Results 1 to 10 of about 9,575 (175)

Antigenic and immunosuppressive properties of a trimeric recombinant transmembrane envelope protein gp41 of HIV-1. [PDF]

PLoS ONE, 2017
The transmembrane envelope (TM) protein gp41 of the human immunodeficiency virus-1 (HIV-1) plays an important role during virus infection inducing the fusion of the viral and cellular membranes.
Michael Mühle, Melissa Lehmann, Kerstin Hoffmann, Daniel Stern, Tobias Kroniger, Werner Luttmann, Joachim Denner   +6 more
doaj   +5 more sources

Investigating the role of a conserved hydrophobic pocket of gp41 in the anti-HIV activity of fusion inhibitors. [PDF]

Protein Sci
Abstract Membrane fusion between HIV and host cells requires interaction between the N‐terminal and C‐terminal repeat regions (NHR and CHR) of the gp41 envelope subunit. A deep hydrophobic pocket (HP) on the surface of NHR is considered crucial in this interaction.
Polo-Megías D, Cano-Muñoz M, Sánchez-Martínez L, Lestani S, Moog C, Decoville T, Salinas-García MC, Gavira JA, Cámara-Artigas A, Conejero-Lara F.   +9 more
europepmc   +2 more sources

Conversion of an immunogenic human immunodeficiency virus (HIV) envelope synthetic peptide to a tolerogen in chimpanzees by the fusogenic domain of HIV gp41 envelope protein. [PDF]

Journal of Experimental Medicine, 1993
The fusogenic (F) domain of human immunodeficiency virus (HIV) gp41 envelope (env) protein has sequence similarities to many virus and mediates the fusion of HIV-infected cells. During a survey of the immunogenicity of HIV env peptides in chimpanzees, we have observed that HIV peptide immunogenicity was dramatically altered by the NH2-terminal ...
Frost P, Arthur L O, Langlois A J
exaly   +3 more sources

Modulation of Cytokine Production by the Transmembrane Envelope Protein gp41 of HIV-1 [PDF]

Retrovirology, 2005
Elevated IL-6, IL-10, IL-8, gro-alpha and TNF-alpha and decreased IL-2 values have been regularly observed in HIV infected individuals. To study the influence of the transmembrane envelope protein gp41 of HIV-1 on the cytokine production by human blood donor PBMCs, additional cytokine arrays (RayBiotech) that measured the release of about 100 cytokines,
Behrendt Rayk, Denner Joachim, Kurth Reinhard   +2 more
doaj   +3 more sources

The Polar Region of the HIV-1 Envelope Protein Determines Viral Fusion and Infectivity by Stabilizing the gp120-gp41 Association [PDF]

Journal of Virology, 2019
Although extensive studies of the transmembrane unit (gp41) of HIV-1 Env have led to a fusion inhibitor clinically used to block viral entry, the functions of different domains of gp41 in HIV-1 fusion and infectivity are not fully elucidated. The polar region (PR) of gp41 has been proposed to participate in HIV-1 membrane fusion in biochemical analyses,
Yong Xiong, Nathan Sherer, Jingyou Yu
exaly   +3 more sources

Python-driven impedance profiling on peptide-functionalized biosensor for detection of HIV gp41 envelope protein. [PDF]

3 Biotech
Abstract This study presents the first label-free impedimetric biosensor for the detection of HIV envelope protein gp41 using antimicrobial peptides (AMPs) as biorecognition receptors. The biosensor interface was enhanced with thiolated polystyrene and gold nanospheres to ensure stable peptide immobilization and resist nonspecific adsorption.
Ezer M, Uygun ZO.
europepmc   +3 more sources

Induction of HIV Neutralizing Antibodies against the MPER of the HIV Envelope Protein by HA/gp41 Chimeric Protein-Based DNA and VLP Vaccines

PLoS ONE, 2011
Several conserved neutralizing epitopes have been identified in the HIV Env protein and among these, the MPER of gp41 has received great attention and is widely recognized as a promising target. However, little success has been achieved in eliciting MPER-specific HIV neutralizing antibodies by a number of different vaccine strategies.
Zhigao Bu, Chinglai Yang, Richard Compans   +2 more
exaly   +4 more sources

A modification to heptad repeat 1 of gp41 improves yield and/or quality of soluble pre-fusion HIV-1 envelope glycoprotein trimers [PDF]

Journal of Virology
Native-like HIV-1 envelope glycoprotein (Env) trimers, exemplified by the SOSIP design, are widely used as immunogens, analytical antigens, and for structural studies.
Devidas N. Chaturbhuj, Kwinten Sliepen, Albert Cupo, Benjamin Steinberg, Simon Kazimierczyk, Tarek Munawar, Kyle Kramer, Anila Yasmeen, Thales G. Andrade, Wen-Hsin Lee, Lara van der Maas, Grace Gibson, Oscar Feliciano, Ivan del Moral Sanchez, Edith Schermer, Rhianna Bronson, Alison Benner, Madhu Prabhakaran, Rosemarie Mason, P. J. Klasse, Andrew B. Ward, Gabriel Ozorowski, Rogier W. Sanders, John P. Moore   +23 more
doaj   +2 more sources

J3ExoA: A Novel Anti-HIV Immunotoxin Fusion of Anti-Gp120 J3VHH and PE38 Fragment of Pseudomonas Exotoxin A [PDF]

Pharmaceuticals
Background. We are developing cytotoxic anti-HIV immunoconjugates to attack the reservoir of infected cells that persist after years of fully suppressive anti-retroviral therapy. Methods.
Seth H. Pincus, Kun Luo, Tami Peters, James T. Gordy, Frances M. Cole, Grant Klug, Kelli Ober, Tamera K. Marcotte, Richard B. Markham   +8 more
doaj   +2 more sources

Plant Lectin, MoMo30, Pressures HIV-1 to Select for Variants with Deleted N-Linked Glycosylation Sites [PDF]

Viruses
Momordica balsamina, a plant traditionally used in African medicine, contains a 30 kDa protein, MoMo30, previously identified by our group as an anti-HIV agent that binds glycan residues on the gp120 envelope protein, thereby acting as an entry inhibitor.
Morgan I. Coleman, Mahfuz B. Khan, Erick Gbodossou, Amad Diop, Kenya DeBarros, Vincent C. Bond, Virginia Floyd, Kofi Kondwani, Valerie Montgomery Rice, Michael D. Powell   +9 more
doaj   +2 more sources