Results 31 to 40 of about 4,355,851 (162)

Impact of stabilizing mutations on the antigenic profile and glycosylation of membrane-expressed HIV-1 envelope glycoprotein.

PLoS Pathogens, 2023
Recent HIV-1 vaccine development has centered on "near native" soluble envelope glycoprotein (Env) trimers that are artificially stabilized laterally (between protomers) and apically (between gp120 and gp41).
Tommy Tong, Alessio D'Addabbo, Jiamin Xu, Himanshi Chawla, Albert Nguyen, Paola Ochoa, Max Crispin, James M Binley   +7 more
doaj   +1 more source

Evaluating the neutralizing antibody response to HIV-1 membrane proximal external regional; Implications for vaccine design [PDF]

, 2014
Includes bibliographical references.Inducing broadly neutralizing antibodies targeting the HIV-1 envelope is thought to be crucial for developing an effective vaccine.
Jacob, Rajesh Abraham
core   +1 more source

Development and evaluation of a differential diagnostic test strip for antibodies induced by HIV-1 vaccine and natural infections

Di-san junyi daxue xuebao, 2019
Objective To develop a differential diagnostic kit for distinguishing antibodies induced by HIV-1 infection and HIV-1 vaccine and evaluate its diagnostic performance.
YUAN Zuowei, WANG Yonghong, HUANG Jun, YE Yangmin   +3 more
doaj   +1 more source

Molecular footprint of drug-selective pressure in a human immunodeficiency virus transmission chain [PDF]

, 2005
Known human immunodeficiency virus (HIV) transmission histories are invaluable models for investigating the evolutionary and transmission dynamics of the virus and to assess the accuracy of phylogenetic reconstructions.
A.-M. Vandamme, Lemey, P, A. Rambaut, Dumont, Stephanie, S. Dumont, Van Wijngaerden, Eric, Vandamme, A M, K. Van Laethem, Rambaut, Andrew, Vermeulen, Steve, S. Vermeulen, E. Van Wijngaerden, Dumont, S, Vandamme, Anne-Mieke, P. Lemey, Rambaut, A, Van Laethem, Kristel, Lemey, Philippe, I. Derdelinckx, Van Wijngaerden, E, Derdelinckx, Inge, Vermeulen, S, Van Laethem, K, Derdelinckx, I   +23 more
core   +1 more source

Analysis of the subunit stoichiometries in viral entry. [PDF]

PLoS ONE, 2012
Virions of the Human Immunodeficiency Virus (HIV) infect cells by first attaching with their surface spikes to the CD4 receptor on target cells. This leads to conformational changes in the viral spikes, enabling the virus to engage a coreceptor, commonly
Carsten Magnus, Roland R Regoes
doaj   +1 more source

Phase I Randomised Clinical Trial of an HIV-1(CN54), Clade C, Trimeric Envelope Vaccine Candidate Delivered Vaginally. [PDF]

, 2011
We conducted a phase 1 double-blind randomised controlled trial (RCT) of a HIV-1 envelope protein (CN54 gp140) candidate vaccine delivered vaginally to assess immunogenicity and safety.
Fraser Carol A., Wiggins, RC, Cai Chun, David J Lewis, David J. Lewis, Maria Woodrow, Martin P. Cranage, Manoussaka, Maria, Wiggins Rebecca C., Giemza, Rafaela, Giemza Rafaela, Fraser, CA, Alethea Cope, Cai, Chun, Lacey, Charles J, Cranage Martin P., Cai, C, Cope Alethea, Abdel N Mahmoud, Cope, A, Tom Cole, Robin J Shattock, Jeffs, Simon A, Shattock, RJ, Rebecca C. Wiggins, Maria Manoussaka, Charles J Lacey, Charles J. Lacey, Manoussaka Maria, Cranage, Martin P, Cole Tom, Martin P Cranage, Lewis David J., Shattock, Robin J, Lacey, CJ, Jeffs Simon A., Woodrow, M, Manoussaka, M, Lewis, David J, Rafaela Giemza, Chun Cai, Mahmoud Abdel N., Robin J. Shattock, Wiggins, Rebecca C, Cole, Tom, Simon A. Jeffs, Shattock Robin J., Fraser, Carol A, Mahmoud, AN, Simon A Jeffs, Lewis, DJ, Giemza, R, Carol A Fraser, Woodrow, Maria, Jeffs, SA, Carol A. Fraser, Woodrow Maria, Cole, T, Cope, Alethea, Abdel N. Mahmoud, Mahmoud, Abdel N, Rebecca C Wiggins, Cranage, MP, Lacey Charles J.   +63 more
core   +2 more sources

HIV-1 Envelope Glycoprotein Amino Acids Signatures Associated with Clade B Transmitted/Founder and Recent Viruses

Viruses, 2019
Background: HIV-1 transmitted/founder viruses (TF) are selected during the acute phase of infection from a multitude of virions present during transmission.
Alexis Kafando, Christine Martineau, Mohamed El-Far, Eric Fournier, Florence Doualla-Bell, Bouchra Serhir, Adama Kazienga, Mohamed Ndongo Sangaré, Mohamed Sylla, Annie Chamberland, Hugues Charest, Cécile L. Tremblay   +11 more
doaj   +1 more source

Multimeric scaffolds displaying the HIV-1 envelope MPER induce MPER-specific antibodies and cross-neutralizing antibodies when co-immunized with gp160 DNA. [PDF]

PLoS ONE, 2014
Developing a vaccine that overcomes the diversity of HIV-1 is likely to require a strategy that directs antibody (Ab) responses toward conserved regions of the viral Envelope (Env).
Shelly J Krebs, Sean P McBurney, Dina N Kovarik, Chelsea D Waddell, J Pablo Jaworski, William F Sutton, Michelle M Gomes, Maria Trovato, Garret Waagmeester, Susan J Barnett, Piergiuseppe DeBerardinis, Nancy L Haigwood   +11 more
doaj   +1 more source

Genetic and immunological characterization of new subtype G envelope expressing HIV-1 pseudoviruses [PDF]

, 2014
Includes bibliographical references.One of the greatest challenges for the development of an effective HIV-1 vaccine is the high genetic diversity of this pathogen and the complex escape mechanisms employed by the envelope gp120 and gp41 glycoprotein ...
Essomba, Rene Ghislain
core   +1 more source

Modulation of cytokine release and gene expression by the immunosuppressive domain of gp41 of HIV-1.

PLoS ONE, 2013
The transmembrane envelope protein gp41 of the human immunodeficiency virus HIV-1 plays an important role during infection allowing fusion of the viral and cellular membrane.
Joachim Denner, Magdalena Eschricht, Michael Lauck, Marwan Semaan, Philipp Schlaermann, Hyunmi Ryu, Levent Akyüz   +6 more
doaj   +1 more source