Results 11 to 20 of about 4,355,851 (162)

HIV-1 gp41 Fusion Intermediate: A Target for HIV Therapeutics

Journal of the Formosan Medical Association, 2010
Human immunodeficiency virus (HIV)-1 infection is initiated by the binding of gp120 envelope glyco-protein to its cell receptor (CD4) and a coreceptor (CXCR4 or CCR5), followed by a series of conformational changes in the gp41 transmembrane subunit ...
Chungen Pan, Shuwen Liu, Shibo Jiang
doaj   +2 more sources

Characterization of HIV-1 envelope gp41 genetic diversity and functional domains following perinatal transmission [PDF]

Retrovirology, 2006
Background HIV-1 envelope gp41 is a transmembrane protein that promotes fusion of the virus with the plasma membrane of the host cells required for virus entry. In addition, gp41 is an important target for the immune response and development of antiviral
Davis Tiffany, Sundaravaradan Vasudha, Mehta Roshni, Ramakrishnan Rajesh, Ahmad Nafees   +4 more
doaj   +2 more sources

Evolution of the HIV-1 envelope glycoproteins with a disulfide bond between gp120 and gp41 [PDF]

Retrovirology, 2004
Background We previously described the construction of an HIV-1 envelope glycoprotein complex (Env) that is stabilized by an engineered intermolecular disulfide bond (SOS) between gp120 and gp41.
Caffrey Michael, Busser Els, Dankers Martijn M, Sanders Rogier W, Moore John P, Berkhout Ben   +5 more
doaj   +2 more sources

Nonneutralizing HIV-1 gp41 Envelope Cluster II Human Monoclonal Antibodies Show Polyreactivity for Binding to Phospholipids and Protein Autoantigens [PDF]

Journal of Virology, 2011
ABSTRACT HIV-1 gp41 envelope antibodies, which are frequently induced in HIV-1-infected individuals, are predominantly nonneutralizing. The rare and difficult-to-induce neutralizing antibodies (2F5 and 4E10) that target gp41 membrane-proximal epitopes (MPER) are polyspecific and require lipid binding for HIV-1 ...
S Moses, Dennison, Kara, Anasti, Richard M, Scearce, Laura, Sutherland, Robert, Parks, Shi-Mao, Xia, Hua-Xin, Liao, Miroslaw K, Gorny, Susan, Zolla-Pazner, Barton F, Haynes, S Munir, Alam   +10 more
openaire   +3 more sources

Identification of HIV gp41-specific antibodies that mediate killing of infected cells.

PLoS Pathogens, 2019
Antibodies that mediate killing of HIV-infected cells through antibody-dependent cellular cytotoxicity (ADCC) have been implicated in protection from HIV infection and disease progression.
Katherine L Williams, Megan Stumpf, Nicole Elise Naiman, Shilei Ding, Meghan Garrett, Theodore Gobillot, Dani Vézina, Katharine Dusenbury, Nitya S Ramadoss, Ryan Basom, Peter S Kim, Andrés Finzi, Julie Overbaugh   +12 more
doaj   +2 more sources

Induction of HIV Neutralizing Antibodies against the MPER of the HIV Envelope Protein by HA/gp41 Chimeric Protein-Based DNA and VLP Vaccines [PDF]

PLoS ONE, 2011
Several conserved neutralizing epitopes have been identified in the HIV Env protein and among these, the MPER of gp41 has received great attention and is widely recognized as a promising target. However, little success has been achieved in eliciting MPER-specific HIV neutralizing antibodies by a number of different vaccine strategies.
Ling Ye, Zhiyuan Wen, Ke Dong, Xi Wang, Zhigao Bu, Huizhong Zhang, Richard W Compans, Chinglai Yang   +7 more
openaire   +4 more sources

Membrane topology analysis of HIV-1 envelope glycoprotein gp41 [PDF]

Retrovirology, 2010
Background The gp41 subunit of the HIV-1 envelope glycoprotein (Env) has been widely regarded as a type I transmembrane protein with a single membrane-spanning domain (MSD). An alternative topology model suggested multiple MSDs.
Xiao Dan, Long Yufei, Kondo Naoyuki, Liu Shujun, Iwamoto Aikichi, Matsuda Zene   +5 more
doaj   +2 more sources

The membrane-spanning domain of gp41 plays a critical role in intracellular trafficking of the HIV envelope protein [PDF]

Retrovirology, 2010
AbstractBackgroundThe sequences of membrane-spanning domains (MSDs) on the gp41 subunit are highly conserved among many isolates of HIV-1. The GXXXG motif, a potential helix-helix interaction motif, and an arginine residue (rare in hydrophobic MSDs) are especially well conserved. These two conserved elements are expected to locate on the opposite sides
Kondo Naoyuki, Long Yufei, Curran A Rachael, Miyauchi Kosuke, Iwamoto Aikichi, Engelman Donald M, Matsuda Zene   +6 more
openaire   +3 more sources

Sensitive detection systems for infectious agents in xenotransplantation*

Xenotransplantation, EarlyView., 2020
Abstract Xenotransplantation of pig cells, tissues, or organs may be associated with transmission of porcine microorganisms, first of all of viruses, to the transplant recipient, potentially inducing a disease (zoonosis). I would like to define detection systems as the complex of sample generation, sample preparation, sample origin, time of sampling ...
Joachim Denner
wiley   +1 more source

Identification of Anti-gp41 Monoclonal Antibodies That Effectively Target Cytotoxic Immunoconjugates to Cells Infected with Human Immunodeficiency Virus, Type 1

Vaccines, 2023
We are developing cytotoxic immunoconjugates (CICs) targeting the envelope protein (Env) of the Human Immunodeficiency Virus, type 1 (HIV) to purge the persistent reservoirs of viral infection.
Grant Klug, Frances M. Cole, Mark D. Hicar, Connie Watt, Tami Peters, Seth H. Pincus   +5 more
doaj   +1 more source