Results 31 to 40 of about 3,437 (189)

Functional analyses reveal extensive RRE plasticity in primary HIV-1 sequences selected under selective pressure. [PDF]

PLoS ONE, 2014
BackgroundHIV-1 Rev response element (RRE) is a functional region of viral RNA lying immediately downstream to the junction of gp120 and gp41 in the env coding sequence.
Francesc Cunyat, Nancy Beerens, Elisabet García, Bonaventura Clotet, Jørgen Kjems, Cecilia Cabrera   +5 more
doaj   +1 more source

Discontinuation of enfuvirtide in heavily pretreated HIV-infected individuals

, 2009
BACKGROUND: Enfuvirtide was shown to be highly effective in treatment- experienced patients. Data on discontinuation of enfuvirtide and switch to new antiretroviral drugs are scarce.
Fux, Christoph A., Battegay, Manuel, Fux, Christoph A, Weber, R, Vernazza, P, Cavassini, M., Swiss HIV Cohort Study,, Elzi, L., Cavassini, M, Bernasconi, E, Vernazza, P., Battegay, M., Bernasconi, Enos, Fux, C. A., Weber, R., Elzi, L, Hirschel, Bernard, Kaufmann, G., Fux, C A, Kaufmann, Gilbert, Elzi, Luigia, Hirschel, B, Vernazza, Pietro, Fux, C.A., Kaufmann, G, Battegay, M, Weber, Rainer, Hirschel, B., Cavassini, Matthias, Bernasconi, E.   +29 more
core   +1 more source

Enfuvirtide-Protoporphyrin IX Dual-Loaded Liposomes: In Vitro Evidence of Synergy against HIV‑1 Entry into Cells

, 2019
We have developed a nanocarrier consisting of large unilamellar vesicles (LUVs) for combined delivery of two human immunodeficiency virus type 1 (HIV-1) entry inhibitors, enfuvirtide (ENF) and protoporphyrin IX (PPIX).
Miguel A. R. B. Castanho (7295609), Iris Cadima-Couto (221131), Astrid Walrant (344986), Françoise Illien (8157801), David Andreu (105466), Toni Todorovski (6526019), Ana Salomé Veiga (2054716), Tiago N. Figueira (5782010), Marco M. Domingues (368546), Sandrine Sagan (246380)   +9 more
core   +1 more source

Chimeric Human Papillomavirus-16 Virus-like Particles Presenting P18I10 and T20 Peptides from HIV-1 Envelope Induce HPV16 and HIV-1-Specific Humoral and T Cell-Mediated Immunity in BALB/c Mice

Vaccines, 2022
In this study, the HIV-1 P18I10 CTL peptide derived from the V3 loop of HIV-1 gp120 and the T20 anti-fusion peptide of HIV-1 gp41 were inserted into the HPV16 L1 capsid protein to construct chimeric HPV:HIV (L1:P18I10 and L1:T20) VLPs by using the ...
Chun-Wei Chen, Narcís Saubi, Athina Kilpeläinen, Joan Joseph-Munné   +3 more
doaj   +1 more source

Extracellular secretion of a recombinant therapeutic peptide by Bacillus halodurans utilizing a modified flagellin type III secretion system

Microbial Cell Factories, 2011
Background Through modification of the flagellin type III secretion pathway of Bacillus halodurans heterologous peptides could be secreted into the medium as flagellin fusion monomers.
Nxumalo Nolwandle P, Crampton Michael C, Berger Eldie, Louw Maureen E   +3 more
doaj   +1 more source

An Artificial Peptide-Based Bifunctional HIV-1 Entry Inhibitor That Interferes with Viral Glycoprotein-41 Six-Helix Bundle Formation and Antagonizes CCR5 on the Host Cell Membrane

Viruses, 2023
Human immunodeficiency virus type 1 (HIV-1) is characterized by high variability and drug resistance. This has necessitated the development of antivirals with a new chemotype and therapy.
Chao Wang, Qing Li, Lujia Sun, Xinling Wang, Huan Wang, Wenpeng Zhang, Jiahui Li, Yang Liu, Lu Lu, Shibo Jiang   +9 more
doaj   +1 more source

Backbone Protecting Groups for Enhanced Peptide and Protein Synthesis

Angewandte Chemie, Volume 137, Issue 33, August 11, 2025.
This review provides a comprehensive account of the use of backbone N‐protecting groups in peptide synthesis. It includes detailed synthetic methods relating to their introduction and removal and their application to “difficult” peptides and proteins of biological significance in both academic and industry contexts.
Samuel J. Paravizzini, Linda M. Haugaard‐Kedström, Craig A. Hutton, John A. Karas   +3 more
wiley   +2 more sources

The rare HIV-1 gp41 mutations 43T and 50V elevate enfuvirtide resistance levels of common enfuvirtide resistance mutations that did not impact susceptibility to sifuvirtide

, 2010
Mutations that are selected at low frequency and/or reside outside the enfuvirtide target region, amino acid 36-45 of gp41, might still be important determinants for drug resistance.
Vandamme, Anne-Mieke, Dekeersmaeker, Nathalie, Van Laethem, Kristel, Kabeya, Kabamba, Megens, Sarah, De Wit, Stéphane, Balzarini, Jan, Covens, Kris   +7 more
core   +1 more source

Cyclic Peptide Conformational Landscapes Through the Lens of Mass Spectrometry and Orthogonal Spectroscopy

Journal of Mass Spectrometry, Volume 61, Issue 5, May 2026.
ABSTRACT Cyclic peptides occupy a structurally dynamic region of chemical space, where function often arises from ensembles rather than a single dominant fold. Closed backbones, frequent N‐methylation, heteroatoms, unnatural amino acids, and a strong propensity for metal coordination create dense conformational and coordination landscapes that ...
Emmanuel Nkyaagye, Happy Abena Safoah, Thanh D. Do   +2 more
wiley   +1 more source

Tenofovir, Interferon Pathways, and Mucosal Immunity: Implications for People Living With HIV

American Journal of Reproductive Immunology, Volume 95, Issue 5, May 2026.
ABSTRACT Background Antiretroviral therapy (ART) suppresses HIV replication and protects people living with HIV (PLWH) from progressing to AIDS. However, despite ART, many PLWH experience chronic immune activation, which contributes to premature aging and non‐AIDS‐related comorbidities. One reason for this chronic immune activation (CIA) is HIV and its
Florian Hladik, Sean M. Hughes, Claire N. Levy, Rachel L. Creighton, Romel Mackelprang, Germán G. Gornalusse   +5 more
wiley   +1 more source