Results 51 to 60 of about 13,523 (178)

A Comprehensive Analysis of the T and B Lymphocytes Repertoire Shaped by HIV Vaccines

Frontiers in Immunology, 2018
The exploitation of various human immunodeficiency virus type-1 (HIV-1) vaccines has posed great challenges for the researchers in precisely evaluating the vaccine-induced immune responses, however, the understanding of vaccination response suffers from ...
Longlong Wang, Longlong Wang, Longlong Wang, Wei Zhang, Wei Zhang, Liya Lin, Liya Lin, Xiao Li, Xiao Li, Nitin K. Saksena, Nitin K. Saksena, Jinghua Wu, Jinghua Wu, Shiyu Wang, Shiyu Wang, Shiyu Wang, Joseph G. Joyce, Xiuqing Zhang, Xiuqing Zhang, Huanming Yang, Huanming Yang, Jian Wang, Jian Wang, I-Ming Wang, Xiao Liu, Xiao Liu   +25 more
doaj   +1 more source

Core Structure of gp41 from the HIV Envelope Glycoprotein [PDF]

Cell, 1997
The envelope glycoprotein of human immunodeficiency virus type 1 (HIV-1) consists of a complex of gp120 and gp41. gp120 determines viral tropism by binding to target-cell receptors, while gp41 mediates fusion between viral and cellular membranes. Previous studies identified an alpha-helical domain within gp41 composed of a trimer of two interacting ...
Chan, David C., Fass, Deborah, Berger, James M., Kim, Peter S.   +3 more
openaire   +3 more sources

Liquid–Liquid Phase Separation in Viral Infection and Immunology

MedComm, Volume 7, Issue 4, April 2026.
LLPS organizes viral replication and antiviral immunity. Viruses hijack LLPS to form replication factories and evade immune sensors, while hosts assemble LLPS‐driven signaling hubs (e.g., MAVS, RIG‐I, and SGs) to amplify interferon responses. Targeting these condensate interfaces offers novel therapeutic strategies against infectious diseases ...
Jiuzhi Xu, Lan Bai, Bin Wang, Hai Song, Long Zhang, Fangfang Zhou   +5 more
wiley   +1 more source

TLR10 Senses HIV-1 Proteins and Significantly Enhances HIV-1 Infection

Frontiers in Immunology, 2019
Toll-like receptors (TLRs) play a crucial role in innate immunity and provide a first line of host defense against invading pathogens. Of the identified human TLRs, TLR10 remains an orphan receptor whose ligands and functions are poorly understood.
Bethany M. Henrick, Bethany M. Henrick, Xiao-Dan Yao, Muhammad Atif Zahoor, Alash'le Abimiku, Sophia Osawe, Kenneth L. Rosenthal   +6 more
doaj   +1 more source

HIV-1 Envelope Protein gp41: An NMR Study of Dodecyl Phosphocholine Embedded gp41 Reveals a Dynamic Prefusion Intermediate Conformation [PDF]

Structure, 2014
Human immunodeficiency viral (HIV-1) fusion is mediated by the viral envelope gp120/gp41 complex (ENVelope glycoprotein). After gp120 shedding, gp41 is exposed and elicits membrane fusion via a cascade of conformational changes. In contrast to prefusion and postfusion conformation, little is known about any intermediate conformation.
Lakomek, N., Kaufman, J., Stahl, S., Wingfield, P.   +3 more
openaire   +3 more sources

Generating Ultra‐Fast Protein trans‐Splicing of a Cysteine‐Less and Semisynthetic Split Intein for Chemical Protein Labeling

ChemBioChem, Volume 27, Issue 6, 27 March 2026.
Protein trans‐splicing (PTS) by split inteins is a powerful approach for protein semisynthesis to generate proteins with site‐specific modifications that are difficult or impossible to introduce biosynthetically. Here, the authors report the first ultra‐fast and cysteine‐less split intein with a sufficiently short N‐terminal fragment amenable to ...
Christoph Humberg, Tobias M. E. Terhorst, Tim Pasch, Henning D. Mootz   +3 more
wiley   +1 more source

Nano‐ and Micro‐Sized Solid Materials Used as Antiviral Agents

Advanced Functional Materials, Volume 36, Issue 26, 30 March 2026.
Due to the rise of viral infections in humans and possible viral outbreaks, the use of nano‐ or micro‐sized materials as antiviral agents is rapidly increasing. This review explores their antiviral properties against RNA and DNA viruses, either as a prevention or a treatment tool, by delving into their mechanisms of action and how to properly assess ...
Orfeas‐Evangelos Plastiras, Imelda Raczkiewicz, Peggy Bouquet, Jean‐Philippe Dacquin, Jeremy Dhainaut, Anne Goffard, Christophe Volkringer   +6 more
wiley   +1 more source

The development of HIV vaccines targeting gp41 membrane-proximal external region (MPER): challenges and prospects

Protein & Cell, 2018
A human immunodeficiency virus type-1 (HIV-1) vaccine which is able to effectively prevent infection would be the most powerful method of extinguishing pandemic of the acquired immunodeficiency syndrome (AIDS).
Huan Liu, Xiaojie Su, Lulu Si, Lu Lu, Shibo Jiang   +4 more
doaj   +1 more source

Antiviral properties of two trimeric recombinant gp41 proteins [PDF]

Retrovirology, 2006
Abstract Background As it is the very first step of the HIV replication cycle, HIV entry represents an attractive target for the development of new antiviral drugs. In this context, fusion inhibitors are the third class of anti-HIV drugs to be used for treatment, in combination with nucleoside analogues and ...
Delcroix-Genête, Delphine, Quan, Phenix-Lan, Roger, Marie-Gaëlle, Hazan, Uriel, Nisole, Sébastien, Rousseau, Cécile   +5 more
openaire   +5 more sources

Membrane Fusion‐Inspired Nanomaterials: Emerging Strategies for Infectious Disease and Cancer Diagnostics

Advanced Healthcare Materials, Volume 15, Issue 6, 9 February 2026.
Membrane fusion‐inspired nanomaterials offer transformative potential in diagnostics by mimicking natural fusion processes to achieve highly sensitive and specific detection of disease biomarkers. This review highlights recent advancements in nanomaterial functionalization strategies, signal amplification systems, and stimuli‐responsive fusion designs,
Sojeong Lee, Khulan Nyamzaya, Jueun Han, Yejin Song, Jihee Lee, Jung Hyun Jo, Seungmin Bang, Eun‐Kyung Lim, Seungjoo Haam, Eunjung Kim   +9 more
wiley   +1 more source