two opposing track‐etched membranes, creating a pseudo‐3D microenvironment for the cells in between. By providing the membranes with micropatterned cell‐adhesive islands of varying geometries and sizes, the FC‐Chip enables control over cell ...Urandelger Tuvshindorj, Francesca Giacomini, Esra Güben Kaçmaz, Tim ten Brink, Lorenzo Moroni, Zeinab Tahmasebi Birgani, Clemens van Blitterswijk, Pamela Habibović, Stefan Giselbrecht, Jan de Boer, Roman Truckenmüller +10 morewiley +1 more sourceBiomimetic Copper‐Doped Nano‐Aluminum Adjuvant Potentiates Therapy in Chemoresistant Acute Myeloid Leukemia
Advanced Healthcare Materials, EarlyView.We developed a novel copper‐doped aluminum nano‐adjuvant (CuNA) to overcome cytarabine resistance in acute myeloid leukemia (AML). CuNA effectively sensitizes drug‐resistant AML cells to cytarabine by inducing mitochondrial dysfunction and inhibiting HMGCR/GPX4 to amplify ferroptosis.Chao He, Lingxiao Zhang, Yue Xiong, Yu Wang, Yuqing Zeng, Dandan Su, Ran Wang, Ying Li, Hongbo Chen, Fang Cheng, Zhi Ping Xu +10 morewiley +1 more sourceEnergy metabolism
, 2010 Bart Ellenbroek, Alfonso Abizaid, Shimon Amir, Martina de Zwaan, Sarah Parylak, Pietro Cottone, Eric P. Zorrilla, Lawrence H. Price, Ben J. Harrison, Christos Pantelis, Lawrence H. Price, Sophie Tambour, John C. Crabbe, Ian P. Stolerman, Nicola Simola, Micaela Morelli, Michael H. Bloch, Sarah Morgan, Angus Mackay, Gary Remington, Sidney H. Kennedy, Sakina J. Rizvi, Giovanni Hernandez, Peter Shizgal, Mitul A. Mehta, Ennio Esposito, Roberto William Invernizzi, Darren R. Christensen, Warren K. Bickel, Lynette C. Daws, Anne M. Andrews, Greg A. Gerhardt, Lawrence H. Price, Mischa de Rover, Sander Nieuwenhuis, Peter H. Boeijinga, Victoria L. Harvey, Anthony H. Dickenson, Peter Verheart, Per Svenningsson, Per E. Andrén, Antonio Pádua Carobrez, Grasielle C. Kincheski, Leandro J. Bertoglio, Kim Wolff, Iván Izquierdo, Lia Rejane M. Bevilaqua, Martin Cammarota, David H. Zald, Oliver Stiedl, Sven Ove Ögren, Joseph Zohar, Alan J. Budney, Oliver Stiedl, Sven Ove Ögren, Cecilia J. Hillard, Alfonso Abizaid, Shimon Amir, Josee E. Leysen, Samuel B. Hutton, Michael M. Morgan, MacDonald J. Christie, Paul Willner, Michael M. Morgan, MacDonald J. Christie, Martina de Zwaan, Jason C. G. Halford, Peter Riederer, Siegfried Hoyer, Francis C. Colpaert, Michael M. Morgan, MacDonald J. Christie, Michael M. Morgan, MacDonald J. Christie, Daniel Hoyer, Paul D. Callaghan, Iain S. McGregor, Murray R. Thompson, Kim Wolff, Mary E. Cain, Michael T. Bardo, Christoph Hiemke, Christoph Hiemke, Lawrence S. Wilkinson, Anthony R. Isles, Celia J. A. Morgan, Valerie H. Curran, Victoria L. Harvey, Anthony H. Dickenson, Mark Slifstein, Jos Prickaerts, David E. Nichols, Lawrence H. Price, Marc N. Branch, Mohammed Shoaib, Jill B. Becker, Marilyn E. Carroll, Peter A. Santi, Marilyn E. Carroll, Peter A. Santi, Juan J. López-Ibor, Maria-Inés López-Ibor, Maria-Inés López-Ibor, Juan J. López-Ibor, Berend Olivier, Naheed (Max) Mirza, Seiya Miyamoto, Mohammed Shoaib, Bernard Le Foll, Cyril Höschl, Sander Nieuwenhuis, Mischa de Rover, Mischa de Rover, Sander Nieuwenhuis, David S. Baldwin, Cyril Höschl, Thomas Steckler, Michel Billiard, Linda Lundström, Will Spooren, Silvia Gatti McArthur, Linda Lundström, Silvia Gatti McArthur, Will Spooren, Darrel J. Pemberton, Kim Wolff, Andrea Bari, Josee E. Leysen, Samuel B. Hutton, Amee B. Patel, Kim Fromme, Kim Fromme, Amee B. Patel, Kim Fromme, Amee B. Patel, Kim Fromme, Amee B. Patel, Suzanne H. Mitchell, Harriet de Wit, Matthew I. Palmatier, Rick A. Bevins, Victoria L. Harvey, Anthony H. Dickenson, David S. Tait, Verity J. Brown, W. Wolfgang Fleischhacker, Samuel B. Hutton +146 moreopenaire +3 more sourcesDual‐Peptide Nanoplatform: Mesoporous Silica Nanoparticles Functionalized With a Cell‐Penetrating Peptide and Loaded With Rationally Designed Antimicrobial Peptides for Tuberculosis Therapy
Advanced Healthcare Materials, EarlyView.Machine learning–guided engineering of a plectasin‐derived peptide yields DC05, a potent antimycobacterial candidate. Encapsulation into tuftsin‐functionalized mesoporous silica nanoparticles enhances intracellular delivery, stability, and activity against Mycobacterium tuberculosis while maintaining low cytotoxicity and minimal hemolysis. The combined Christian S. Carnero Canales, Cesar Augusto Roque‐Borda, Ana Carolina Cerqueira Negri, Oswaldo Ramirez Delgado, Letícia Oliveira Catarin Nunes, Flávia Aparecida Resende, Hernane Barud, Norival Alves Santos‐Filho, Saulo Santesso Garrido, Karen Cristina Oliveira, Alexandra Ivo de Medeiros, Rafael Miguel Sábio, Fernando Rogério Pavan +12 morewiley +1 more source
