Results 51 to 60 of about 24,285 (259)
HIV-1 Envelope Glycoprotein Trafficking and Viral Transmission
Proceedings, 2020 HIV-1 encodes an envelope glycoprotein complex (Env) containing a long cytoplasmic tail (CT) harboring trafficking motifs implicated in Env incorporation into virions.
Melissa Victoria Fernandez +5 more
doaj +1 more source
Scientific Reports, 2017 The HIV-1 gp41 Membrane Proximal External Region (MPER) is recognized by broadly neutralizing antibodies and represents a promising vaccine target. However, MPER immunogenicity and antibody activity are influenced by membrane lipids.
L. M. Molinos-Albert +17 more
semanticscholar +1 more source
Modulation of cytokine release by recombinant gp41.
, 2017 a) A cytokine array was performed with supernatants of PBMCs previously incubated with PBS, 5 EU/ml of LPS or 1 μg of purified gp41 for 24 hours. Cytokines specifically altered by incubation with LPS, gp41 or both LPS and gp41 are framed in red, blue and
Daniel Stern (213946) +6 more
core +1 more source
Inhibition of HIV Entry by Targeting the Envelope Transmembrane Subunit gp41
Current HIV Research, 2016 Background The transmembrane subunit of the HIV envelope protein, gp41 is a vulnerable target to inhibit HIV entry. There is one fusion inhibitor T20 (brand name: Fuzeon, generic name: enfuvirtide) available by prescription.
H. Yi +3 more
semanticscholar +1 more source
Maturation-induced cloaking of neutralization epitopes on HIV-1 particles. [PDF]
PLoS Pathogens, 2011 To become infectious, HIV-1 particles undergo a maturation process involving proteolytic cleavage of the Gag and Gag-Pol polyproteins. Immature particles contain a highly stable spherical Gag lattice and are impaired for fusion with target cells.
Amanda S Joyner +3 more
doaj +1 more source
Advanced Science, EarlyView.During kainic acid‐induced epileptogenesis, astrocyte‐associated ATP‐binding cassette transporter A1 (ABCA1) and apolipoprotein E (APOE) responses accompany ectopic neurons and exploratory lipid alterations. In separate cohorts, bexarotene pretreatment and treatment on days 14–21 are associated with fewer ectopic hilar neurons and lower chronic seizure
Lu Chen +10 more
wiley +1 more source
Diversion of HIV-1 Vaccine-induced Immunity by gp41-Microbiota Cross-reactive Antibodies
Science, 2015 Microbiota can mislead antibodies Unlike the response to many viral infections, most people do not produce antibodies capable of clearing HIV-1. Non-neutralizing antibodies that target HIV-1's envelope glycoprotein (Env) typically dominate the response ...
W. Williams +45 more
semanticscholar +1 more source
Alanine Scanning Mutants of the HIV gp41 Loop [PDF]
Journal of Biological Chemistry, 2005 Based on mutagenesis and structural studies of human immunodeficiency virus (HIV) envelope proteins, the loop region of gp41 is thought to directly interact with gp120. The importance of the HIV gp41 loop region to envelope function has been systematically examined by alanine scanning of all gp41 loop residues and the subsequent characterization of the
Amy, Jacobs +3 more
openaire +2 more sources
Contribution of endosomal proteins EHD1 and EHD4 to the HIV‐1 replication cycle
The FEBS Journal, EarlyView.EHD1 and EHD4, two key trafficking proteins, regulate multiple stages of HIV‐1 infection: In producer cells, they help produce fully infectious virus particles, regulate Envelope protein incorporation in a cell‐type‐dependent manner, and limit the accumulation of antiviral IFITM proteins in virions.
Grégory Pacini +4 more
wiley +1 more source
, 2016 Comparison between gp41 and gp41-p1-based immunoassay and LAg-Avidity EIA for identification of recent and long-term HIV-1 infection.
Shouyi Yu (3324669) +6 more
core +1 more source