Results 31 to 40 of about 1,022 (177)

Microglial CLEC7A restrains amyloid beta plaque pathology in a mouse model of Alzheimer's disease

Alzheimer's &Dementia, Volume 21, Issue 11, November 2025.
Abstract INTRODUCTION CLEC7A is a surface receptor that is highly upregulated on microglia in many Alzheimer's disease (AD) models. Little is known about the role that microglial CLEC7A signaling plays in AD‐related pathogenesis. METHODS We utilized an inducible, central nervous system (CNS) macrophage‐specific knockout of Clec7a to evaluate the role ...
Aman Mangalmurti, Kristine E. Zengeler, Ava Hollis, Emily Golden, Gabrielle Riddlemoser, John R. Lukens   +5 more
wiley   +1 more source

Predicting medical prognosis in patients with glioblastoma during inpatient rehabilitation using bed mobility function

PM&R, Volume 17, Issue 11, Page 1343-1353, November 2025.
Abstract Background Determining appropriate suitability and goals for inpatient rehabilitation of patients with glioblastoma, isocitrate dehydrogenase‐wildtype (GBM) requires real‐time prognostic information. Functional measures, such as bed mobility, are standardized scores that can be assessed by members of the care team at the bedside and may aid ...
Tomasz Gruchala, Christopher W. Lewis, Kathryn Abplanalp, Prakash Jayabalan, Theresa L. Walunas, Jodi L. Johnson, Derek A. Wainwright, Rimas V. Lukas, Gayle Spill, Ishan Roy   +9 more
wiley   +1 more source

Six Drivers of Aging Identified Among Genes Differentially Expressed With Age

Aging Cell, Volume 24, Issue 11, November 2025.
A meta‐analysis of 25 transcriptomic datasets from mammalian tissues revealed 45 genes consistently upregulated or downregulated with age. Orthologs of these genes were functionally evaluated using Caenorhabditis elegans lifespan screens to reveal those with causal roles in the aging process, thus identifying six evolutionarily conserved drivers of ...
Ariella Coler‐Reilly, Zachary Pincus, Erica L. Scheller, Roberto Civitelli   +3 more
wiley   +1 more source

Associations Between Pre‐Existing Autoimmunity and Chimeric Antigen Receptor T Cell Therapy Toxicity for Cancer Treatment

ACR Open Rheumatology, Volume 7, Issue 10, October 2025.
Objective Chimeric antigen receptor (CAR) T cell therapy is being investigated to treat individuals with autoimmune diseases. Data regarding the safety of CAR T cell therapy in this population are limited. We aimed to assess whether pre‐existing autoimmune disease was associated with an increase in major toxicity or hospital length of stay (LOS) among ...
Gregory J. Challener, Chen Wang, David Gritsch, Ilana M. Usiskin, Zandra E. Walton, Minna J. Kohler, Hyon Choi, Jeffrey A. Sparks   +7 more
wiley   +1 more source

Caracterización de los pacientes con enfermedad de Parkinson

Acta Médica del Centro, 2021
Introducción: la enfermedad de Parkinson es un proceso degenerativo complejo del sistema nervioso central de inicio insidioso progresivo y desarrollo lento que es consecuencia de una lesión idiopática en el sistema extrapiramidal.
Lázaro Aurelio Vázquez Gómez, Liovesky Madrigal Mora, Ana María Mederos Herrera, Yanet Valdés Morales   +3 more
doaj  

Factors associated with the quality of life of subjects with Parkinson's disease and burden on their caregivers

Neurología (English Edition), 2015
Introduction: Parkinson's disease affects the quality of life of the individual with the disease in addition to creating a burden on the caregiver. Factors related to these effects include motor and non-motor aspects of the disease, as well as traits ...
M. Rodríguez-Violante, A. Camacho-Ordoñez, A. Cervantes-Arriaga, P. González-Latapí, S. Velázquez-Osuna   +4 more
doaj   +1 more source

A Machine‐Learning Approach Identifies Rejuvenating Interventions in the Human Brain

Advanced Science, Volume 12, Issue 37, October 6, 2025.
Rising life expectancy increases the incidence of age‐related neurodegeneration. Reverting brain aging through effective rejuvenation strategies constitutes a promising strategy to counteract these disorders and restore brain function. This study uses a brain‐specific transcriptional aging clock to screen over 43 000 perturbation profiles, identifying ...
Guillem Santamaria, Cristina Iglesias, Sascha Jung, Javier Arcos Hodar, Ruben Nogueiras, Antonio del Sol   +5 more
wiley   +1 more source

Implicaciones de la microbiota intestinal en la etiología y terapéutica de la enfermedad de Parkinson

Revista Habanera de Ciencias Médicas, 2018
Introducción: Es reconocido que pacientes con la Enfermedad de Parkinson suelen manifestar trastornos gastro-intestinales, y que la microbiota intestinal modula la gravedad de la presentación clínica de esta enfermedad.
Luis Enrique Almaguer Mederos, Wilmer Martínez Martínez, David Guach Hevia   +2 more
doaj  

Factores asociados a la calidad de vida de sujetos con enfermedad de Parkinson y a la carga en el cuidador

Neurología, 2015
Resumen: Introducción: La enfermedad de Parkinson impacta en la calidad de vida del sujeto que la presenta, pero también ocasiona una carga para el cuidador.
M. Rodríguez-Violante, A. Camacho-Ordoñez, A. Cervantes-Arriaga, P. González-Latapí, S. Velázquez-Osuna   +4 more
doaj   +1 more source

Cortical thickness subtypes in cognitively unimpaired individuals: Differential network and transcriptomic vulnerability to cortical thinning

Alzheimer's &Dementia, Volume 21, Issue 10, October 2025.
Abstract INTRODUCTION The emergence, stability, and contributing factors of Alzheimer's disease (AD) gray matter subtypes remain unclear. METHODS We analyzed data from 1323 individuals without a diagnosis of dementia (CDR < 1) with T1w‐MRI and amyloid‐PET, including 622 with longitudinal data (3.66 ± 1.78 years).
Luigi Lorenzini, Mario Tranfa, Leonard Pieperhoff, Federico Masserini, Mara ten Kate, Lyduine E. Collij, Giuseppe Pontillo, Emma S. Luckett, Alle Meije Wink, Henk JMM Mutsaerts, Tiago Gil Oliveira, Daniele Altomare, Mercè Boada, Anouk den Braber, Cindy Birck, Christopher Buckley, Gill Farrar, Wiesje van der Flier, Giovanni B. Frisoni, Rossella Gismondi, Juan Domingo Gispert, Bernard J. Hanseeuw, Frank Jessen, Marta Marquié, Anja Mett, Craig Ritchie, Gemma Salvadó, Michael Schöll, Mahnaz Shekari, Andrew W. Stephens, Betty M. Tijms, David Vállez García, Rik Vandenberghe, Pieter Jelle Visser, Luca Roccatagliata, Neil P. Oxtoby, Matteo Pardini, Frederik Barkhof   +37 more
wiley   +1 more source