Results 101 to 110 of about 181,707 (268)

Manejo del paciente con enfermedades mitocondriales [PDF]

open access: yes, 2019
Las enfermedades mitocondriales son un grupo de mutaciones englobadas dentro de las denominadas “enfermedades raras”. Son producidas por alteraciones en el mtDNA, que generan un déficit en la síntesis de ATP; la energía básica para el correcto ...
García Díez, Jorge
core  

Novel insights into the assembly of the yeast translation initiation multifactor complex: The critical role of eIF5

open access: yesProtein Science, Volume 35, Issue 5, May 2026.
Abstract The eukaryotic translation initiation is a biological process in which at least a dozen eukaryotic initiation factors (eIFs) are involved. Specifically, eIF3, eIF1, eIF5, and eIF2 as a ternary complex (eIF2‐TC) bound to GTP and methionyl initiator tRNA (Met‐tRNAiMet).
Borja Sáez de la Fuente   +6 more
wiley   +1 more source

Clonal chromosomal mosaicism and loss of chromosome Y in elderly men increase vulnerability for SARS-CoV-2

open access: yesCommunications Biology
The pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2, COVID-19) had an estimated overall case fatality ratio of 1.38% (pre-vaccination), being 53% higher in males and increasing exponentially with age. Among 9578 individuals
Luis A. Pérez-Jurado   +10 more
doaj   +1 more source

Network perspective of histamine related diseases [PDF]

open access: yes, 2017
Histamine is the most pleiotropic biogenic amine. Produced and stored by a limited set of cells—histaminergic neurons, enterochromaffin-like cells, and mast cells—it broadcasts intercellular communication signals to a wide variety of cell types through ...
Medina, Miguel Ángel   +3 more
core  

Edge Effect on the Distribution of the Green Shield Bug Palomena prasina in Hazelnut Orchards, and the Role of Adjacent Habitats in Crop Colonization

open access: yesEntomologia Experimentalis et Applicata, Volume 174, Issue 5, Page 461-474, May 2026.
Spring–Summer spatial dynamics of Palomena prasina (L.) and potential IPM strategies. ABSTRACT Palomena prasina (L.) (Hemiptera: Pentatomidae), the green shield bug (GSB), is an important hazelnut pest in Southern Europe. Currently, its control focuses on insecticide spraying during the crop season. We hypothesized that, as for other pentatomid species,
Laetitia Driss   +4 more
wiley   +1 more source

Screening of Synergic Interactions of Anti-Angiogenic and Anti-Tumor Compounds [PDF]

open access: yes, 2015
Solid cancers have several common characteristics that Hanahan & Weinberg named as the hallmarks of cancer. Angiogenesis is an essential hallmark of cancer because tumor cells need oxygen and nutrients delivered by the vascular system.
García-Vilas García, Javier Alejandro   +2 more
core  

Caracterización, evaluación y diseño de intervención en una niña afectada por el Síndrome de Midas [PDF]

open access: yes, 2015
Este trabajo presenta los resultados de una investigación sobre un caso de síndrome de Midas, una enfermedad considerada rara. Es un trastorno genético que origina, entre otros trastornos, microftalmia, defectos en la piel, epilepsia persistente y ...
Peirats Chacón, José   +1 more
core   +2 more sources

Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib

open access: yesMolecular Oncology, Volume 20, Issue 4, Page 920-932, April 2026.
WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute   +17 more
wiley   +1 more source

CRISPR for Bio-Art? [PDF]

open access: yes, 2018
Es el resumen de mi ponencia oral (seleccionada entre todas las propuestas recibidas de todo el mundo, siendo una de las 12 únicas comunicaciones orales y la única con representante español en dicho Simposio).This communication will explain the ...
Medina, Miguel Ángel
core  

Trabajar para pacientes con enfermedades raras, de baja prevalencia y complejas: share, care, cure [PDF]

open access: yes, 2017
El ISBN corresponde a la versión electrónica del documentoCada año, se diagnostica una enfermedad rara a medio millón de europeos. Ningún país puede afrontar este reto en solitario.
Comisión Europea. Dirección General de Salud y Seguridad Alimentaria
core   +1 more source

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