Results 41 to 50 of about 9,575 (175)

Microbial Protein Binding to gC1qR Drives PLA2G1B-Induced CD4 T-Cell Anergy

Frontiers in Immunology, 2022
The origin of the impaired CD4 T-cell response and immunodeficiency of HIV-infected patients is still only partially understood. We recently demonstrated that PLA2G1B phospholipase synergizes with the HIV gp41 envelope protein in HIV viremic plasma to ...
Julien Pothlichet, Annalisa Meola, Florence Bugault, Louise Jeammet, Anne G. Savitt, Berhane Ghebrehiwet, Lhousseine Touqui, Lhousseine Touqui, Philippe Pouletty, Frédéric Fiore, Alain Sauvanet, Jacques Thèze   +11 more
doaj   +1 more source

Conserved Residue Asn-145 in the C-Terminal Heptad Repeat Region of HIV-1 gp41 is Critical for Viral Fusion and Regulates the Antiviral Activity of Fusion Inhibitors

Viruses, 2019
Entry of HIV-1 into target cells is mediated by its envelope (Env) glycoprotein composed of the receptor binding subunit gp120 and the fusion protein gp41. Refolding of the gp41 N- and C-terminal heptad repeats (NHR and CHR) into a six-helix bundle (6-HB)
Xiuzhu Geng, Zixuan Liu, Danwei Yu, Bo Qin, Yuanmei Zhu, Sheng Cui, Huihui Chong, Yuxian He   +7 more
doaj   +1 more source

Identification of variant HIV envelope proteins with enhanced affinities for precursors to anti-gp41 broadly neutralizing antibodies

PLOS ONE, 2019
HIV envelope protein (Env) is the sole target of broadly neutralizing antibodies (BNAbs) that are capable of neutralizing diverse strains of HIV. While BNAbs develop spontaneously in a subset of HIV-infected patients, efforts to design an envelope protein-based immunogen to elicit broadly neutralizing antibody responses have so far been unsuccessful ...
Hong Zhu, Elizabeth Mathew, Sara M. Connelly, Jeffrey Zuber, Mark Sullivan, Michael S. Piepenbrink, James J. Kobie, Mark E. Dumont   +7 more
openaire   +4 more sources

Evaluation of the potency of the anti-idiotypic antibody Ab2/3H6 mimicking gp41 as an HIV-1 vaccine in a rabbit prime/boost study.

PLoS ONE, 2012
The HIV-1 envelope protein harbors several conserved epitopes that are recognized by broadly neutralizing antibodies. One of these neutralizing sites, the MPER region of gp41, is targeted by one of the most potent and broadly neutralizing monoclonal ...
Alexander Mader, Renate Kunert
doaj   +1 more source

Inhibition of Viral Membrane Fusion by Peptides and Approaches to Peptide Design

Pathogens, 2021
Fusion of lipid-enveloped viruses with the cellular plasma membrane or the endosome membrane is mediated by viral envelope proteins that undergo large conformational changes following binding to receptors.
Nejat Düzgüneş, Narcis Fernandez-Fuentes, Krystyna Konopka   +2 more
doaj   +1 more source

Viral envelope protein folding and membrane hemifusion are enhanced by the conserved loop region of HIV‐1 gp41

The FASEB Journal, 2011
ABSTRACT Fusion of human immunodeficiency virus (HIV‐1) with target cells is mediated by the gp41 transmembrane envelope protein. The loop region within gp41 contains 2 crucial cysteines that play an unknown role in HIV‐cell fusion. On the basis of cell‐cell fusion assay,
Avraham, Ashkenazi, Mathias, Viard, Yael, Wexler-Cohen, Robert, Blumenthal, Yechiel, Shai   +4 more
openaire   +3 more sources

Biochemistry and Biophysics of HIV-1 gp41 - Membrane Interactions and Implications for HIV-1 Envelope Protein Mediated Viral-Cell Fusion and Fusion Inhibitor Design [PDF]

Current Topics in Medicinal Chemistry, 2011
Human immunodeficiency virus type 1 (HIV-1), the pathogen of acquired immunodeficiency syndrome (AIDS), causes ~2 millions death every year and still defies an effective vaccine. HIV-1 infects host cells through envelope protein - mediated virus-cell fusion.
Lifeng, Cai, Miriam, Gochin, Keliang, Liu   +2 more
openaire   +2 more sources

Bifunctional recombinant fusion proteins for rapid detection of antibodies to both HIV-1 and HIV-2 in whole blood

BMC Biotechnology, 2006
Background Availability of accurate diagnostic tests has been helpful in curtailing the spread of HIV infection. Among these, simple, point of care, inexpensive tests which require only a drop of blood from finger-prick and give reliable results within ...
Chaudhary Vijay K, Gupta Amita
doaj   +1 more source

Identification of the gC1qR sites for the HIV-1 viral envelope protein gp41 and the HCV core protein: Implications in viral-specific pathogenesis and therapy [PDF]

Molecular Immunology, 2016
A substantial body of evidence accumulated over the past 20 years supports the concept that gC1qR is a major pathogen-associated pattern recognition receptor (PRR). This conclusion is based on the fact that, a wide range of bacterial and viral ligands are able to exploit gC1qR to either suppress the host's immune response and thus enhance their ...
Pednekar, L, Valentino, A, Ji, Y, Tumma, N, Valentino, C, Kadoor, A, Hosszu, KK, Ramadass, M, Kew, RR, Kishore, U, Peerschke, EIB, Ghebrehiwet, B   +11 more
openaire   +3 more sources

Nonneutralizing HIV-1 gp41 Envelope Cluster II Human Monoclonal Antibodies Show Polyreactivity for Binding to Phospholipids and Protein Autoantigens [PDF]

Journal of Virology, 2011
ABSTRACT HIV-1 gp41 envelope antibodies, which are frequently induced in HIV-1-infected individuals, are predominantly nonneutralizing. The rare and difficult-to-induce neutralizing antibodies (2F5 and 4E10) that target gp41 membrane-proximal epitopes (MPER) are polyspecific and require lipid binding for HIV-1 ...
S Moses, Dennison, Kara, Anasti, Richard M, Scearce, Laura, Sutherland, Robert, Parks, Shi-Mao, Xia, Hua-Xin, Liao, Miroslaw K, Gorny, Susan, Zolla-Pazner, Barton F, Haynes, S Munir, Alam   +10 more
openaire   +2 more sources