Results 91 to 100 of about 24,285 (259)

Efficient Assembly of Coxsackievirus A16 Virus‐Like Particles in Insect Cells via VP4‐Deficient P1 Expression

Entomological Research, Volume 56, Issue 8, August 2026.
ABSTRACT Coxsackievirus A16 (CVA16) is a major causative agent of hand, foot, and mouth disease (HFMD), yet efficient virus‐like particle (VLP)–based vaccine development remains challenging due to enteroviral structural complexity and the cytotoxicity of the 3CD protease required for polyprotein processing.
Hyun‐Soo Kim, Hyuk‐Jin Moon, Ra‐Mi Woo, Jae‐Bang Choi, Beom‐Ku Han, Soo Dong Woo   +5 more
wiley   +1 more source

The development of HIV vaccines targeting gp41 membrane-proximal external region (MPER): challenges and prospects

Protein & Cell, 2018
A human immunodeficiency virus type-1 (HIV-1) vaccine which is able to effectively prevent infection would be the most powerful method of extinguishing pandemic of the acquired immunodeficiency syndrome (AIDS).
Huan Liu, Xiaojie Su, Lulu Si, Lu Lu, Shibo Jiang   +4 more
doaj   +1 more source

Induction of antibodies in rhesus macaques that recognize a fusion-intermediate conformation of HIV-1 gp41. [PDF]

PLoS ONE, 2011
A component to the problem of inducing broad neutralizing HIV-1 gp41 membrane proximal external region (MPER) antibodies is the need to focus the antibody response to the transiently exposed MPER pre-hairpin intermediate neutralization epitope.
S Moses Dennison, Laura L Sutherland, Frederick H Jaeger, Kara M Anasti, Robert Parks, Shelley Stewart, Cindy Bowman, Shi-Mao Xia, Ruijun Zhang, Xiaoying Shen, Richard M Scearce, Gilad Ofek, Yongping Yang, Peter D Kwong, Sampa Santra, Hua-Xin Liao, Georgia Tomaras, Norman L Letvin, Bing Chen, S Munir Alam, Barton F Haynes   +20 more
doaj   +1 more source

Expression, purification and crystallization of CTB-MPR, a candidate mucosal vaccine component against HIV-1

IUCrJ, 2014
CTB-MPR is a fusion protein between the B subunit of cholera toxin (CTB) and the membrane-proximal region of gp41 (MPR), the transmembrane envelope protein of Human immunodeficiency virus 1 (HIV-1), and has previously been shown to induce the production ...
Ho-Hsien Lee, Irene Cherni, HongQi Yu, Raimund Fromme, Jeffrey D. Doran, Ingo Grotjohann, Michele Mittman, Shibom Basu, Arpan Deb, Katerina Dörner, Andrew Aquila, Anton Barty, Sébastien Boutet, Henry N. Chapman, R. Bruce Doak, Mark S. Hunter, Daniel James, Richard A. Kirian, Christopher Kupitz, Robert M. Lawrence, Haiguang Liu, Karol Nass, Ilme Schlichting, Kevin E. Schmidt, M. Marvin Seibert, Robert L. Shoeman, John C. H. Spence, Francesco Stellato, Uwe Weierstall, Garth J. Williams, Chunhong Yoon, Dingjie Wang, Nadia A. Zatsepin, Brenda G. Hogue, Nobuyuki Matoba, Petra Fromme, Tsafrir S. Mor   +36 more
doaj   +1 more source

Effects of the I559P gp41 Change on the Conformation and Function of the Human Immunodeficiency Virus (HIV-1) Membrane Envelope Glycoprotein Trimer

PLoS ONE, 2015
The mature human immunodeficiency virus (HIV-1) envelope glycoprotein (Env) trimer is produced by proteolytic cleavage of a precursor and consists of three gp120 exterior and three gp41 transmembrane subunits.
Nirmin Alsahafi, Olfa Débbeche, J. Sodroski, A. Finzi   +3 more
semanticscholar   +1 more source

AlphaFold2‐Guided Cyclic Peptide Stabilizer Design to Target Protein–Protein Interactions

Proteins: Structure, Function, and Bioinformatics, Volume 94, Issue 7, Page 1356-1370, July 2026.
ABSTRACT The control and modulation of protein–protein interactions (PPIs) is of central importance for the majority of biological processes and most biomedical applications. Stabilization of PPIs, besides inhibition, is of growing pharmaceutical interest.
Niklas Halbwedl, Martin Zacharias
wiley   +1 more source

Gp41 TMD co-localizes with CD3 within the TCR complex.

, 2013
Gp41 TMD-NBD and AMP-NBD were used to study peptide binding to the membranes of resting and activated T cells in combination with Sy5-labeled antibodies to CD3. The T cells had been activated by incubation with APC and the MOG 35–55 peptide.
Yechiel Shai (137126), Niv Antonovsky (362059), Irun R. Cohen (110065), Tomer Cohen (362057), Shmuel Jaffe Cohen (362058)   +4 more
core   +1 more source

Adding an Artificial Tail—Anchor to a Peptide-Based HIV-1 Fusion Inhibitor for Improvement of Its Potency and Resistance Profile

Molecules, 2017
Peptides derived from the C-terminal heptad repeat (CHR) of human immunodeficiency virus type 1 (HIV-1) envelope protein transmembrane subunit gp41, such as T20 (enfuvirtide), can bind to the N-terminal heptad repeat (NHR) of gp41 and block six-helix ...
Shan Su, Zhenxuan Ma, Chen Hua, Weihua Li, Lu Lu, Shibo Jiang   +5 more
doaj   +1 more source

Bacterial Extracellular Vesicles (BEVs) Derived from Chryseobacterium Inhibit Dengue Virus Infection by Disrupting Its Structural Integrity

Journal of Extracellular Vesicles, Volume 15, Issue 6, June 2026.
This study elucidates a novel antiviral mechanism of bacterial BEVs, which are shown to inactivate viruses by triggering membrane fusion, subsequent lysis and causing structural collapse. This direct virucidal action presents a promising broad‐spectrum strategy against diverse enveloped viruses.
Yaqi Gao, Lijian Zhang, Tianci Zhang, Qiufeng Yao, Ruifang Gao, Yue Wang, Yunpeng Zhao, Tingting Zhou, Jikuai Chen, Xing Zhang, Hao Ren, Yongzhe Zhu, Ping Zhao, Zhongtian Qi, Li Luo, Zhaoling Qin   +15 more
wiley   +1 more source

Corrigendum: Fertilization competence of the egg-coating envelope is regulated by direct interaction of dicalcin and gp41, the Xenopus laevis ZP3

Scientific Reports, 2015
Fertilization begins with species-restricted interaction of sperm and the egg-coating envelope, which includes a three-dimensional meshwork of filaments composed of glycoproteins (called ZP proteins). Growing evidence has unveiled the molecular nature of
N. Miwa, Motoyuki Ogawa, Mayu Hanaue, K. Takamatsu   +3 more
semanticscholar   +1 more source