Carbon monoxide production from five volatile anesthetics in dry sodalime in a patient model: halothane and sevoflurane do produce carbon monoxide; temperature is a poor predictor of carbon monoxide production [PDF]
BMC Anesthesiology, 2005 Background Desflurane and enflurane have been reported to produce substantial amounts of carbon monoxide (CO) in desiccated sodalime. Isoflurane is said to produce less CO and sevoflurane and halothane should produce no CO at all.
Perez Roberto SGM +2 more
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Effects of maternal enflurane exposure on NR2B expression in the hippocampus of their offspring [PDF]
Brazilian Journal of Pharmaceutical Sciences, 2015 This work aims to study the pathogenesis of learning and memory impairment in offspring rats resulting from maternal enflurane anesthesia by focusing on the expression of the N-methyl-d-aspartic acid receptor subunit 2B (NR2B) in the hippocampus of the ...
Fo-Quan Luo +6 more
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Exposure to halogenated ethers causes neurodegeneration and behavioural changes in young healthy experimental animals: a systematic review and meta analyses [PDF]
Scientific Reports, 2023 The FDA issued a warning that repeated and prolonged use of inhalational anaesthetics in children younger than 3 years may increase the risk of neurological damage. Robust clinical evidence supporting this warning is however lacking.
Carlijn R. Hooijmans +6 more
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PKQuest: volatile solutes – application to enflurane, nitrous oxide, halothane, methoxyflurane and toluene pharmacokinetics [PDF]
BMC Anesthesiology, 2002 Background The application of physiologically based pharmacokinetic models (PBPK) to human studies has been limited by the lack of the detailed organ information that is required for this analysis.
Levitt David G
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Cross-approximate entropy of cortical local field potentials quantifies effects of anesthesia - a pilot study in rats [PDF]
BMC Neuroscience, 2010 Background Anesthetics dose-dependently shift electroencephalographic (EEG) activity towards high-amplitude, slow rhythms, indicative of a synchronization of neuronal activity in thalamocortical networks. Additionally, they uncouple brain areas in higher
Schwarz Cornelius +5 more
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Identification of key potassium channel genes of temporal lobe epilepsy by bioinformatics analyses and experimental verification [PDF]
Frontiers in Neurology, 2023 One of the most prevalent types of epilepsy is temporal lobe epilepsy (TLE), which has unknown etiological factors and drug resistance. The detailed mechanisms underlying potassium channels in human TLE have not yet been elucidated.
Lin-ming Zhang +10 more
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UPTAKE AND ELIMINATION OF ENFLURANE IN MAN
British Journal of Anaesthesia, 1972 SUMMARY The rate of increase of alveolar concentration of enflurane was studied in patients during general anaesthesia with controlled ventilation. Elimination was studied after 30 and 60 min of body equilibration. Halothane and enflurane were administered simultaneously in a second group of patients to compare their uptake curves.
Giangiacomo Torri +3 more
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No Ignition Risk with Hyperbaric Enflurane [PDF]
Anaesthesia and Intensive Care, 1978 A series of experiments was undertaken with Enflurane under hyperbaric conditions to determine whether or not it was explosive under these conditions. No risk of detonation was shown with concentrations of Enflurane up to 5% in either oxygen or nitrous oxide mixtures under conditions of hyperbaria to 3 A.T.A. (Atmospheres Absolute).
A. B. Baker, Ian P. Unsworth
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Anesthesia & Analgesia, 1986 We evaluated 88 cases of hepatic injury that followed, and were attributed to, enflurane anesthesia. In 30 of the cases, data were insufficient to assess the role of enflurane vs other variables as causal factors. In 43 ("unlikely") patients, factors known to produce hepatic injury were clearly present; in the remaining 15 ("possible"), such factors ...
Edmond I. Eger +4 more
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