Results 61 to 70 of about 24,285 (259)
Molecular basis for epitope recognition by non-neutralizing anti-gp41 antibody F240
Scientific Reports, 2016 Antibody-dependent cell-mediated cytotoxicity (ADCC) by non-neutralizing antibodies (nnAbs) specific to the HIV envelope (Env) glycoproteins present at the surface of virus sensitized or infected cells plays a role in the effective adaptive immune ...
N. Gohain +12 more
semanticscholar +1 more source
HIV-1 gp41 and TCRalpha trans-membrane domains share a motif exploited by the HIV virus to modulate T-cell proliferation. [PDF]
PLoS Pathogens, 2010 Viruses have evolved several strategies to modify cellular processes and evade the immune response in order to successfully infect, replicate, and persist in the host.
Tomer Cohen +4 more
doaj +1 more source
Canonical Antibodies Adopt Distinct Binding Modes to Recognize Viral Glycan Shields
Advanced Science, Volume 13, Issue 61, 3 November 2026.Canonical Y‐shaped antibodies recognize viral glycan shields through adaptive Fab assembly states shaped by glycan organization and somatic hypermutation. Structural analyses ofbroadly neutralizing antibodies VRC35 and VRC36 across glycoproteins of HIV‐1, influenza, SARS‐CoV‐2, and Lassa viruses reveal distinct Fab assembly states, spanning monovalent,
Jiaxuan Cheng +71 more
wiley +1 more source
Production and purification of recombinant gp41 expressed in 293 cells.
, 2017 a) Schematical presentation of HIV gp41 and the fragment cloned into the pIRESneo vector to obtain pIRESneo-gp41. The vector is driven by the constitutive CMV promoter (CMV) and triggers expression of gp41 with a CD14 export signal, an N-terminal 8xHis ...
Daniel Stern (213946) +6 more
core +1 more source
Broad and potent HIV-1 neutralization by a human antibody that binds the gp41-120 interface
Nature, 2014 The isolation of human monoclonal antibodies is providing important insights into the specificities that underlie broad neutralization of HIV-1 (reviewed in ref. 1).
Jing-He Huang +28 more
semanticscholar +1 more source
Biochemical and immunological characterization of purified gp41.
, 2017 a) Glycosylation analysis of purified gp41. The protein was denatured and left untreated or incubated with Endoglycosidase H (EndoH) or with PNGase F (PNGase) as indicated.
Daniel Stern (213946) +6 more
core +1 more source
HIV-1 gp41 Fusion Intermediate: A Target for HIV Therapeutics
Journal of the Formosan Medical Association, 2010 Human immunodeficiency virus (HIV)-1 infection is initiated by the binding of gp120 envelope glyco-protein to its cell receptor (CD4) and a coreceptor (CXCR4 or CCR5), followed by a series of conformational changes in the gp41 transmembrane subunit ...
Chungen Pan, Shuwen Liu, Shibo Jiang
doaj +1 more source
Identification of a human protein-derived HIV-1 fusion inhibitor targeting the gp41 fusion core structure. [PDF]
PLoS ONE, 2013 The HIV-1 envelope glycoprotein (Env) gp41 plays a crucial role in the viral fusion process. The peptides derived from the C-terminal heptad repeat (CHR) of gp41 are potent HIV fusion inhibitors. However, the activity of these anti-HIV-1 peptides in vivo
Lijun Chao +8 more
doaj +1 more source
Vaccines, 2023 We are developing cytotoxic immunoconjugates (CICs) targeting the envelope protein (Env) of the Human Immunodeficiency Virus, type 1 (HIV) to purge the persistent reservoirs of viral infection.
Grant Klug +5 more
doaj +1 more source
Journal of Biomedical Sciences, 2016 Cryptococcus neoformans (Cn) is an important opportunistic pathogen in the immunocompromised people, including AIDS patients, which leads to fatal cryptococcal meningitis with high mortality rate.
Xiao-Long He +14 more
semanticscholar +1 more source