Results 71 to 80 of about 13,547 (178)
Computer-Aided Approaches for Targeting HIVgp41
Biology, 2012 Virus-cell fusion is the primary means by which the human immunodeficiency virus-1 (HIV) delivers its genetic material into the human T-cell host. Fusion is mediated in large part by the viral glycoprotein 41 (gp41) which advances through four distinct ...
William J. Allen, Robert C. Rizzo
doaj +1 more source
HIV-1 Induced Bystander Apoptosis
Viruses, 2012 Apoptosis of uninfected bystander cells is a key element of HIV pathogenesis and believed to be the driving force behind the selective depletion of CD4+ T cells leading to immunodeficiency.
Anjali Joshi +2 more
doaj +1 more source
Journal of Nanobiotechnology, 2011 Background HIV/AIDS pandemic is a worldwide public health issue. There is a need for new approaches to develop new antiviral compounds or other therapeutic strategies to limit viral transmission.
Garza Treviño Elsa N +3 more
doaj +1 more source
Emerging Microbes and Infections, 2017 Protein- or peptide-based viral inactivators are being developed as novel antiviral drugs with improved efficacy, pharmacokinetics and toxicity profiles because they actively inactivate cell-free human immunodeficiency virus type 1 (HIV-1) virions before
Qianqian Qi +6 more
doaj +1 more source
ADS-J21 is a novel HIV-1 entry inhibitor targeting gp41
Current Research in Microbial SciencesHIV-1 envelope glycoprotein gp41 mediates fusion between HIV-1 and host cell membranes, making inhibitors of gp41 attractive anti-HIV drugs. We previously reported an efficient HIV-1 fusion inhibitor, ADS-J1, with a Y-shaped structure.
Ruiying Liang +12 more
doaj +1 more source