Results 71 to 80 of about 24,285 (259)

RNA Promotes Synapsin Condensates That Organize Synaptic Vesicles in Live Neurons and Enable Localized Translation in Reconstituted System

Advanced Science, Volume 13, Issue 60, 28 October 2026.
Condensates at synapses organize synaptic vesicles (SVs) and are crucial for efficient neurotransmitter release, yet how RNA contributes to this mesoscale architecture remains poorly understood. Here we uncover that RNA modulates synapsin–driven condensates.
Branislava Rankovic, Zachary M. Geisterfer, Akshita Chhabra, Vladimir M. Jovanovic, Ian Seim, Christian Hoffmann, Antonela Condric, Gerard Aguilar Pérez, Rinse de Boer, Lars T. Hofstede, Jingao Sun, Kiara Freitag, Katja Nowick, Marina Jendrach, Frank L. Heppner, Vladimir Despic, Michaela Müller‐McNicoll, Stephan Sigrist, Geert van den Bogaart, Sofiia Reshetniak, Amy S. Gladfelter, Dragomir Milovanovic   +21 more
wiley   +1 more source

Detection of antibodies against p24 or gp41 recombinant proteins and peptides in the longitudinal samples.

, 2016
The antibody titers are plotted as optical density (OD) on the y-axis. (A) Testing of antibodies against recombinant p24, gp41 and the peptides p24-p1, p24-p2, p24-p3, gp41-p1, gp41-p2 in 37 well-characterized samples from recently (white) or long-term ...
Shouyi Yu (3324669), Shuyun Deng (443916), Yue Wu (1262184), Xuqi Ren (3150255), Guifang Hu (3324672), Xiufen Li (3324666), Shixing Tang (196371)   +6 more
core   +1 more source

Broadly neutralizing HIV antibodies define a glycan-dependent epitope on the pre-fusion conformation of the gp41 protein on cleaved Envelope trimers

Immunity, 2014
SUMMARY Broadly neutralizing antibodies to HIV are much sought-after (a) to guide vaccine design, both as templates and to inform on the authenticity of vaccine candidates, (b) to assist in structural studies and (c) as potential therapeutics.
Emilia Falkowska, Khoa Le, Alejandra Ramos, K. Doores, J. Lee, C. Blattner, A. Ramírez, R. Derking, M. V. van Gils, Chi-Hui Liang, R. McBride, Benjamin von Bredow, Sachin S Shivatare, Chung-Yi Wu, P. Chan-hui, Y. Liu, T. Feizi, M. Zwick, W. Koff, M. Seaman, K. Swiderek, J. Moore, David Evans, J. Paulson, C. Wong, A. Ward, I. Grant Wilson, R. Sanders, P. Poignard, D. Burton   +29 more
semanticscholar   +1 more source

The Lord of the Rings: Cysteine bonds crosslink the tail of siphovirus

Protein Science, Volume 35, Issue 10, October 2026.
Abstract Long, non‐contractile tails composed of helical hexameric protein repeats that assemble into continuous tubular structures characterize siphoviruses. The siphovirus tail tube protein gp39 contains two cysteine residues per monomer. Cryo‐electron microscopy revealed that these cysteines are oriented toward the interface between the rings, which
Simona Povilonienė, Giedrius Sasnauskas, Giedrė Tamulaitienė, Greta Labutytė, Martynas Talaikis, Algirdas Mikšys, Aurelija Zajančkauskaitė, Lidija Truncaitė, Rolandas Meškys, Vida Časaitė   +9 more
wiley   +1 more source

HIV-1 gp41 ectodomain enhances Cryptococcus neoformans binding to human brain microvascular endothelial cells via gp41 core-induced membrane activities

, 2011
Cryptococcus neoformans causes life-threatening meningoencephalitis, particularly prevalent in AIDS patients. The interrelationship between C. neoformans and HIV-1 is intriguing, as both pathogens elicit severe neuropathological complications.
Ambrose Y. Jong, Chu-Hua Wu, Albert S. Lossinsky, Ingrid Bahner, Sheng-He Huang, Shibo Jiang   +5 more
core   +1 more source

Structural delineation of a quaternary, cleavage-dependent epitope at the gp41-gp120 interface on intact HIV-1 Env trimers

Immunity, 2014
Summary All previously characterized broadly neutralizing antibodies to the HIV-1 envelope glycoprotein (Env) target one of four major sites of vulnerability.
C. Blattner, J. Lee, Kwinten Sliepen, R. Derking, Emilia Falkowska, Alba Torrents de la Peña, A. Cupo, J. Julien, M. V. van Gils, Peter S. Lee, W. Peng, J. Paulson, P. Poignard, D. Burton, J. Moore, R. Sanders, I. Grant Wilson, A. Ward   +17 more
semanticscholar   +1 more source

Targeting Human Immunodeficiency Virus Integrase Beyond the Active Site: The Discovery and Development of Allosteric Integrase Inhibitors

ChemMedChem, Volume 21, Issue 16, 27 August 2026.
Human immunodeficiency virus (HIV) allosteric integrase inhibitors (ALLINIs) offer a vital alternative to standard therapies by targeting noncatalytic sites. By inducing aberrant integrase multimerization, they disrupt viral maturation. This review explores their medicinal chemistry evolution, detailing structural insights, structure–activity ...
Francesco Saccoliti, Elisa Patacchini, Emanuele Cara, Laura Zarbo, Antonella Messore, Aurora Albano, Giuseppe Ruggieri, Valentina Noemi Madia, Luigi Scipione, Roberta Costi, Roberto Di Santo   +10 more
wiley   +1 more source

Altering Expression Levels of Human Immunodeficiency Virus Type 1 gp120-gp41 Affects Efficiency but Not Kinetics of Cell-Cell Fusion

, 2002
Human immunodeficiency virus (HIV) entry into a host cell requires the fusion of virus and cellular membranes that is driven by interaction of the viral envelope glycoproteins gp120 and gp41 (gp120/gp41) with CD4 and a coreceptor, typically either CXCR4 ...
Daria J. Hazuda, Janet E. Lineberger, Michael D. Miller, Renee Danzeisen, Adam J. Simon   +4 more
core   +1 more source

Development of Protein- and Peptide-Based HIV Entry Inhibitors Targeting gp120 or gp41

Viruses, 2019
Application of highly active antiretroviral drugs (ARDs) effectively reduces morbidity and mortality in HIV-infected individuals. However, the emergence of multiple drug-resistant strains has led to the increased failure of ARDs, thus calling for the ...
Jing Pu, Qian Wang, Wei Xu, Lu Lu, Shibo Jiang   +4 more
doaj   +1 more source

The Glu143 Residue Might Play a Significant Role in T20 Peptide Binding to HIV-1 Receptor gp41: An In Silico Study

Molecules, 2022
Despite the enormous efforts made to develop other fusion inhibitors for HIV, the enfuvirtide (known as T20) peptide is the only approved HIV-1 inhibitory drug so far.
Ahmed L. Alaofi
doaj   +1 more source