Results 11 to 20 of about 9,575 (175)

IGHV1-69 B cell chronic lymphocytic leukemia antibodies cross-react with HIV-1 and hepatitis C virus antigens as well as intestinal commensal bacteria. [PDF]

PLoS ONE, 2014
B-cell chronic lymphocytic leukemia (B-CLL) patients expressing unmutated immunoglobulin heavy variable regions (IGHVs) use the IGHV1-69 B cell receptor (BCR) in 25% of cases.
Kwan-Ki Hwang, Ashley M Trama, Daniel M Kozink, Xi Chen, Kevin Wiehe, Abby J Cooper, Shi-Mao Xia, Minyue Wang, Dawn J Marshall, John Whitesides, Munir Alam, Georgia D Tomaras, Steven L Allen, Kanti R Rai, Jane McKeating, Rosa Catera, Xiao-Jie Yan, Charles C Chu, Garnett Kelsoe, Hua-Xin Liao, Nicholas Chiorazzi, Barton F Haynes   +21 more
doaj   +1 more source

Induction of antibodies in rhesus macaques that recognize a fusion-intermediate conformation of HIV-1 gp41. [PDF]

PLoS ONE, 2011
A component to the problem of inducing broad neutralizing HIV-1 gp41 membrane proximal external region (MPER) antibodies is the need to focus the antibody response to the transiently exposed MPER pre-hairpin intermediate neutralization epitope.
S Moses Dennison, Laura L Sutherland, Frederick H Jaeger, Kara M Anasti, Robert Parks, Shelley Stewart, Cindy Bowman, Shi-Mao Xia, Ruijun Zhang, Xiaoying Shen, Richard M Scearce, Gilad Ofek, Yongping Yang, Peter D Kwong, Sampa Santra, Hua-Xin Liao, Georgia Tomaras, Norman L Letvin, Bing Chen, S Munir Alam, Barton F Haynes   +20 more
doaj   +1 more source

HIV-1 Envelope Protein gp41: An NMR Study of Dodecyl Phosphocholine Embedded gp41 Reveals a Dynamic Prefusion Intermediate Conformation [PDF]

Structure, 2014
Human immunodeficiency viral (HIV-1) fusion is mediated by the viral envelope gp120/gp41 complex (ENVelope glycoprotein). After gp120 shedding, gp41 is exposed and elicits membrane fusion via a cascade of conformational changes. In contrast to prefusion and postfusion conformation, little is known about any intermediate conformation.
Lakomek, N., Kaufman, J., Stahl, S., Wingfield, P.   +3 more
openaire   +3 more sources

Identification of Anti-gp41 Monoclonal Antibodies That Effectively Target Cytotoxic Immunoconjugates to Cells Infected with Human Immunodeficiency Virus, Type 1

Vaccines, 2023
We are developing cytotoxic immunoconjugates (CICs) targeting the envelope protein (Env) of the Human Immunodeficiency Virus, type 1 (HIV) to purge the persistent reservoirs of viral infection.
Grant Klug, Frances M. Cole, Mark D. Hicar, Connie Watt, Tami Peters, Seth H. Pincus   +5 more
doaj   +1 more source

The membrane-spanning domain of gp41 plays a critical role in intracellular trafficking of the HIV envelope protein [PDF]

Retrovirology, 2010
AbstractBackgroundThe sequences of membrane-spanning domains (MSDs) on the gp41 subunit are highly conserved among many isolates of HIV-1. The GXXXG motif, a potential helix-helix interaction motif, and an arginine residue (rare in hydrophobic MSDs) are especially well conserved. These two conserved elements are expected to locate on the opposite sides
Kondo Naoyuki, Long Yufei, Curran A Rachael, Miyauchi Kosuke, Iwamoto Aikichi, Engelman Donald M, Matsuda Zene   +6 more
openaire   +3 more sources

Sensitive detection systems for infectious agents in xenotransplantation*

Xenotransplantation, EarlyView., 2020
Abstract Xenotransplantation of pig cells, tissues, or organs may be associated with transmission of porcine microorganisms, first of all of viruses, to the transplant recipient, potentially inducing a disease (zoonosis). I would like to define detection systems as the complex of sample generation, sample preparation, sample origin, time of sampling ...
Joachim Denner
wiley   +1 more source

Immunogens Modeling a Fusion-Intermediate Conformation of gp41 Elicit Antibodies to the Membrane Proximal External Region of the HIV Envelope Glycoprotein. [PDF]

PLoS ONE, 2015
The membrane proximal external region (MPER) of the gp41 subunit of the HIV-1 envelope glycoprotein (Env) contains determinants for broadly neutralizing antibodies and has remained an important focus of vaccine design. However, creating an immunogen that
Russell Vassell, Yong He, Prasad Vennakalanti, Antu K Dey, Min Zhuang, Wei Wang, Yide Sun, Zohar Biron-Sorek, Indresh K Srivastava, Celia C LaBranche, David C Montefiori, Susan W Barnett, Carol D Weiss   +12 more
doaj   +1 more source

Expression of Foreign Proteins on the Surface of Autographa Californica Nuclear Polyhedrosis Virus

BioTechniques, 1997
Based on the method of direct cloning into the baculovirus genome by linearizing and re-ligation in presence of the target insert, we designed viral constructs that express foreign genes on the surface o baculovirus particles.
R. Grabherr, W. Ernst, O. Doblhoff-Dier, M. Sara, H. Katinger   +4 more
doaj   +1 more source

HIV-1 gp41 Fusion Intermediate: A Target for HIV Therapeutics

Journal of the Formosan Medical Association, 2010
Human immunodeficiency virus (HIV)-1 infection is initiated by the binding of gp120 envelope glyco-protein to its cell receptor (CD4) and a coreceptor (CXCR4 or CCR5), followed by a series of conformational changes in the gp41 transmembrane subunit ...
Chungen Pan, Shuwen Liu, Shibo Jiang
doaj   +1 more source

Characterization of HIV-1 envelope gp41 genetic diversity and functional domains following perinatal transmission

Retrovirology, 2006
Background HIV-1 envelope gp41 is a transmembrane protein that promotes fusion of the virus with the plasma membrane of the host cells required for virus entry. In addition, gp41 is an important target for the immune response and development of antiviral
Davis Tiffany, Sundaravaradan Vasudha, Mehta Roshni, Ramakrishnan Rajesh, Ahmad Nafees   +4 more
doaj   +1 more source