Results 61 to 70 of about 13,547 (178)

Recent Developments in HIV Antivirals: The Prospect of Prophylactic Drugs to Change the Pandemic

Microbial Biotechnology, Volume 19, Issue 2, February 2026.
Replication cycle of HIV‐1. The scheme provides an overview from virus entry over reverse transcription of viral RNA into viral DNA, provirus DNA integration into the host genome, genome expression by transcription and translation, proteolytic processing of the viral polyproteins, viral maturation to viral release from the cell. The various targets for
Harald Brüssow
wiley   +1 more source

Combination of anti-retroviral drugs and radioimmunotherapy specifically kills infected cells from HIV infected individuals

Frontiers in Medicine, 2016
Eliminating virally infected cells is an essential component of any HIV eradication strategy. Radioimmunotherapy (RIT), a clinically established method for killing cells using radiolabeled antibodies, was recently applied to target HIV-1 gp41 antigen ...
Dina Tsukrov, Alicia McFarren, Alfred Morgenstern, Frank Bruchertseifer, Eugene Dolce, Miroslaw K Gorny, Susan Zolla-Pazner, Joan W Berman, Ellie Schoenbaum, Barry S Zingman, Arturo Casadevall, Ekaterina Dadachova   +11 more
doaj   +1 more source

Enhanced Clearance of HIV‐1 Broadly Neutralizing Antibody VRC07‐523‐LS During Viremia: Influences on Trial Design and Analysis

Clinical and Translational Science, Volume 19, Issue 2, February 2026.
ABSTRACT Broadly neutralizing antibodies (BNAb) are capable of neutralizing multiple HIV‐1 strains through the targeting of conserved epitopes. This study's objective was to quantify the pharmacokinetic (PK) parameters describing the distribution and elimination of the BNAb VRC07‐523‐LS in people with HIV (PWH), and to identify the influence of viral ...
Nicholas M. Smith, Brian M. Ho, Katharine J. Bar, Lucio Gama, Gabrielle Dziubla, Richard A. Koup, Michael Pensiero, Leonid Serebryannyy, Marina Caskey, Timothy J. Wilkin, Troy D. Wood, Gene D. Morse, Charles S. Venuto, Ray Cha, Qing Ma   +14 more
wiley   +1 more source

HERV‐K TM Subunit Elicits CD8+ T Cell Anergy and Tumor Immune Evasion via Targeting CD3 Coreceptor ε in AML and PDAC

Advanced Science, Volume 13, Issue 1, 5 January 2026.
Novel viral immune checkpoint K‐TM subunit is aberrantly expressed in CD8+ T cells and enriched in sera of cancer patients, inducing CD8+ T cell anergy and eliciting potent tumor immune escape in mouse model. Mechanistically, K‐TM directly targets and induces the phosphorylation of CD3ε receptor.
Mengyuan Li, Shuwen Zheng, Qinyuan Gong, Zhaoxing Wu, Wen Lei, Wanyue Cao, Ping Wang, Xuzhao Zhang, Wenbin Qian, Yun Liang, Ying Lu, Fenglin Li, Qi Zhang, Rongzhen Xu   +13 more
wiley   +1 more source

Meeting Review: 2018 International Workshop on Structure and Function of the Lentiviral gp41 Cytoplasmic Tail

Viruses, 2018
Recent developments in defining the role of the lentiviral envelope glycoprotein (Env) cytoplasmic tail (CT) in Env trafficking and incorporation into virus particles have advanced our understanding of viral replication and transmission.
Melissa V. Fernandez, Eric O. Freed
doaj   +1 more source

A Role for Baculovirus GP41 in Budded Virus Production

Virology, 1997
Insect cells infected with tsB1074, a temperature-sensitive mutant of Autographa californica nuclear polyhedrosis virus, exhibit a "single-cell-infection" phenotype whereby the infection progresses through the very late phase culminating in occlusion body formation, but neighboring cells do not become infected.
Olszewski, Julie, Miller, Lois K.
openaire   +2 more sources

How Vaccinating People Living With HIV May Guide bNAb‑Based Vaccines

Journal of the International AIDS Society, Volume 29, Issue 5, May 2026.
Penny L. Moore, Leonidas Stamatatos, Alexandra Trkola   +2 more
wiley   +1 more source

Carbon‐13 Centerband‐Only Detection of EXchange with Dynamic Nuclear Polarization

ChemPhysChem, Volume 27, Issue 2, January 2026.
A combination of dynamic nuclear polarization‐based signal enhancement and cryogenic conditions enables counting of spins in a cluster in proteins using 13C‐Centerband‐Only Detection of EXchange when combined with background correction. Optionally, 13C‐depleted labeling of background spins further improves the method.
Abel Cherian Varkey, Kai Xue, Evgeny Nimerovsky, Stefan Becker, Loren B. Andreas   +4 more
wiley   +1 more source

Human gut microbiota is associated with HIV-reactive immunoglobulin at baseline and following HIV vaccination.

PLoS ONE, 2019
Antibodies that recognize commensal microbial antigens may be cross reactive with a part of the human immunodeficiency virus (HIV) envelope glycoprotein gp41. To improve understanding of the role of the microbiota in modulating the immune response to HIV
Jacob A Cram, Andrew J Fiore-Gartland, Sujatha Srinivasan, Shelly Karuna, Giuseppe Pantaleo, Georgia D Tomaras, David N Fredricks, James G Kublin   +7 more
doaj   +1 more source

Host and Viral Factors in HIV-Mediated Bystander Apoptosis

Viruses, 2017
Human immunodeficiency virus (HIV) infections lead to a progressive loss of CD4 T cells primarily via the process of apoptosis. With a limited number of infected cells and vastly disproportionate apoptosis in HIV infected patients, it is believed that ...
Himanshu Garg, Anjali Joshi
doaj   +1 more source