Antigenic and immunosuppressive properties of a trimeric recombinant transmembrane envelope protein gp41 of HIV-1. [PDF]
PLoS ONE, 2017 The transmembrane envelope (TM) protein gp41 of the human immunodeficiency virus-1 (HIV-1) plays an important role during virus infection inducing the fusion of the viral and cellular membranes.
Michael Mühle +6 more
doaj +7 more sources
HIV-1 Envelope Protein gp41: An NMR Study of Dodecyl Phosphocholine Embedded gp41 Reveals a Dynamic Prefusion Intermediate Conformation [PDF]
Structure, 2014 Human immunodeficiency viral (HIV-1) fusion is mediated by the viral envelope gp120/gp41 complex (ENVelope glycoprotein). After gp120 shedding, gp41 is exposed and elicits membrane fusion via a cascade of conformational changes. In contrast to prefusion and postfusion conformation, little is known about any intermediate conformation.
Lakomek, N. +3 more
openaire +5 more sources
Insights from the interfaces of HIV-1 envelope (ENV) trimer viral protein GP160 (GP120-GP41)
International Journal of Research in Pharmaceutical Sciences, 2021 The Human Immunodeficiency Virus (HIV-1) type 1 viral protein is a life threatening virus causing HIV/AIDS in infected humans. The HIV-1 envelope (ENV) trimer glycoprotein GP160 (GP120-GP41) is gaining attention in recent years as a potential vaccine ...
Christina Nilofer, Arumugam Mohanapriya
doaj +2 more sources
Conversion of an Immunogenic Human Immunodeficiency Virus (HIV) Envelope Synthetic Peptide to a Tolerogen in Chimpanzees by the Fusogenic Domain of HIV gp41 Envelope Protein. [PDF]
Journal of Experimental Medicine, 1993 The fusogenic (F) domain of human immunodeficiency virus (HIV) gp41 envelope (env) protein has sequence similarities to many virus and mediates the fusion of HIV-infected cells. During a survey of the immunogenicity of HIV env peptides in chimpanzees, we have observed that HIV peptide immunogenicity was dramatically altered by the NH2-terminal ...
Barton F Haynes, A J Langlois, C McDanal
exaly +3 more sources
Modulation of Cytokine Production by the Transmembrane Envelope Protein gp41 of HIV-1 [PDF]
Retrovirology, 2005 Elevated IL-6, IL-10, IL-8, gro-alpha and TNF-alpha and decreased IL-2 values have been regularly observed in HIV infected individuals. To study the influence of the transmembrane envelope protein gp41 of HIV-1 on the cytokine production by human blood donor PBMCs, additional cytokine arrays (RayBiotech) that measured the release of about 100 cytokines,
Behrendt Rayk +2 more
doaj +3 more sources
The Polar Region of the HIV-1 Envelope Protein Determines Viral Fusion and Infectivity by Stabilizing the gp120-gp41 Association. [PDF]
Journal of Virology, 2019 Although extensive studies of the transmembrane unit (gp41) of HIV-1 Env have led to a fusion inhibitor clinically used to block viral entry, the functions of different domains of gp41 in HIV-1 fusion and infectivity are not fully elucidated. The polar region (PR) of gp41 has been proposed to participate in HIV-1 membrane fusion in biochemical analyses,
Yong Xiong, Nathan M. Sherer, Jingyou Yu
exaly +3 more sources
Induction of antibodies in rhesus macaques that recognize a fusion-intermediate conformation of HIV-1 gp41. [PDF]
PLoS ONE, 2011 A component to the problem of inducing broad neutralizing HIV-1 gp41 membrane proximal external region (MPER) antibodies is the need to focus the antibody response to the transiently exposed MPER pre-hairpin intermediate neutralization epitope.
S Moses Dennison +20 more
doaj +2 more sources
Biochemistry and Biophysics of HIV-1 gp41 - Membrane Interactions and Implications for HIV-1 Envelope Protein Mediated Viral-Cell Fusion and Fusion Inhibitor Design [PDF]
Current Topics in Medicinal Chemistry, 2011 Human immunodeficiency virus type 1 (HIV-1), the pathogen of acquired immunodeficiency syndrome (AIDS), causes ~2 millions death every year and still defies an effective vaccine. HIV-1 infects host cells through envelope protein - mediated virus-cell fusion.
Miriam Gochin, Keliang Liu, Lifeng Cai
exaly +3 more sources
Virology, 2008 Human immunodeficiency virus type 1 (HIV-1) transmembrane glycoprotein gp41 is targeted by broadly-reactive neutralizing antibodies 2F5 and 4E10, making it an attractive target for vaccine development. To better assess immunogenic properties of gp41, we generated five soluble glutathione S-transferase fusion proteins encompassing C-terminal 30, 64, 100,
Adam Penn-Nicholson +2 more
exaly +3 more sources
IGHV1-69 B cell chronic lymphocytic leukemia antibodies cross-react with HIV-1 and hepatitis C virus antigens as well as intestinal commensal bacteria. [PDF]
PLoS ONE, 2014 B-cell chronic lymphocytic leukemia (B-CLL) patients expressing unmutated immunoglobulin heavy variable regions (IGHVs) use the IGHV1-69 B cell receptor (BCR) in 25% of cases.
Kwan-Ki Hwang +21 more
doaj +1 more source