Results 1 to 10 of about 13,523 (178)
Tracking the protein conformational motions driving HIV-1 membrane fusion [PDF]
Scientific ReportsHIV-1 Env (trimeric gp120/gp41) is the surface protein responsible for membrane fusion. The Env binds to the receptor proteins, which induces gp120 shedding leading to conformational changes of gp41 from the pre-fusion to post-fusion state, allowing its ...
Ilona C. Unarta +2 more
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Neutralizing Antibodies Targeting HIV-1 gp41 [PDF]
Viruses, 2020 HIV-1 vaccine research has obtained an enormous boost since the discovery of many broadly neutralizing antibodies (bnAbs) targeting all accessible sites on the HIV-1 envelope glycoprotein (Env).
Christophe Caillat +3 more
doaj +4 more sources
Virus Research, 1999 A newly sequenced Anticarsia gemmatalis multiple nucleopolyhedrovirus (AgMNPV) gp41 gene was used to reconstruct the phylogeny for gp41 by comparison with Autographa californica MNPV, Bombyx mori MNPV, Helicoverpa zea single nucleopolyhedrovirus (SNPV), Lymantria dispar MNPV, Orgyia pseudotsugata MNPV and Spodoptera frugiperda MNPV. The 3.5 kb fragment
James E Maruniak
exaly +4 more sources
Biochimica Et Biophysica Acta - Biomembranes, 2004 The identification of membrane-active regions of the ectodomain of the HIV-1 envelope glycoprotein gp41 has been made by determining the effect on membrane integrity of a 15-mer gp41-derived peptide library. By monitoring the effect of this peptide library on membrane leakage, we have identified three regions on the gp41 ectodomain with membrane ...
MIGUEL R Moreno, JOSÉ Villalaín
exaly +3 more sources
Frontiers in Immunology, 2022 Many participants in HIV-1 vaccine trials, who have not previously been exposed to or vaccinated against HIV-1, display serum immunoglobulin antibodies that bind the gp41 region of HIV-1 envelope prior to vaccination.
Koshlan Mayer-Blackwell +15 more
doaj +1 more source
Functional, non-clonal IgMa-restricted B cell receptor interactions with the HIV-1 envelope gp41 membrane proximal external region. [PDF]
PLoS ONE, 2009 The membrane proximal external region (MPER) of HIV-1 gp41 has several features that make it an attractive antibody-based vaccine target, but eliciting an effective gp41 MPER-specific protective antibody response remains elusive. One fundamental issue is
Laurent Verkoczy +8 more
doaj +1 more source
Immunogens Modeling a Fusion-Intermediate Conformation of gp41 Elicit Antibodies to the Membrane Proximal External Region of the HIV Envelope Glycoprotein. [PDF]
PLoS ONE, 2015 The membrane proximal external region (MPER) of the gp41 subunit of the HIV-1 envelope glycoprotein (Env) contains determinants for broadly neutralizing antibodies and has remained an important focus of vaccine design. However, creating an immunogen that
Russell Vassell +12 more
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Asymmetric deactivation of HIV-1 gp41 following fusion inhibitor binding. [PDF]
PLoS Pathogens, 2009 Both equilibrium and nonequilibrium factors influence the efficacy of pharmaceutical agents that target intermediate states of biochemical reactions. We explored the intermediate state inhibition of gp41, part of the HIV-1 envelope glycoprotein complex ...
Kristen M Kahle +2 more
doaj +1 more source
PLoS Pathogens, 2023 Recent HIV-1 vaccine development has centered on "near native" soluble envelope glycoprotein (Env) trimers that are artificially stabilized laterally (between protomers) and apically (between gp120 and gp41).
Tommy Tong +7 more
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Antigenic and immunosuppressive properties of a trimeric recombinant transmembrane envelope protein gp41 of HIV-1. [PDF]
PLoS ONE, 2017 The transmembrane envelope (TM) protein gp41 of the human immunodeficiency virus-1 (HIV-1) plays an important role during virus infection inducing the fusion of the viral and cellular membranes.
Michael Mühle +6 more
doaj +1 more source