Results 61 to 70 of about 4,355,851 (162)

Data presented in Multi-trial analysis of HIV-1 envelope gp41-reactive antibodies among global recipients of candidate HIV-1 vaccines

, 2022
This folder contains datasets analyzed in the manuscript: Multi-trial analysis of HIV-1 envelope gp41-reactive antibodies among global recipients of candidate HIV-1 vaccines. Frontiers in Immunology Sec. Vaccines and Molecular Therapeutics doi: 10.3389/
Koshlan Mayer-Blackwell, Koshlan Mayer-Blackwell (13839136), Nicole Potchen (13839258), Samuel S. Minot (10753084), Xiaoying Shen, Samuel S Minot, Jack Heptinstall, Georgia D. Tomaras, Jack Heptinstall (13839263), Andrew M. Johnson (13839252), Andrew M. Johnson, Kelly Seaton (13839267), Georgia D. Tomaras (13839296), James G. Kublin (13839301), James G Kublin, Kelly Seaton, Sheetal Sawant, Andrew Fiore-Gartland (8393499), Sheetal Sawant (13839268), Xiaoying Shen (13839276), Andrew Fiore-Gartland, Nicole Potchen   +21 more
core   +1 more source

Guanylate-Binding Proteins 2 and 5 Exert Broad Antiviral Activity by Inhibiting Furin-Mediated Processing of Viral Envelope Proteins

Cell Reports, 2019
Summary: Guanylate-binding protein (GBP) 5 is an interferon (IFN)-inducible cellular factor reducing HIV-1 infectivity by an incompletely understood mechanism.
Elisabeth Braun, Dominik Hotter, Lennart Koepke, Fabian Zech, Rüdiger Groß, Konstantin M.J. Sparrer, Janis A. Müller, Christian K. Pfaller, Elena Heusinger, Rebecka Wombacher, Kathrin Sutter, Ulf Dittmer, Michael Winkler, Graham Simmons, Martin R. Jakobsen, Karl-Klaus Conzelmann, Stefan Pöhlmann, Jan Münch, Oliver T. Fackler, Frank Kirchhoff, Daniel Sauter   +20 more
doaj   +1 more source

ZDHHC18‐Mediated Palmitoylation of ORF3a Promotes SARS‐CoV‐2 Pathogenesis by Antagonizing TRIM16‐Mediated Ubiquitination and Proteasomal Degradation

Advanced Science, Volume 13, Issue 43, 3 August 2026.
Palmitoylation by ZDHHC18 blocks ORF3a K27‐linked ubiquitination mediated by TRIM16, thereby preventing its proteasomal degradation and strengthening viral pathogenesis. Targeting palmitoylation through a pharmacological inhibitor (2‐BP), a competitive inhibitory peptide (OPIP), or adenovirus‐mediated knockdown of ZDHHC18 expression presents a ...
Sidi Yang, Kun Li, Lihong Liu, Linsen Zeng, Qifeng Deng, Jiacheng Huang, Xiaoran Dong, Xin Wang, Jianwei Liang, Hongchao Liu, Hong Peng, Yuxin Lin, Xiaolu Xie, Yuzhen Ye, Tiefeng Xu, Zhaohuan Wang, Chun‐Mei Li, Deyin Guo   +17 more
wiley   +1 more source

Differential recognition of HIV-stimulated IL-1β and IL-18 secretion through NLR and NAIP signalling in monocyte-derived macrophages.

PLoS Pathogens, 2021
Macrophages are important drivers of pathogenesis and progression to AIDS in HIV infection. The virus in the later phases of the infection is often predominantly macrophage-tropic and this tropism contributes to a chronic inflammatory and immune ...
Kathy Triantafilou, Christopher J K Ward, Magdalena Czubala, Robert G Ferris, Emma Koppe, Curt Haffner, Vincent Piguet, Vipulkumar K Patel, Heather Amrine-Madsen, Louise K Modis, Seth L Masters, Martha Triantafilou   +11 more
doaj   +1 more source

Characterisation of llama antibody fragments able to act as HIV-1 entry inhibitors [PDF]

, 2009
Human immunodeficiency virus type 1 (HIV-1) entry into cells is mediated by the functional envelope spike, which consists of trimers of gp120 bound to gp41.
Forsman, A M M, Forsman, A.M.M.
core  

Survival of the fittest: positive selection of CD4+ T cells expressing a membrane-bound fusion inhibitor following HIV-1 infection [PDF]

, 2010
Although a variety of genetic strategies have been developed to inhibit HIV replication, few direct comparisons of the efficacy of these inhibitors have been carried out.
Stephen E. Braun, Berger Annemarie, John J Rossi, Stephen E Braun, Kimpel, Janine, Conolle Michelle, Annemarie Berger, R Paul Johnson, Schmitz, Jörn E., Qiu Gang, Schmitz Jörn E., Qiu, Gang, John J. Rossi, Dorothee von Laer, Wong Fay Eng, Laer, Dorothee von, Boro Dropulic, Humeau, Laurent M., Humeau Laurent M., Christian Brendel, Conolle, Michelle, Brendel Christian, Michelle Conolle, Laurent M Humeau, Braun, Stephen E., Brendel, Christian, Jörn E Schmitz, Wong, Fay Eng, Janine Kimpel, Gang Qiu, Dropulic Boro, von Laer Dorothee, Berger, Annemarie, Jörn E. Schmitz, R. Paul Johnson, Rossi, John J., Rossi John J., Laurent M. Humeau, Fay Eng Wong, Johnson, R. PauL, Kimpel Janine, Braun Stephen E., Johnson R. Paul, Dropulic, Boro   +43 more
core   +2 more sources

AlphaFold2‐Guided Cyclic Peptide Stabilizer Design to Target Protein–Protein Interactions

Proteins: Structure, Function, and Bioinformatics, Volume 94, Issue 7, Page 1356-1370, July 2026.
ABSTRACT The control and modulation of protein–protein interactions (PPIs) is of central importance for the majority of biological processes and most biomedical applications. Stabilization of PPIs, besides inhibition, is of growing pharmaceutical interest.
Niklas Halbwedl, Martin Zacharias
wiley   +1 more source

Characterisation of subtype C HIV-I envelope glycoproteins and their recognition by llama antibody fragments [PDF]

, 2009
Subtype C HIV-1 is currently responsible for the majority of new infections in the world, particularly in parts of Africa where the adult prevalence rate is as high as 15%.
Koh, W.W.-L.
core  

Bacterial Extracellular Vesicles (BEVs) Derived from Chryseobacterium Inhibit Dengue Virus Infection by Disrupting Its Structural Integrity

Journal of Extracellular Vesicles, Volume 15, Issue 6, June 2026.
This study elucidates a novel antiviral mechanism of bacterial BEVs, which are shown to inactivate viruses by triggering membrane fusion, subsequent lysis and causing structural collapse. This direct virucidal action presents a promising broad‐spectrum strategy against diverse enveloped viruses.
Yaqi Gao, Lijian Zhang, Tianci Zhang, Qiufeng Yao, Ruifang Gao, Yue Wang, Yunpeng Zhao, Tingting Zhou, Jikuai Chen, Xing Zhang, Hao Ren, Yongzhe Zhu, Ping Zhao, Zhongtian Qi, Li Luo, Zhaoling Qin   +15 more
wiley   +1 more source

Surfactant protein D inhibits HIV-1 infection of target cells via interference with gp120-CD4 interaction and modulates pro-inflammatory cytokine production [PDF]

, 2014
© 2014 Pandit et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are ...
Al-Mozaini, MA, Pandit Hrishikesh, Yadav Ajit Kumar, Gopal, S, Idicula-Thomas, S, Uday Kishore (504246), Al-Mozaini Maha Ahmed, Vijay Kulkarni, Himangi Warke, Gopal Sandhya, Asif S Qaseem, Sonawani, A, Kulkarni, V, Warke Himangi, Hrishikesh Pandit, Patil, A, Himangi Warke (504243), Idicula-Thomas Susan, Anushree Patil (600836), Gajbhiye, R, Yadav, AK, Sandhya Gopal (600833), Kulkarni Vijay, Archana Sonawani (413679), Warke, H, Susan Idicula-Thomas, Taruna Madan, Sonawani Archana, Asif S. Qaseem, Maha Ahmed Al-Mozaini, Archana Sonawani, Hrishikesh Pandit (504240), Ajit Kumar Yadav (600834), Rahul Gajbhiye (600837), Qaseem, AS, Madan, T, Madan Taruna, Sandhya Gopal, Ajit Kumar Yadav, Qaseem Asif S., Gajbhiye Rahul, Rahul Gajbhiye, Patil Anushree, Pandit, H, Asif S. Qaseem (600835), Kishore Uday, Anushree Patil, Vijay Kulkarni (600838), Maha Ahmed Al-Mozaini (600839), Kishore, U, Taruna Madan (504241), Susan Idicula-Thomas (318974), Uday Kishore   +52 more
core   +2 more sources