Results 11 to 20 of about 10,100 (210)

Antigenic and immunosuppressive properties of a trimeric recombinant transmembrane envelope protein gp41 of HIV-1. [PDF]

PLoS ONE, 2017
The transmembrane envelope (TM) protein gp41 of the human immunodeficiency virus-1 (HIV-1) plays an important role during virus infection inducing the fusion of the viral and cellular membranes.
Michael Mühle, Melissa Lehmann, Kerstin Hoffmann, Daniel Stern, Tobias Kroniger, Werner Luttmann, Joachim Denner   +6 more
doaj   +7 more sources

HIV-1 Envelope Protein gp41: An NMR Study of Dodecyl Phosphocholine Embedded gp41 Reveals a Dynamic Prefusion Intermediate Conformation [PDF]

Structure, 2014
Human immunodeficiency viral (HIV-1) fusion is mediated by the viral envelope gp120/gp41 complex (ENVelope glycoprotein). After gp120 shedding, gp41 is exposed and elicits membrane fusion via a cascade of conformational changes. In contrast to prefusion and postfusion conformation, little is known about any intermediate conformation.
Lakomek, N., Kaufman, J., Stahl, S., Wingfield, P.   +3 more
openaire   +5 more sources

Investigating the role of a conserved hydrophobic pocket of gp41 in the anti-HIV activity of fusion inhibitors. [PDF]

Protein Sci
Abstract Membrane fusion between HIV and host cells requires interaction between the N‐terminal and C‐terminal repeat regions (NHR and CHR) of the gp41 envelope subunit. A deep hydrophobic pocket (HP) on the surface of NHR is considered crucial in this interaction.
Polo-Megías D, Cano-Muñoz M, Sánchez-Martínez L, Lestani S, Moog C, Decoville T, Salinas-García MC, Gavira JA, Cámara-Artigas A, Conejero-Lara F.   +9 more
europepmc   +2 more sources

Characterization of HIV-1 envelope gp41 genetic diversity and functional domains following perinatal transmission

Retrovirology, 2006
Background HIV-1 envelope gp41 is a transmembrane protein that promotes fusion of the virus with the plasma membrane of the host cells required for virus entry. In addition, gp41 is an important target for the immune response and development of antiviral
Davis Tiffany, Sundaravaradan Vasudha, Mehta Roshni, Ramakrishnan Rajesh, Ahmad Nafees   +4 more
doaj   +2 more sources

HIV-1 gp41 Fusion Intermediate: A Target for HIV Therapeutics

Journal of the Formosan Medical Association, 2010
Human immunodeficiency virus (HIV)-1 infection is initiated by the binding of gp120 envelope glyco-protein to its cell receptor (CD4) and a coreceptor (CXCR4 or CCR5), followed by a series of conformational changes in the gp41 transmembrane subunit ...
Chungen Pan, Shuwen Liu, Shibo Jiang
doaj   +2 more sources

Induction of antibodies in rhesus macaques that recognize a fusion-intermediate conformation of HIV-1 gp41. [PDF]

PLoS ONE, 2011
A component to the problem of inducing broad neutralizing HIV-1 gp41 membrane proximal external region (MPER) antibodies is the need to focus the antibody response to the transiently exposed MPER pre-hairpin intermediate neutralization epitope.
S Moses Dennison, Laura L Sutherland, Frederick H Jaeger, Kara M Anasti, Robert Parks, Shelley Stewart, Cindy Bowman, Shi-Mao Xia, Ruijun Zhang, Xiaoying Shen, Richard M Scearce, Gilad Ofek, Yongping Yang, Peter D Kwong, Sampa Santra, Hua-Xin Liao, Georgia Tomaras, Norman L Letvin, Bing Chen, S Munir Alam, Barton F Haynes   +20 more
doaj   +2 more sources

Evolution of the HIV-1 envelope glycoproteins with a disulfide bond between gp120 and gp41 [PDF]

Retrovirology, 2004
Background We previously described the construction of an HIV-1 envelope glycoprotein complex (Env) that is stabilized by an engineered intermolecular disulfide bond (SOS) between gp120 and gp41.
Caffrey Michael, Busser Els, Dankers Martijn M, Sanders Rogier W, Moore John P, Berkhout Ben   +5 more
doaj   +2 more sources

Nonneutralizing HIV-1 gp41 Envelope Cluster II Human Monoclonal Antibodies Show Polyreactivity for Binding to Phospholipids and Protein Autoantigens [PDF]

Journal of Virology, 2011
ABSTRACT HIV-1 gp41 envelope antibodies, which are frequently induced in HIV-1-infected individuals, are predominantly nonneutralizing. The rare and difficult-to-induce neutralizing antibodies (2F5 and 4E10) that target gp41 membrane-proximal epitopes (MPER) are polyspecific and require lipid binding for HIV-1 ...
S Moses, Dennison, Kara, Anasti, Richard M, Scearce, Laura, Sutherland, Robert, Parks, Shi-Mao, Xia, Hua-Xin, Liao, Miroslaw K, Gorny, Susan, Zolla-Pazner, Barton F, Haynes, S Munir, Alam   +10 more
openaire   +3 more sources

Evaluation of cellular proteins binding to the transmembrane envelope protein gp41 of HIV-1 [PDF]

, 2015
Das von HIV ausgelöste erwobene Immunschwäche-Syndrom (AIDS) stellt auch heute noch ein Problem dar. Im Jahr 2014 waren laut der Weltgesundheitsorganisation (WHO) 36,9 Millionen Menschen mit HIV infiziert. Heute, 30 Jahre nach der Entdeckung von HIV, gibt es zwar gute therapeutische Ansätze, eine Heilung ist aber bisher nicht in Aussicht.
Kroniger, Tobias
openaire   +3 more sources

The membrane-spanning domain of gp41 plays a critical role in intracellular trafficking of the HIV envelope protein [PDF]

Retrovirology, 2010
AbstractBackgroundThe sequences of membrane-spanning domains (MSDs) on the gp41 subunit are highly conserved among many isolates of HIV-1. The GXXXG motif, a potential helix-helix interaction motif, and an arginine residue (rare in hydrophobic MSDs) are especially well conserved. These two conserved elements are expected to locate on the opposite sides
Kondo Naoyuki, Long Yufei, Curran A Rachael, Miyauchi Kosuke, Iwamoto Aikichi, Engelman Donald M, Matsuda Zene   +6 more
openaire   +4 more sources