Results 31 to 40 of about 13,547 (178)
Scientific Reports, 2020 During the first steps of HIV infection the Env subunit gp41 is thought to establish contact between the membranes and to be the main driver of fusion.
Christopher Aisenbrey +2 more
doaj +1 more source
Frontiers in Microbiology, 2013 The role of antibodies in protecting the host from human immunodeficiency virus type 1 (HIV-1) infection is of considerable interest, particularly because the RV144 trial results suggest that antibodies contribute to protection.
Takeo eKuwata +4 more
doaj +1 more source
HIV-1 Envelope Glycoprotein Trafficking and Viral Transmission
Proceedings, 2020 HIV-1 encodes an envelope glycoprotein complex (Env) containing a long cytoplasmic tail (CT) harboring trafficking motifs implicated in Env incorporation into virions.
Melissa Victoria Fernandez +5 more
doaj +1 more source
Maturation-induced cloaking of neutralization epitopes on HIV-1 particles. [PDF]
PLoS Pathogens, 2011 To become infectious, HIV-1 particles undergo a maturation process involving proteolytic cleavage of the Gag and Gag-Pol polyproteins. Immature particles contain a highly stable spherical Gag lattice and are impaired for fusion with target cells.
Amanda S Joyner +3 more
doaj +1 more source
Molecules, 2022 Despite the enormous efforts made to develop other fusion inhibitors for HIV, the enfuvirtide (known as T20) peptide is the only approved HIV-1 inhibitory drug so far.
Ahmed L. Alaofi
doaj +1 more source
Alanine Scanning Mutants of the HIV gp41 Loop [PDF]
Journal of Biological Chemistry, 2005 Based on mutagenesis and structural studies of human immunodeficiency virus (HIV) envelope proteins, the loop region of gp41 is thought to directly interact with gp120. The importance of the HIV gp41 loop region to envelope function has been systematically examined by alanine scanning of all gp41 loop residues and the subsequent characterization of the
Amy, Jacobs +3 more
openaire +2 more sources
Receptor Activation of HIV-1 Env Leads to Asymmetric Exposure of the gp41 Trimer.
PLoS Pathogens, 2016 Structural rearrangements of HIV-1 glycoprotein Env promote viral entry through membrane fusion. Env is a symmetric homotrimer with each protomer composed of surface subunit gp120 and transmembrane subunit gp41.
Mukta D Khasnis +3 more
doaj +1 more source
Viruses, 2022 Human Immunodeficiency virus (HIV-1) fusion is mediated by glycoprotein-41, a protein that has not been widely exploited as a drug target. Small molecules directed at the gp41 ectodomain have proved to be poorly drug-like, having moderate efficacy, high ...
Li He +6 more
doaj +1 more source
ChemMedChem, Volume 21, Issue 15, 14 August 2026.Temporins, among antimicrobial peptides, are short frog‐derived molecules with potent antibacterial activity. This review highlights chemical optimization strategies applied to temporins A–L, showing how sequence tuning modulates structure, stability, and selectivity, enabling improved activity against resistant pathogens.
Ida Boccino +2 more
wiley +1 more source
HIV-1 gp41 and TCRalpha trans-membrane domains share a motif exploited by the HIV virus to modulate T-cell proliferation. [PDF]
PLoS Pathogens, 2010 Viruses have evolved several strategies to modify cellular processes and evade the immune response in order to successfully infect, replicate, and persist in the host.
Tomer Cohen +4 more
doaj +1 more source