Results 111 to 120 of about 24,285 (259)

Role of Hydrophobic Residues in the Central Ectodomain of gp41 in Maintaining the Association Between Human Immunodeficiency Virus Type 1 Envelope Glycoprotein Subunits gp120 and gp41 [PDF]

, 2004
The interaction between the gp120 and gp41 subunits of the human immunodeficiency virus envelope glycoprotein serves to stabilize the virion form of the complex and to transmit receptor-induced conformational changes in gp120 to trigger the membrane ...
York, Joanne, Nunberg, Jack H.
core  

Competitive antigen panning for selection of HIV-1 neutralizing human monoclonal antibodies specific for gp41.

, 2009
HIV envelope glycoprotein (Env) is composed of two non-covalently associated subunits: gp120 and gp41. Panning of phage-displayed antibody libraries against gp140 (covalently linked gp120 and the extracellular portion of gp41) has resulted mostly in ...
Zhang, MY, Dimitrov, DS, Zhang, M
core   +1 more source

Human gut microbiota is associated with HIV-reactive immunoglobulin at baseline and following HIV vaccination.

PLoS ONE, 2019
Antibodies that recognize commensal microbial antigens may be cross reactive with a part of the human immunodeficiency virus (HIV) envelope glycoprotein gp41. To improve understanding of the role of the microbiota in modulating the immune response to HIV
Jacob A Cram, Andrew J Fiore-Gartland, Sujatha Srinivasan, Shelly Karuna, Giuseppe Pantaleo, Georgia D Tomaras, David N Fredricks, James G Kublin   +7 more
doaj   +1 more source

Anti-HIV-1 activity of cellulose acetate phthalate: Synergy with soluble CD4 and induction of "dead-end" gp41 six-helix bundles

BMC Infectious Diseases, 2002
Background Cellulose acetate phthalate (CAP), a promising candidate microbicide for prevention of sexual transmission of the human immunodeficiency virus type 1 (HIV-1) and other sexually transmitted disease (STD) pathogens, was shown to inactivate HIV-1
Li Yun-Yao, Jiang Shibo, Strick Nathan, Neurath A Robert, Debnath Asim K   +4 more
doaj   +1 more source

Nonneutralizing HIV-1 gp41 Envelope Cluster II Human Monoclonal Antibodies Show Polyreactivity for Binding to Phospholipids and Protein Autoantigens

, 2011
HIV-1 gp41 envelope antibodies, which are frequently induced in HIV-1-infected individuals, are predominantly nonneutralizing. The rare and difficult-to-induce neutralizing antibodies (2F5 and 4E10) that target gp41 membrane-proximal epitopes (MPER) are ...
Miroslaw K. Gorny, Kara Anasti, Shi-Mao Xia, Richard M. Scearce, S. Munir Alam, S. Moses Dennison, Laura Sutherland, Susan Zolla-Pazner, Robert Parks, Hua-Xin Liao, Barton F. Haynes   +10 more
core   +1 more source

HIV-1 Envelope gp41 Antibodies Can Originate from Terminal Ileum B Cells that Share Cross-Reactivity with Commensal Bacteria

Cell Host and Microbe, 2014
SUMMARY Monoclonal antibodies derived from blood plasma cells of acute HIV-1-infected individuals are predominantly targeted to the HIV Env gp41 and cross-reactive with commensal bacteria.
A. Trama, M. Moody, S. Alam, F. Jaeger, Bradley Lockwood, Robert Parks, K. Lloyd, C. Stolarchuk, R. Scearce, A. Foulger, D. Marshall, J. Whitesides, Thomas L. Jeffries, K. Wiehe, L. Morris, B. Lambson, K. Soderberg, K. Hwang, G. Tomaras, N. Vandergrift, K. Jackson, Krishna M. Roskin, S. Boyd, T. Kepler, H. Liao, B. Haynes   +25 more
semanticscholar   +1 more source

Antibody to gp41 MPER Alters Functional Properties of HIV-1 Env without Complete Neutralization

PLoS Pathogens, 2014
Human antibody 10E8 targets the conserved membrane proximal external region (MPER) of envelope glycoprotein (Env) subunit gp41 and neutralizes HIV-1 with exceptional potency. Remarkably, HIV-1 containing mutations that reportedly knockout 10E8 binding to
A. Kim, D. Leaman, M. Zwick
semanticscholar   +1 more source

Six-helix bundle completion in the distal C-terminal heptad repeat region of gp41 is required for efficient human immunodeficiency virus type 1 infection

Retrovirology, 2018
Background The native pre-fusion structure of gp120/gp41 complex of human immunodeficiency virus type 1 was recently revealed. In the model, the helices of gp41 (α6, α7, α8, and α9) form a four-helix collar underneath trimeric gp120.
Dehua Liu, Hongyun Wang, Mizuki Yamamoto, Jiping Song, Rui Zhang, Qingling Du, Yasushi Kawaguchi, Jun-ichiro Inoue, Zene Matsuda   +8 more
doaj   +1 more source

SPR analysis of monoclonal antibody binding to gp41 oligomers.

, 2015
SPR analysis of monoclonal antibody binding to gp41 oligomers.
Indresh K. Srivastava (120023), Carol D. Weiss (218374), Zohar Biron-Sorek (756830), Min Zhuang (218356), Prasad Vennakalanti (756829), Susan W. Barnett (120170), Russell Vassell (218358), Celia C. LaBranche (172138), David C. Montefiori (108747), Antu K. Dey (172141), Wei Wang (17594), Yong He (115255), Yide Sun (334156)   +12 more
core   +1 more source

Identification of membrane-active regions of the HIV-1 envelope glycoprotein gp41 using a 15-mer gp41-peptide scan

Biochimica et Biophysica Acta (BBA) - Biomembranes, 2004
The identification of membrane-active regions of the ectodomain of the HIV-1 envelope glycoprotein gp41 has been made by determining the effect on membrane integrity of a 15-mer gp41-derived peptide library. By monitoring the effect of this peptide library on membrane leakage, we have identified three regions on the gp41 ectodomain with membrane ...
Moreno, Miguel R., Pascual, Roberto, Villalaín, José   +2 more
openaire   +2 more sources