Results 61 to 70 of about 9,575 (175)

Gp120 on HIV-1 Virions Lacks O-Linked Carbohydrate.

PLoS ONE, 2015
As HIV-1-encoded envelope protein traverses the secretory pathway, it may be modified with N- and O-linked carbohydrate. When the gp120s of HIV-1 NL4-3, HIV-1 YU2, HIV-1 Bal, HIV-1 JRFL, and HIV-1 JRCSF were expressed as secreted proteins, the threonine ...
Elizabeth Stansell, Maria Panico, Kevin Canis, Poh-Choo Pang, Laura Bouché, Daniel Binet, Michael-John O'Connor, Elena Chertova, Julian Bess, Jeffrey D Lifson, Stuart M Haslam, Howard R Morris, Ronald C Desrosiers, Anne Dell   +13 more
doaj   +1 more source

Recent Developments in HIV Antivirals: The Prospect of Prophylactic Drugs to Change the Pandemic

Microbial Biotechnology, Volume 19, Issue 2, February 2026.
Replication cycle of HIV‐1. The scheme provides an overview from virus entry over reverse transcription of viral RNA into viral DNA, provirus DNA integration into the host genome, genome expression by transcription and translation, proteolytic processing of the viral polyproteins, viral maturation to viral release from the cell. The various targets for
Harald Brüssow
wiley   +1 more source

HERV‐K TM Subunit Elicits CD8+ T Cell Anergy and Tumor Immune Evasion via Targeting CD3 Coreceptor ε in AML and PDAC

Advanced Science, Volume 13, Issue 1, 5 January 2026.
Novel viral immune checkpoint K‐TM subunit is aberrantly expressed in CD8+ T cells and enriched in sera of cancer patients, inducing CD8+ T cell anergy and eliciting potent tumor immune escape in mouse model. Mechanistically, K‐TM directly targets and induces the phosphorylation of CD3ε receptor.
Mengyuan Li, Shuwen Zheng, Qinyuan Gong, Zhaoxing Wu, Wen Lei, Wanyue Cao, Ping Wang, Xuzhao Zhang, Wenbin Qian, Yun Liang, Ying Lu, Fenglin Li, Qi Zhang, Rongzhen Xu   +13 more
wiley   +1 more source

Membrane topology analysis of HIV-1 envelope glycoprotein gp41

Retrovirology, 2010
Background The gp41 subunit of the HIV-1 envelope glycoprotein (Env) has been widely regarded as a type I transmembrane protein with a single membrane-spanning domain (MSD). An alternative topology model suggested multiple MSDs.
Xiao Dan, Long Yufei, Kondo Naoyuki, Liu Shujun, Iwamoto Aikichi, Matsuda Zene   +5 more
doaj   +1 more source

Assessment of antibody responses against gp41 in HIV-1-infected patients using soluble gp41 fusion proteins and peptides derived from M group consensus envelope

Virology, 2008
Human immunodeficiency virus type 1 (HIV-1) transmembrane glycoprotein gp41 is targeted by broadly-reactive neutralizing antibodies 2F5 and 4E10, making it an attractive target for vaccine development. To better assess immunogenic properties of gp41, we generated five soluble glutathione S-transferase fusion proteins encompassing C-terminal 30, 64, 100,
Penn-Nicholson, Adam, Han, Dong P., Kim, Soon J., Park, Hanna, Ansari, Rais, Montefiori, David C., Cho, Michael W.   +6 more
openaire   +2 more sources

Carbon‐13 Centerband‐Only Detection of EXchange with Dynamic Nuclear Polarization

ChemPhysChem, Volume 27, Issue 2, January 2026.
A combination of dynamic nuclear polarization‐based signal enhancement and cryogenic conditions enables counting of spins in a cluster in proteins using 13C‐Centerband‐Only Detection of EXchange when combined with background correction. Optionally, 13C‐depleted labeling of background spins further improves the method.
Abel Cherian Varkey, Kai Xue, Evgeny Nimerovsky, Stefan Becker, Loren B. Andreas   +4 more
wiley   +1 more source

Chimeric Antigen Receptor T‐Cell Therapy: More Than an Anti‐Cancer Drug

HLA, Volume 107, Issue 1, January 2026.
ABSTRACT Initially, chimeric antigen receptor (CAR) T‐cell therapy was developed to eliminate malignant B cells in haematological B‐cell malignancies by targeting CD19 and B‐cell maturation antigen. This approach achieved notable success, resulting in (malignant) B‐cell depletion and inducing clinical remission in cancer patients.
Hannah C. M. Schenk, Ilse Gille, Carolt Arana, Jordi Rovira, Eduard Palou, Fritz Diekmann, Dave L. Roelen, Mirjam H. M. Heemskerk, Sebastiaan Heidt   +8 more
wiley   +1 more source

Enhancing exposure of HIV-1 neutralization epitopes through mutations in gp41.

PLoS Medicine, 2008
The generation of broadly neutralizing antibodies is a priority in the design of vaccines against HIV-1. Unfortunately, most antibodies to HIV-1 are narrow in their specificity, and a basic understanding of how to develop antibodies with broad ...
Catherine A Blish, Minh-An Nguyen, Julie Overbaugh   +2 more
doaj   +1 more source

Fragment Templates in Molecularly Imprinted Polymer Synthesis: Design Strategies, Critical Factors, and Analytical Applications

Advances in Materials Science and Engineering, Volume 2026, Issue 1, 2026.
The utilization of fragment templates in molecular imprinting polymer (MIP) synthesis attracts significant interest in its potential to create polymers with high specificity in recognizing target molecules. The primary advantage of fragment templates lies in their capacity to extract target molecules by focusing on specific components, thus forming ...
Ezra Calista Hutapea, Diva Dhaifina Mazaya Priana, Driyanti Rahayu, Aliya Nur Hasanah, Mohammad Rezwan Habib   +4 more
wiley   +1 more source

Viremic HIV Infected Individuals with High CD4 T Cells and Functional Envelope Proteins Show Anti-gp41 Antibodies with Unique Specificity and Function

PLoS ONE, 2012
CD4 T-cell decay is variable among HIV-infected individuals. In exceptional cases, CD4 T-cell counts remain stable despite high plasma viremia. HIV envelope glycoprotein (Env) properties, namely tropism, fusion or the ability to induce the NK ligand NKp44L, or host factors that modulate Env cytopathic mechanisms may be modified in such situation.We ...
Curriu, Marta, Fausther-Bovendo, Hughes, Pernas, Maria, Massanella, Marta, Carrillo, Jorge, Cabrera, Cecilia, Lopez-Galindez, Luis Cecilio, Clotet, Bonaventura, Debré, Patrice, Vieillard, Vincent, Blanco, Julià   +10 more
openaire   +8 more sources