Results 31 to 40 of about 13,523 (178)
Evolution of the HIV-1 envelope glycoproteins with a disulfide bond between gp120 and gp41
Retrovirology, 2004 Background We previously described the construction of an HIV-1 envelope glycoprotein complex (Env) that is stabilized by an engineered intermolecular disulfide bond (SOS) between gp120 and gp41.
Caffrey Michael +5 more
doaj +1 more source
HIV-1 Envelope Glycoprotein Trafficking and Viral Transmission
Proceedings, 2020 HIV-1 encodes an envelope glycoprotein complex (Env) containing a long cytoplasmic tail (CT) harboring trafficking motifs implicated in Env incorporation into virions.
Melissa Victoria Fernandez +5 more
doaj +1 more source
Frontiers in Microbiology, 2013 The role of antibodies in protecting the host from human immunodeficiency virus type 1 (HIV-1) infection is of considerable interest, particularly because the RV144 trial results suggest that antibodies contribute to protection.
Takeo eKuwata +4 more
doaj +1 more source
Scientific Reports, 2020 During the first steps of HIV infection the Env subunit gp41 is thought to establish contact between the membranes and to be the main driver of fusion.
Christopher Aisenbrey +2 more
doaj +1 more source
Cytotoxicity of HIV-gp41 segments expressed inE. coli [PDF]
Chinese Science Bulletin, 2004 The failed attempt to express HIV-gp41 inE. coli led to the investigation of HIV-gp41 segments, which is responsible for the toxicity toE. coli cells. A series of deletion mutants containing different regions ofgp41 gene were constructed and expressed inE. coli BL21(DE3) strain.
Yuan, Yuhua +5 more
openaire +2 more sources
Amphipathic Properties of HIV-1 gp41 Fusion Inhibitors [PDF]
Current Topics in Medicinal Chemistry, 2011 Small molecule inhibition of HIV fusion has been an elusive goal, despite years of effort by both pharmaceutical and academic laboratories. In this review, we will discuss the amphipathic properties of both peptide and small molecule inhibitors of gp41-mediated fusion.
Miriam, Gochin, Guangyan, Zhou
openaire +2 more sources
Maturation-induced cloaking of neutralization epitopes on HIV-1 particles. [PDF]
PLoS Pathogens, 2011 To become infectious, HIV-1 particles undergo a maturation process involving proteolytic cleavage of the Gag and Gag-Pol polyproteins. Immature particles contain a highly stable spherical Gag lattice and are impaired for fusion with target cells.
Amanda S Joyner +3 more
doaj +1 more source
Molecules, 2022 Despite the enormous efforts made to develop other fusion inhibitors for HIV, the enfuvirtide (known as T20) peptide is the only approved HIV-1 inhibitory drug so far.
Ahmed L. Alaofi
doaj +1 more source
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 2001 In human immunodeficiency virus (HIV) the viral envelope proteins gp41 and gp120 form a non-covalent complex, which is a potential target for AIDS therapies. In addition gp41 plays a possible role in HIV infection of B cells via the complement system.
openaire +2 more sources
AlphaFold2‐Guided Cyclic Peptide Stabilizer Design to Target Protein–Protein Interactions
Proteins: Structure, Function, and Bioinformatics, Volume 94, Issue 7, Page 1356-1370, July 2026.ABSTRACT The control and modulation of protein–protein interactions (PPIs) is of central importance for the majority of biological processes and most biomedical applications. Stabilization of PPIs, besides inhibition, is of growing pharmaceutical interest.
Niklas Halbwedl, Martin Zacharias
wiley +1 more source