Results 71 to 80 of about 4,355,851 (162)
Retrovirology, 2011 Background The third variable loop (V3) of the HIV-1 gp120 surface protein is a major determinant of cellular co-receptor binding. However, HIV-1 can also modulate its tropism through other regions in gp120, such as V1, V2 and C4 regions, as well as in ...
D'Arrigo Roberta +5 more
doaj +1 more source
Evaluation of cellular proteins binding to the transmembrane envelope protein gp41 of HIV-1
, 2015 Das von HIV ausgelöste erwobene Immunschwäche-Syndrom (AIDS) stellt auch heute noch ein Problem dar. Im Jahr 2014 waren laut der Weltgesundheitsorganisation (WHO) 36,9 Millionen Menschen mit HIV infiziert. Heute, 30 Jahre nach der Entdeckung von HIV, gibt es zwar gute therapeutische Ansätze, eine Heilung ist aber bisher nicht in Aussicht.
openaire +2 more sources
Protein Science, Volume 35, Issue 6, June 2026.Abstract Membrane fusion between HIV and host cells requires interaction between the N‐terminal and C‐terminal repeat regions (NHR and CHR) of the gp41 envelope subunit. A deep hydrophobic pocket (HP) on the surface of NHR is considered crucial in this interaction.
Daniel Polo‐Megías +9 more
wiley +1 more source
3 BiotechAbstract This study presents the first label-free impedimetric biosensor for the detection of HIV envelope protein gp41 using antimicrobial peptides (AMPs) as biorecognition receptors. The biosensor interface was enhanced with thiolated polystyrene and gold nanospheres to ensure stable peptide immobilization and resist nonspecific adsorption.
Mehmet Ezer, Zihni Onur Uygun
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Liquid–Liquid Phase Separation in Viral Infection and Immunology
MedComm, Volume 7, Issue 4, April 2026.LLPS organizes viral replication and antiviral immunity. Viruses hijack LLPS to form replication factories and evade immune sensors, while hosts assemble LLPS‐driven signaling hubs (e.g., MAVS, RIG‐I, and SGs) to amplify interferon responses. Targeting these condensate interfaces offers novel therapeutic strategies against infectious diseases ...
Jiuzhi Xu +5 more
wiley +1 more source
Induction of Antibodies Specific for Gp41 of HIV-1 by Gene Gun DNA Vaccination [PDF]
, 2012 All attempts to induce broadly neutralising antibodies such as mAb 2F5 and mAb 4E10 targeting conserved epitopes in the membrane proximal external region (MPER) of the transmembrane envelope (TM) protein gp41 of HIV-1 failed so far.
Behrendt, Rayk +4 more
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Understanding the interplay between HIV-1 diversity, humoral immune responses and viral fitness [PDF]
, 2014 Includes bibliographical references.HIV-1 antibody dependent cell cytotoxicity (ADCC) and neutralizing antibody (nAb) responses are both thought to be important responses to elicit through vaccination.
Bandawe, Gama Petulo
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Gp120 on HIV-1 Virions Lacks O-Linked Carbohydrate.
PLoS ONE, 2015 As HIV-1-encoded envelope protein traverses the secretory pathway, it may be modified with N- and O-linked carbohydrate. When the gp120s of HIV-1 NL4-3, HIV-1 YU2, HIV-1 Bal, HIV-1 JRFL, and HIV-1 JRCSF were expressed as secreted proteins, the threonine ...
Elizabeth Stansell +13 more
doaj +1 more source
Nano‐ and Micro‐Sized Solid Materials Used as Antiviral Agents
Advanced Functional Materials, Volume 36, Issue 26, 30 March 2026.Due to the rise of viral infections in humans and possible viral outbreaks, the use of nano‐ or micro‐sized materials as antiviral agents is rapidly increasing. This review explores their antiviral properties against RNA and DNA viruses, either as a prevention or a treatment tool, by delving into their mechanisms of action and how to properly assess ...
Orfeas‐Evangelos Plastiras +6 more
wiley +1 more source
Small molecules that bind the inner core of gp41 and inhibit HIV envelope-mediated fusion
, 2019 HIV-1 enters cells by membrane fusion, mediated by the trimeric viral envelope glycoprotein gp160, which is processed by a single proteolytic cleavage into stably associated gp120 and gp41.
Chen, Bing +5 more
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