Results 11 to 20 of about 13,523 (178)

Investigating the role of a conserved hydrophobic pocket of gp41 in the anti-HIV activity of fusion inhibitors. [PDF]

Protein Sci
Abstract Membrane fusion between HIV and host cells requires interaction between the N‐terminal and C‐terminal repeat regions (NHR and CHR) of the gp41 envelope subunit. A deep hydrophobic pocket (HP) on the surface of NHR is considered crucial in this interaction.
Polo-Megías D, Cano-Muñoz M, Sánchez-Martínez L, Lestani S, Moog C, Decoville T, Salinas-García MC, Gavira JA, Cámara-Artigas A, Conejero-Lara F.   +9 more
europepmc   +2 more sources

Oligomerization of the hydrophobic heptad repeat of gp41 [PDF]

Journal of Virology, 1995
The transmembrane protein of human immunodeficiency virus type 1 (HIV-1) contains a leucine zipper-like (hydrophobic heptad) repeat which has been predicted to form an amphipathic alpha helix. To evaluate the potential of the hydrophobic heptad repeat to induce protein oligomerization, this region of gp41 has been cloned into the bacterial expression ...
H B, Bernstein, S P, Tucker, S R, Kar, S A, McPherson, D T, McPherson, J W, Dubay, J, Lebowitz, R W, Compans, E, Hunter   +8 more
openaire   +2 more sources

Sensitive detection systems for infectious agents in xenotransplantation*

Xenotransplantation, EarlyView., 2020
Abstract Xenotransplantation of pig cells, tissues, or organs may be associated with transmission of porcine microorganisms, first of all of viruses, to the transplant recipient, potentially inducing a disease (zoonosis). I would like to define detection systems as the complex of sample generation, sample preparation, sample origin, time of sampling ...
Joachim Denner
wiley   +1 more source

Design and Properties of NCCG-gp41, a Chimeric gp41 Molecule with Nanomolar HIV Fusion Inhibitory Activity [PDF]

Journal of Biological Chemistry, 2001
The design and characterization of a chimeric protein, termed N(CCG)-gp41, derived from the ectodomain of human immunodeficiency virus (HIV), type I gp41 is described. N(CCG)-gp41 features an exposed trimeric coiled-coil comprising the N-terminal helices of the gp41 ectodomain.
J M, Louis, C A, Bewley, G M, Clore
openaire   +2 more sources

Induction of HIV neutralizing antibodies against the MPER of the HIV envelope protein by HA/gp41 chimeric protein-based DNA and VLP vaccines. [PDF]

PLoS ONE, 2011
Several conserved neutralizing epitopes have been identified in the HIV Env protein and among these, the MPER of gp41 has received great attention and is widely recognized as a promising target. However, little success has been achieved in eliciting MPER-
Ling Ye, Zhiyuan Wen, Ke Dong, Xi Wang, Zhigao Bu, Huizhong Zhang, Richard W Compans, Chinglai Yang   +7 more
doaj   +1 more source

HIV Transmembrane Glycoprotein Conserved Domains and Genetic Markers Across HIV-1 and HIV-2 Variants

Frontiers in Microbiology, 2022
HIV envelope transmembrane glycoproteins gp41 (HIV-1) and gp36 (HIV-2) present high variability and play a key role in the HIV-host cell membrane's fusion, as a target for human broadly neutralizing antibodies (bnAbs) and drugs.
Ana Valadés-Alcaraz, Roberto Reinosa, África Holguín   +2 more
doaj   +1 more source

gp41: HIV's shy protein [PDF]

Nature Medicine, 2004
The first X-ray crystal structures of gp41, the protein that mediates fusion of HIV-1 to target cells, were solved in the mid-1990s. The structures provide a foundation for understanding viral entry and the mechanism of action of compounds that block fusion.
Zwick, Michael B, Saphire, Erica O, Burton, Dennis R   +2 more
openaire   +1 more source

DNA unwinding by ring-shaped T4 helicase gp41 is hindered by tension on the occluded strand. [PDF]

PLoS ONE, 2013
The replicative helicase for bacteriophage T4 is gp41, which is a ring-shaped hexameric motor protein that achieves unwinding of dsDNA by translocating along one strand of ssDNA while forcing the opposite strand to the outside of the ring.
Noah Ribeck, Omar A Saleh
doaj   +1 more source

Characterization of HIV-1 envelope gp41 genetic diversity and functional domains following perinatal transmission

Retrovirology, 2006
Background HIV-1 envelope gp41 is a transmembrane protein that promotes fusion of the virus with the plasma membrane of the host cells required for virus entry. In addition, gp41 is an important target for the immune response and development of antiviral
Davis Tiffany, Sundaravaradan Vasudha, Mehta Roshni, Ramakrishnan Rajesh, Ahmad Nafees   +4 more
doaj   +1 more source

Selected amino acid mutations in HIV-1 B subtype gp41 are Associated with Specific gp120_V3 signatures in the regulation of Co-Receptor usage

Retrovirology, 2011
Background The third variable loop (V3) of the HIV-1 gp120 surface protein is a major determinant of cellular co-receptor binding. However, HIV-1 can also modulate its tropism through other regions in gp120, such as V1, V2 and C4 regions, as well as in ...
D'Arrigo Roberta, Svicher Valentina, Mercurio Fabio, Dimonte Salvatore, Perno Carlo-Federico, Ceccherini-Silberstein Francesca   +5 more
doaj   +1 more source