Results 31 to 40 of about 8,151 (239)

Use of Drugs With Actionable Pharmacogenetic Biomarkers and Possible Prescribing Changes Among Older People

Journal of the American Geriatrics Society, Volume 73, Issue 12, Page 3679-3689, December 2025.
This graphical abstract illustrates the annual prevalence of exposure to CPIC Level A drugs among older adults, categorized by type of pharmacogenetic recommendation. Data are presented per 1000 older individuals (A) and per 1000 prescriptions (B).
Zinan Zhao, Yuxuan Zhao, Xiaowen Hu, Xue Wang, Gengchen Wang, Xinyi Zhang, Wenliang Dong, Luwen Shi, Xiaodong Guan, Christine Y. Lu, Pengfei Jin, Xiaoyan Nie   +11 more
wiley   +1 more source

Mechanisms of Volatile Anesthetic-Induced Myocardial Protection [PDF]

, 2003
Volatile anesthetics protect myocardium against reversible and irreversible ischemic injury. Experimental evidence from several in vitro and in vivo animal models demonstrates that volatile agents enhance the recovery of stunned myocardium and reduce the
Gu, Weidong, Kersten, Judy R., LaDisa, John F., Ludwig, Lynda M., Pagel, Paul S., Tanaka, Katsuya, Warltier, David C.   +6 more
core   +1 more source

Myrtucommulone from Myrtus communis exhibits potent anti-inflammatory effectiveness in vivo. [PDF]

, 2009
Myrtucommulone a nonprenylated acylphloroglucinol contained in the leaves of myrtle (Myrtus communis), has been reported to suppress the biosynthesis of eicosanoids by inhibition of 5-lipoxygenase and cyclooxygenase-1 in vitro and to inhibit the release ...
BRAMANTI P., CAMINITI R., CUZZOCREA S., DI PAOLA R., GENOVESE T., KOEBERLE A., MAZZON E., PERGOLA C., ROSSI, ANTONIETTA, SAUTEBIN, LIDIA, WERZ O.   +10 more
core   +1 more source

Bidirectional Relationship Between Anaesthetic Drugs and Metabolic Syndrome: Clinical Effects and Mechanisms

Journal of Cellular and Molecular Medicine, Volume 29, Issue 20, October 2025.
ABSTRACT Metabolic syndrome (MS) is a multifaceted condition characterised by insulin resistance, dyslipidemia, central obesity and hypertension, significantly elevating the risks of cardiovascular diseases and type 2 diabetes. This review aims to elucidate the bidirectional interplay between anaesthetic agents and MS, highlighting the mutual influence
Yuying Huang, Qinghai Lan, Yijian Chen, Youchun Li, Baolin Zhong, Yuxin Zhan, Simin Deng   +6 more
wiley   +1 more source

A continuum model for the dynamics of the phase transition from slow-wave sleep to REM sleep [PDF]

, 2010
Previous studies have shown that activated cortical states (awake and rapid eye-movement (REM) sleep), are associated with increased cholinergic input into the cerebral cortex.
Li, Xiaoli, Sleigh, James W., Steyn-Ross, D. Alistair, Steyn-Ross, Moira L., Voss, Logan J., Wilson, Marcus T.   +5 more
core   +2 more sources

Characterizing optogenetically mediated rebound effects in anaesthetized mouse primary visual cortex

The Journal of Physiology, Volume 603, Issue 16, Page 4609-4636, 15 August 2025.
Abstract figure legend Many studies of cortical circuits use optogenetic activation of inhibitory interneurons to suppress pyramidal cell activity, but after the light is turned off pyramidal cells sometimes show excess spiking, which is called a post‐inhibitory rebound.
Jared T. Shapiro, Nicole M. Michaud, Nathan A. Crowder   +2 more
wiley   +1 more source

Vasopressin‐Sensitive Aqp2 Regulation Mediated by the TAZ‐NR4A1 Axis in Renal Collecting Duct Cells

The FASEB Journal, Volume 39, Issue 13, 15 July 2025.
The TAZ‐NR4A1 axis was identified as a critical regulator of vasopressin‐induced AQP2 expression, essential for water homeostasis. Conditional TAZ‐knockout mice showed polyuria and a significant decrease in AQP2 expression in collecting ducts. In mpkCCDc11 cells, TAZ knockdown significantly impaired vasopressin‐mediated AQP2 expression independently of
Hong Seok Choi, Hyo‐Ju Jang, Wan‐Young Kim, Sun Ah Park, Euijung Park, Hyun Jun Jung, Tae‐Hwan Kwon   +6 more
wiley   +1 more source

The Role of Inhaled Anesthetics in Tumorigenesis and Tumor Immunity

Cancer Management and Research, 2020
Yichi Xu, Wenxiao Jiang, Shangdan Xie, Fang Xue, Xueqiong Zhu Department of Obstetrics and Gynecology, The Second Affiliated Hospital of Wenzhou Medical University, Wenzhou, People’s Republic of ChinaCorrespondence: Xueqiong ZhuDepartment of ...
Xu Y, Jiang W, Xie S, Xue F, Zhu X
doaj  

Single‐Cell Insights Into Cellular Response in Abdominal Aortic Occlusion‐Induced Hippocampal Injury

CNS Neuroscience &Therapeutics, Volume 31, Issue 1, January 2025.
In this study, single‐cell RNA sequencing (scRNA‐seq) was used to analyze the cellular response in the hippocampus of a mouse model with abdominal aortic occlusion (AAO) injury. We identified changes in cell proportion, including astrocytes and oligodendrocyte precursor cells (OPCs), and observed gene expression changes associated with neurogenesis and
Changhong Ren, Ling Kui, Jun Xu, Fang Tong, Xiaojie Wang, Jianping Ma, Xiaomei Tian, Guoyun Wang, Feng‐Yong Liu, Sijie Li, Xunming Ji   +10 more
wiley   +1 more source

Nausea and vomiting after general anesthesia with halothane or isoflurane A double blind randomized trial [PDF]

, 2005
Background: Postoperative nausea and vomiting (PONV) is potentially dangerous and causes morbidity and excessive costs to the patients. Prior investigators have reported controversies about halothane- and isoflurane-induced PONV, thus, the present study ...
Arti, HamidReza., Assari, Shervin., Davoudi, Amir Masoud., Madineh, Hossein., Moghani Lankarani, Maryam.   +4 more
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