Results 81 to 90 of about 13,523 (178)
Gp41, a superfamily SF2 helicase from bacteriophage BFK20
Virus Research, 2018 Gp41 is one of two helicases encoded by the genome of bacteriophage BFK20. The gp41 sequence contains conserved motifs from the SF2 family of helicases. We prepared and studied three recombinant proteins: gp41HN, a wild type-like protein with an N-terminal His-Tag; gp41HC, with an S2A mutation and a C-terminal His-Tag; and gp41dC, a mutant protein with
Nora, Halgasova +5 more
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Computer-Aided Approaches for Targeting HIVgp41
Biology, 2012 Virus-cell fusion is the primary means by which the human immunodeficiency virus-1 (HIV) delivers its genetic material into the human T-cell host. Fusion is mediated in large part by the viral glycoprotein 41 (gp41) which advances through four distinct ...
William J. Allen, Robert C. Rizzo
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HIV-1 Induced Bystander Apoptosis
Viruses, 2012 Apoptosis of uninfected bystander cells is a key element of HIV pathogenesis and believed to be the driving force behind the selective depletion of CD4+ T cells leading to immunodeficiency.
Anjali Joshi +2 more
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Journal of Nanobiotechnology, 2011 Background HIV/AIDS pandemic is a worldwide public health issue. There is a need for new approaches to develop new antiviral compounds or other therapeutic strategies to limit viral transmission.
Garza Treviño Elsa N +3 more
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Emerging Microbes and Infections, 2017 Protein- or peptide-based viral inactivators are being developed as novel antiviral drugs with improved efficacy, pharmacokinetics and toxicity profiles because they actively inactivate cell-free human immunodeficiency virus type 1 (HIV-1) virions before
Qianqian Qi +6 more
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Identification of the HIV‐1 gp41 core‐binding motif – HXXNPF
FEBS Letters, 2006 The HIV‐1 gp41 core, a six‐helix bundle formed between the N‐ and C‐terminal heptad repeats, plays a critical role in fusion between the viral and target cell membranes. Using N36(L8)C34 as a model of the gp41 core to screen phage display peptide libraries, we identified a common motif, HXXNPF (X is any of the 20 natural amino acid residues).
Huang, Jing-He +4 more
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Mimicking the pre-hairpin intermediate of gp41
, 2008 A novel screening platform for potential retroviral fusion inhibitors on the basis of fully functional membrane‐anchored coiled coil lipopeptide receptors has been established. The work comprises the scrutiny of lateral organization of functional lipids in phase separated bilayers and an in‐depth investigation of the biophysical properties of ...
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