Results 21 to 30 of about 10,100 (210)

Identification of HIV gp41-specific antibodies that mediate killing of infected cells.

PLoS Pathogens, 2019
Antibodies that mediate killing of HIV-infected cells through antibody-dependent cellular cytotoxicity (ADCC) have been implicated in protection from HIV infection and disease progression.
Katherine L Williams, Megan Stumpf, Nicole Elise Naiman, Shilei Ding, Meghan Garrett, Theodore Gobillot, Dani Vézina, Katharine Dusenbury, Nitya S Ramadoss, Ryan Basom, Peter S Kim, Andrés Finzi, Julie Overbaugh   +12 more
doaj   +2 more sources

Membrane topology analysis of HIV-1 envelope glycoprotein gp41 [PDF]

Retrovirology, 2010
Background The gp41 subunit of the HIV-1 envelope glycoprotein (Env) has been widely regarded as a type I transmembrane protein with a single membrane-spanning domain (MSD). An alternative topology model suggested multiple MSDs.
Xiao Dan, Long Yufei, Kondo Naoyuki, Liu Shujun, Iwamoto Aikichi, Matsuda Zene   +5 more
doaj   +2 more sources

Design, production, and functional and structural characterization of HIV-1 envelope protein gp41 ectodomain

, 2014
HIV is an enveloped virus which causes acquired immune deficiency syndrome in humans. HIV infects the host T-cells and macrophages and deteriorates the whole immune system.
Banerjee, Koyeli
openaire   +2 more sources

A modification to heptad repeat 1 of gp41 improves yield and/or quality of soluble pre-fusion HIV-1 envelope glycoprotein trimers [PDF]

Journal of Virology
Native-like HIV-1 envelope glycoprotein (Env) trimers, exemplified by the SOSIP design, are widely used as immunogens, analytical antigens, and for structural studies.
Devidas N. Chaturbhuj, Kwinten Sliepen, Albert Cupo, Benjamin Steinberg, Simon Kazimierczyk, Tarek Munawar, Kyle Kramer, Anila Yasmeen, Thales G. Andrade, Wen-Hsin Lee, Lara van der Maas, Grace Gibson, Oscar Feliciano, Ivan del Moral Sanchez, Edith Schermer, Rhianna Bronson, Alison Benner, Madhu Prabhakaran, Rosemarie Mason, P. J. Klasse, Andrew B. Ward, Gabriel Ozorowski, Rogier W. Sanders, John P. Moore   +23 more
doaj   +2 more sources

Plant Lectin, MoMo30, Pressures HIV-1 to Select for Variants with Deleted N-Linked Glycosylation Sites [PDF]

Viruses
Momordica balsamina, a plant traditionally used in African medicine, contains a 30 kDa protein, MoMo30, previously identified by our group as an anti-HIV agent that binds glycan residues on the gp120 envelope protein, thereby acting as an entry inhibitor.
Morgan I. Coleman, Mahfuz B. Khan, Erick Gbodossou, Amad Diop, Kenya DeBarros, Vincent C. Bond, Virginia Floyd, Kofi Kondwani, Valerie Montgomery Rice, Michael D. Powell   +9 more
doaj   +2 more sources

J3ExoA: A Novel Anti-HIV Immunotoxin Fusion of Anti-Gp120 J3VHH and PE38 Fragment of Pseudomonas Exotoxin A [PDF]

Pharmaceuticals
Background. We are developing cytotoxic anti-HIV immunoconjugates to attack the reservoir of infected cells that persist after years of fully suppressive anti-retroviral therapy. Methods.
Seth H. Pincus, Kun Luo, Tami Peters, James T. Gordy, Frances M. Cole, Grant Klug, Kelli Ober, Tamera K. Marcotte, Richard B. Markham   +8 more
doaj   +2 more sources

Detection of antibodies to p24 and gp41 epitopes of HIV by ELISA using the recombinant core protein (p24) and envelope synthetic protein (gp41).

Microbiologica, 1991
We have developed a system consisting of two separate ELISA, one designed to detect antibodies to HIV gag gene (p24) and the other to detect antibodies to HIV env gene (gp41). The antigen used in these ELISA was produced as recombinant DNA-derived proteins expressed in E.
FILICE, GAETANO, Soldini L., ORSOLINI, PAOLO, Razzini E., Chiapparoli L., GUlminetti R., Cattaneo E., Achilli G.   +7 more
openaire   +2 more sources

IGHV1-69 B cell chronic lymphocytic leukemia antibodies cross-react with HIV-1 and hepatitis C virus antigens as well as intestinal commensal bacteria. [PDF]

PLoS ONE, 2014
B-cell chronic lymphocytic leukemia (B-CLL) patients expressing unmutated immunoglobulin heavy variable regions (IGHVs) use the IGHV1-69 B cell receptor (BCR) in 25% of cases.
Kwan-Ki Hwang, Ashley M Trama, Daniel M Kozink, Xi Chen, Kevin Wiehe, Abby J Cooper, Shi-Mao Xia, Minyue Wang, Dawn J Marshall, John Whitesides, Munir Alam, Georgia D Tomaras, Steven L Allen, Kanti R Rai, Jane McKeating, Rosa Catera, Xiao-Jie Yan, Charles C Chu, Garnett Kelsoe, Hua-Xin Liao, Nicholas Chiorazzi, Barton F Haynes   +21 more
doaj   +1 more source

Python-driven impedance profiling on peptide-functionalized biosensor for detection of HIV gp41 envelope protein. [PDF]

3 Biotech
Abstract This study presents the first label-free impedimetric biosensor for the detection of HIV envelope protein gp41 using antimicrobial peptides (AMPs) as biorecognition receptors. The biosensor interface was enhanced with thiolated polystyrene and gold nanospheres to ensure stable peptide immobilization and resist nonspecific adsorption.
Ezer M, Uygun ZO.
europepmc   +3 more sources

Identification of Anti-gp41 Monoclonal Antibodies That Effectively Target Cytotoxic Immunoconjugates to Cells Infected with Human Immunodeficiency Virus, Type 1

Vaccines, 2023
We are developing cytotoxic immunoconjugates (CICs) targeting the envelope protein (Env) of the Human Immunodeficiency Virus, type 1 (HIV) to purge the persistent reservoirs of viral infection.
Grant Klug, Frances M. Cole, Mark D. Hicar, Connie Watt, Tami Peters, Seth H. Pincus   +5 more
doaj   +1 more source