Results 81 to 90 of about 24,285 (259)

Chemical Optimization of Temporin A–L Peptides: From Native Isoforms to Enhanced Antimicrobial Analogs

ChemMedChem, Volume 21, Issue 15, 14 August 2026.
Temporins, among antimicrobial peptides, are short frog‐derived molecules with potent antibacterial activity. This review highlights chemical optimization strategies applied to temporins A–L, showing how sequence tuning modulates structure, stability, and selectivity, enabling improved activity against resistant pathogens.
Ida Boccino, Paolo Grieco, Francesco Merlino   +2 more
wiley   +1 more source

Recombinant gp41 expressed on murine tumour cells inhibits the effector functions of antigen-primed CD8⁺ T cells.

, 2017
a) Analysis of gp41 expression and secretion in stably selected cTRAMP cells. Lysates of empty vector (cTRAMP CL) or gp41 plasmid transfected cTRAMP cells (cTRAMP-gp41 CL) or supernatant of cTRAMP-gp41 cells incubated with NiNTA beads were separated by ...
Daniel Stern (213946), Werner Luttmann (3830152), Melissa Lehmann (3830143), Michael Mühle (3830149), Kerstin Hoffmann (149621), Joachim Denner (278115), Tobias Kroniger (3830146)   +6 more
core   +1 more source

A Comprehensive Analysis of the T and B Lymphocytes Repertoire Shaped by HIV Vaccines

Frontiers in Immunology, 2018
The exploitation of various human immunodeficiency virus type-1 (HIV-1) vaccines has posed great challenges for the researchers in precisely evaluating the vaccine-induced immune responses, however, the understanding of vaccination response suffers from ...
Longlong Wang, Longlong Wang, Longlong Wang, Wei Zhang, Wei Zhang, Liya Lin, Liya Lin, Xiao Li, Xiao Li, Nitin K. Saksena, Nitin K. Saksena, Jinghua Wu, Jinghua Wu, Shiyu Wang, Shiyu Wang, Shiyu Wang, Joseph G. Joyce, Xiuqing Zhang, Xiuqing Zhang, Huanming Yang, Huanming Yang, Jian Wang, Jian Wang, I-Ming Wang, Xiao Liu, Xiao Liu   +25 more
doaj   +1 more source

Targeting a Conserved Lysine in the Hydrophobic Pocket of HIV-1 gp41 Improves Small Molecule Antiviral Activity

Viruses, 2022
Human Immunodeficiency virus (HIV-1) fusion is mediated by glycoprotein-41, a protein that has not been widely exploited as a drug target. Small molecules directed at the gp41 ectodomain have proved to be poorly drug-like, having moderate efficacy, high ...
Li He, Guangyan Zhou, Vladimir Sofiyev, Eddie Garcia, Newton Nguyen, Kathy H. Li, Miriam Gochin   +6 more
doaj   +1 more source

Antibodies to a conformational epitope on gp41 neutralize HIV-1 by destabilizing the Env spike

Nature Communications, 2015
The recent identification of three broadly neutralizing antibodies (bnAbs) against gp120–gp41 interface epitopes has expanded the targetable surface on the HIV-1 envelope glycoprotein (Env) trimer.
J. Lee, D. Leaman, A. Kim, A. T. Torrents de la Pena, Kwinten Sliepen, A. Yasmeen, R. Derking, Alejandra Ramos, S. D. de Taeye, G. Ozorowski, F. Klein, D. Burton, M. Nussenzweig, P. Poignard, J. Moore, P. Klasse, R. Sanders, M. Zwick, I. Grant Wilson, A. Ward   +19 more
semanticscholar   +1 more source

ZDHHC18‐Mediated Palmitoylation of ORF3a Promotes SARS‐CoV‐2 Pathogenesis by Antagonizing TRIM16‐Mediated Ubiquitination and Proteasomal Degradation

Advanced Science, Volume 13, Issue 43, 3 August 2026.
Palmitoylation by ZDHHC18 blocks ORF3a K27‐linked ubiquitination mediated by TRIM16, thereby preventing its proteasomal degradation and strengthening viral pathogenesis. Targeting palmitoylation through a pharmacological inhibitor (2‐BP), a competitive inhibitory peptide (OPIP), or adenovirus‐mediated knockdown of ZDHHC18 expression presents a ...
Sidi Yang, Kun Li, Lihong Liu, Linsen Zeng, Qifeng Deng, Jiacheng Huang, Xiaoran Dong, Xin Wang, Jianwei Liang, Hongchao Liu, Hong Peng, Yuxin Lin, Xiaolu Xie, Yuzhen Ye, Tiefeng Xu, Zhaohuan Wang, Chun‐Mei Li, Deyin Guo   +17 more
wiley   +1 more source

Rapid and simple purification of human immunodeficiency virus 1 epitope gp41

, 1993
In order to develop a reliable and inexpensive serodiagnostic method, part of the transmembrane glycoprotein gene of HIV-1, gp41', (HIV-env 548-646) was cloned into an expression vector, pCT10 with a sequence encoding a hydroxylamine cleavage site and ...
Young-Hae Chong, Seo Hee Cho, Won-Hee Jang, Sang Uk Nham, Mi Jin Sohn, Young Ik Lee   +5 more
core   +1 more source

TLR10 Senses HIV-1 Proteins and Significantly Enhances HIV-1 Infection

Frontiers in Immunology, 2019
Toll-like receptors (TLRs) play a crucial role in innate immunity and provide a first line of host defense against invading pathogens. Of the identified human TLRs, TLR10 remains an orphan receptor whose ligands and functions are poorly understood.
Bethany M. Henrick, Bethany M. Henrick, Xiao-Dan Yao, Muhammad Atif Zahoor, Alash'le Abimiku, Sophia Osawe, Kenneth L. Rosenthal   +6 more
doaj   +1 more source

Detection of antibodies against the recombinant p24 or gp41 and peptides in recently and long-term HIV-1-infected individuals.

, 2016
ELISA was used to detect antibodies against recombinant p24 (A), peptide p24-p1 (B), p24-p2 (C), p24-p3 (D), recombinant gp41 (E), peptide gp41-p1 (F), gp41-p2 (G) and gp41-p3 (H), respectively in the samples of HIV-1-infected subjects collected from a ...
Shouyi Yu (3324669), Shuyun Deng (443916), Yue Wu (1262184), Xuqi Ren (3150255), Guifang Hu (3324672), Xiufen Li (3324666), Shixing Tang (196371)   +6 more
core   +1 more source

Development of Small-molecule HIV Entry Inhibitors Specifically Targeting gp120 or gp41

Current Topics in Medicinal Chemistry, 2015
Human immunodeficiency virus type 1 (HIV-1) envelope (Env) glycoprotein surface subunit gp120 and transmembrane subunit gp41 play important roles in HIV-1 entry, thus serving as key targets for the development of HIV-1 entry inhibitors.
Lu Lu, Fei Yu, Li-Feng Cai, A. K. Debnath, Shi-Bo Jiang   +4 more
semanticscholar   +1 more source