Results 71 to 80 of about 13,523 (178)

Combination of anti-retroviral drugs and radioimmunotherapy specifically kills infected cells from HIV infected individuals

Frontiers in Medicine, 2016
Eliminating virally infected cells is an essential component of any HIV eradication strategy. Radioimmunotherapy (RIT), a clinically established method for killing cells using radiolabeled antibodies, was recently applied to target HIV-1 gp41 antigen ...
Dina Tsukrov, Alicia McFarren, Alfred Morgenstern, Frank Bruchertseifer, Eugene Dolce, Miroslaw K Gorny, Susan Zolla-Pazner, Joan W Berman, Ellie Schoenbaum, Barry S Zingman, Arturo Casadevall, Ekaterina Dadachova   +11 more
doaj   +1 more source

Gp41-targeted antibodies restore infectivity of a fusion-deficient HIV-1 envelope glycoprotein.

PLoS Pathogens, 2020
The HIV-1 envelope glycoprotein (Env) mediates viral entry via conformational changes associated with binding the cell surface receptor (CD4) and coreceptor (CCR5/CXCR4), resulting in subsequent fusion of the viral and cellular membranes. While the gp120
Vinita R Joshi, Ruchi M Newman, Melissa L Pack, Karen A Power, James B Munro, Ken Okawa, Navid Madani, Joseph G Sodroski, Aaron G Schmidt, Todd M Allen   +9 more
doaj   +1 more source

Fragment Templates in Molecularly Imprinted Polymer Synthesis: Design Strategies, Critical Factors, and Analytical Applications

Advances in Materials Science and Engineering, Volume 2026, Issue 1, 2026.
The utilization of fragment templates in molecular imprinting polymer (MIP) synthesis attracts significant interest in its potential to create polymers with high specificity in recognizing target molecules. The primary advantage of fragment templates lies in their capacity to extract target molecules by focusing on specific components, thus forming ...
Ezra Calista Hutapea, Diva Dhaifina Mazaya Priana, Driyanti Rahayu, Aliya Nur Hasanah, Mohammad Rezwan Habib   +4 more
wiley   +1 more source

Enhanced potency of bivalent small molecule gp41 inhibitors

Bioorganic & Medicinal Chemistry, 2017
Low molecular weight peptidomimetic inhibitors with hydrophobic pocket binding properties and moderate fusion inhibitory activity against HIV-1 gp41-mediated cell fusion were elaborated by increasing the available surface area for interacting with the heptad repeat-1 (HR1) coiled coil on gp41.
Vladimir, Sofiyev, Hardeep, Kaur, Beth A, Snyder, Priscilla A, Hogan, Roger G, Ptak, Peter, Hwang, Miriam, Gochin   +6 more
openaire   +3 more sources

Induction of HIV‐Specific T Cell Responses Using αDC1 Pulsed With Conserved HIV‐1 Peptides

Journal of Immunology Research, Volume 2026, Issue 1, 2026.
Despite the effectiveness of antiretroviral therapy (ART) in suppressing HIV‐1 replication and reducing morbidity, viral eradication remains unachievable due to the persistence of latent reservoirs, particularly within memory CD4+ T cells. Dendritic cell (DC)‐based immunotherapeutic approaches have emerged as potential strategies to enhance antigen ...
Laís Teodoro Da Silva, Marina Mazzilli Ortega, Silvia de Jesus Mota, Guilherme Castellani, Dennyson Leandro M. Fonseca, Larissa Danielle Bahls Pinto, Gabriela Justamante Handel Schmitz, Isabela Leite, Theo Leite, Mariana Amelia Monteiro, Sandra Marcia Muxel, Robbie B. Mailliard, Alberto José da Silva Duarte, Telma Miyuki Oshiro, Poorani Gurumallesh Prabu   +14 more
wiley   +1 more source

Nanostructured Electrochemical Sensors for Rapid HIV Detection

Journal of Sensors, Volume 2026, Issue 1, 2026.
Many significant and transmissible diseases, including human immunodeficiency virus (HIV)/acquired immune deficiency syndrome (AIDS), COVID‐19, hepatitis, and influenza, are caused by viruses. The rapid replication ability of these viruses is the primary reason for their widespread transmission, resulting in consequences such as loss of life at both ...
Dharmesh Kumar, Sudheesh K. Shukla, Penny P. Govender, Deepali   +3 more
wiley   +1 more source

Meeting Review: 2018 International Workshop on Structure and Function of the Lentiviral gp41 Cytoplasmic Tail

Viruses, 2018
Recent developments in defining the role of the lentiviral envelope glycoprotein (Env) cytoplasmic tail (CT) in Env trafficking and incorporation into virus particles have advanced our understanding of viral replication and transmission.
Melissa V. Fernandez, Eric O. Freed
doaj   +1 more source

Enhanced One‐Pot Dual‐CRISPR‐Based Assay Lyophilized on a 3D‐Printed Disc for Field‐Deployable Multiplex Bacteria Detection

Advanced Science, Volume 12, Issue 45, December 4, 2025.
An enhanced one‐pot, helicase‐assisted recombinase polymerase amplification (hRPA)‐combined, dual‐CRISPR/uAsCas12a assay is developed and lyophilized on a 3D‐printed microfluidic disc to achieve field‐deployable multiplex bacteria detection. Abstract One‐pot CRISPR‐based detection combining recombinase polymerase amplification (RPA) enables rapid and ...
Yuqing Shen, Bo Lu, Biao Ma, Xiong Ding
wiley   +1 more source

Human gut microbiota is associated with HIV-reactive immunoglobulin at baseline and following HIV vaccination.

PLoS ONE, 2019
Antibodies that recognize commensal microbial antigens may be cross reactive with a part of the human immunodeficiency virus (HIV) envelope glycoprotein gp41. To improve understanding of the role of the microbiota in modulating the immune response to HIV
Jacob A Cram, Andrew J Fiore-Gartland, Sujatha Srinivasan, Shelly Karuna, Giuseppe Pantaleo, Georgia D Tomaras, David N Fredricks, James G Kublin   +7 more
doaj   +1 more source

Host and Viral Factors in HIV-Mediated Bystander Apoptosis

Viruses, 2017
Human immunodeficiency virus (HIV) infections lead to a progressive loss of CD4 T cells primarily via the process of apoptosis. With a limited number of infected cells and vastly disproportionate apoptosis in HIV infected patients, it is believed that ...
Himanshu Garg, Anjali Joshi
doaj   +1 more source