Results 31 to 40 of about 9,575 (175)

HIV-1 Envelope Glycoprotein Amino Acids Signatures Associated with Clade B Transmitted/Founder and Recent Viruses

Viruses, 2019
Background: HIV-1 transmitted/founder viruses (TF) are selected during the acute phase of infection from a multitude of virions present during transmission.
Alexis Kafando, Christine Martineau, Mohamed El-Far, Eric Fournier, Florence Doualla-Bell, Bouchra Serhir, Adama Kazienga, Mohamed Ndongo Sangaré, Mohamed Sylla, Annie Chamberland, Hugues Charest, Cécile L. Tremblay   +11 more
doaj   +1 more source

Analysis of the subunit stoichiometries in viral entry. [PDF]

PLoS ONE, 2012
Virions of the Human Immunodeficiency Virus (HIV) infect cells by first attaching with their surface spikes to the CD4 receptor on target cells. This leads to conformational changes in the viral spikes, enabling the virus to engage a coreceptor, commonly
Carsten Magnus, Roland R Regoes
doaj   +1 more source

Modulation of cytokine release and gene expression by the immunosuppressive domain of gp41 of HIV-1.

PLoS ONE, 2013
The transmembrane envelope protein gp41 of the human immunodeficiency virus HIV-1 plays an important role during infection allowing fusion of the viral and cellular membrane.
Joachim Denner, Magdalena Eschricht, Michael Lauck, Marwan Semaan, Philipp Schlaermann, Hyunmi Ryu, Levent Akyüz   +6 more
doaj   +1 more source

Multimeric scaffolds displaying the HIV-1 envelope MPER induce MPER-specific antibodies and cross-neutralizing antibodies when co-immunized with gp160 DNA. [PDF]

PLoS ONE, 2014
Developing a vaccine that overcomes the diversity of HIV-1 is likely to require a strategy that directs antibody (Ab) responses toward conserved regions of the viral Envelope (Env).
Shelly J Krebs, Sean P McBurney, Dina N Kovarik, Chelsea D Waddell, J Pablo Jaworski, William F Sutton, Michelle M Gomes, Maria Trovato, Garret Waagmeester, Susan J Barnett, Piergiuseppe DeBerardinis, Nancy L Haigwood   +11 more
doaj   +1 more source

Conserved positive selection signals in gp41 across multiple subtypes and difference in selection signals detectable in gp41 sequences sampled during acute and chronic HIV-1 subtype C infection

Virology Journal, 2008
Background The high diversity of HIV variants driving the global AIDS epidemic has caused many to doubt whether an effective vaccine against the virus is possible.
Karim Salim, Mlisana Koleka, Treurnicht Florette, Martin Darren P, Bandawe Gama P, Williamson Carolyn   +5 more
doaj   +1 more source

Immunisation with the membrane proximal external region of gp41 of HIV-1 grafted into the transmembrane envelope protein of a gammaretrovirus [PDF]

Retrovirology, 2012
Background Immunisation with the transmembrane envelope (TM) proteins p15E of different gammaretroviruses (e.g., porcine endogenous retrovirus, feline leukaemia virus, Koala retrovirus) resulted in strong neutralising activity, the antibodies recognised epitopes in the fusion peptide proximal region (FPPR) and in the membrane proximal external region ...
Strasz, N., Morozov, Vladimir, Kreutzberger, J., Lau, M., Denner, Joachim   +4 more
openaire   +3 more sources

Meta-analysis of HIV-1 vaccine elicited mucosal antibodies in humans

npj Vaccines, 2021
We studied mucosal immune responses in six HIV-1 vaccine trials investigating different envelope (Env)-containing immunogens. Regimens were classified into four categories: DNA/vector, DNA/vector plus protein, protein alone, and vector alone. We measured
Kelly E. Seaton, Aaron Deal, Xue Han, Shuying S. Li, Ashley Clayton, Jack Heptinstall, Ann Duerr, Mary A. Allen, Xiaoying Shen, Sheetal Sawant, Nicole L. Yates, Paul Spearman, Gavin Churchyard, Paul A. Goepfert, Janine Maenza, Glenda Gray, Giuseppe Pantaleo, Laura Polakowski, Harriet L. Robinson, Shannon Grant, April K. Randhawa, Ying Huang, Cecilia Morgan, Nicole Grunenberg, Shelly Karuna, Peter B. Gilbert, M. Juliana McElrath, Yunda Huang, Georgia D. Tomaras, NIAID HIV Vaccine Trials Network (HVTN) 076, 088, 086, 096, 097, 205 Study Teams   +29 more
doaj   +1 more source

N36, a Synthetic N-Terminal Heptad Repeat Domain of the HIV-1 Envelope Protein gp41, Is an Activator of Human Phagocytes [PDF]

Clinical Immunology, 2000
Human immunodeficiency virus type 1 (HIV-1) envelope protein gp41 mediates viral fusion with human host cells. In this study we show that N36, a synthetic peptide derived from the N-terminus of gp41, induced directional migration and calcium mobilization in human monocytes and neutrophils. The activity of N36 on phagocytes was pertussis toxin sensitive,
Le, Yingying, Jiang, Shibo, Hu, Jinyue, Gong, Wanghua, Su, Shaobo, Dunlop, Nancy M., Shen, Weiping, Li, Baoqun, Ming Wang, Ji   +8 more
openaire   +2 more sources

Heterologous epitope-scaffold prime:boosting immuno-focuses B cell responses to the HIV-1 gp41 2F5 neutralization determinant. [PDF]

PLoS ONE, 2011
The HIV-1 envelope glycoproteins (Env) gp120 and gp41 mediate entry and are the targets for neutralizing antibodies. Within gp41, a continuous epitope defined by the broadly neutralizing antibody 2F5, is one of the few conserved sites accessible to ...
Javier Guenaga, Pia Dosenovic, Gilad Ofek, David Baker, William R Schief, Peter D Kwong, Gunilla B Karlsson Hedestam, Richard T Wyatt   +7 more
doaj   +1 more source

Meeting Review: 2018 International Workshop on Structure and Function of the Lentiviral gp41 Cytoplasmic Tail

Viruses, 2018
Recent developments in defining the role of the lentiviral envelope glycoprotein (Env) cytoplasmic tail (CT) in Env trafficking and incorporation into virus particles have advanced our understanding of viral replication and transmission.
Melissa V. Fernandez, Eric O. Freed
doaj   +1 more source