Results 71 to 80 of about 9,575 (175)

The large extracellular loop of CD63 interacts with gp41 of HIV-1 and is essential for establishing the virological synapse

Scientific Reports, 2021
Human immunodeficiency virus type 1 (HIV-1) persists lifelong in infected individuals and has evolved unique strategies in order to evade the immune system. One of these strategies is the direct cell-to-cell spread of HIV-1.
Daniel Ivanusic, Kazimierz Madela, Norbert Bannert, Joachim Denner   +3 more
doaj   +1 more source

Induction of HIV‐Specific T Cell Responses Using αDC1 Pulsed With Conserved HIV‐1 Peptides

Journal of Immunology Research, Volume 2026, Issue 1, 2026.
Despite the effectiveness of antiretroviral therapy (ART) in suppressing HIV‐1 replication and reducing morbidity, viral eradication remains unachievable due to the persistence of latent reservoirs, particularly within memory CD4+ T cells. Dendritic cell (DC)‐based immunotherapeutic approaches have emerged as potential strategies to enhance antigen ...
Laís Teodoro Da Silva, Marina Mazzilli Ortega, Silvia de Jesus Mota, Guilherme Castellani, Dennyson Leandro M. Fonseca, Larissa Danielle Bahls Pinto, Gabriela Justamante Handel Schmitz, Isabela Leite, Theo Leite, Mariana Amelia Monteiro, Sandra Marcia Muxel, Robbie B. Mailliard, Alberto José da Silva Duarte, Telma Miyuki Oshiro, Poorani Gurumallesh Prabu   +14 more
wiley   +1 more source

Nanostructured Electrochemical Sensors for Rapid HIV Detection

Journal of Sensors, Volume 2026, Issue 1, 2026.
Many significant and transmissible diseases, including human immunodeficiency virus (HIV)/acquired immune deficiency syndrome (AIDS), COVID‐19, hepatitis, and influenza, are caused by viruses. The rapid replication ability of these viruses is the primary reason for their widespread transmission, resulting in consequences such as loss of life at both ...
Dharmesh Kumar, Sudheesh K. Shukla, Penny P. Govender, Deepali   +3 more
wiley   +1 more source

Flagellins as Vaccine Adjuvants and Cancer Immunotherapy: Recent Advances and Future Prospects

Immunology, Volume 176, Issue 3, Page 277-303, November 2025.
The figure depicts the role of flagellin in immune cells. Flagellin interacts with TLR5, resulting in the formation of homodimers and the recruitment of MyD88, which activates the IκB and MAPK signalling pathways. This results in the activation of NF‐κB and AP‐1, producing TNF‐α, IL‐6, IL‐8, and IL‐12.
Asma Talukder, Md. Mijanur Rahman, Md. Sifat Rahi, Dean L. Pountney, Ming Q. Wei   +4 more
wiley   +1 more source

Crystal structure of HIV-1 gp41 including both fusion peptide and membrane proximal external regions.

PLoS Pathogens, 2010
The HIV-1 envelope glycoprotein (Env) composed of the receptor binding domain gp120 and the fusion protein subunit gp41 catalyzes virus entry and is a major target for therapeutic intervention and for neutralizing antibodies.
Victor Buzon, Ganesh Natrajan, David Schibli, Felix Campelo, Michael M Kozlov, Winfried Weissenhorn   +5 more
doaj   +1 more source

HIV‐1 viral protein effect on cerebral microvasculature: An in vitro blood–brain barrier model

Physiological Reports, Volume 13, Issue 19, October 2025.
Abstract The central nervous system (CNS) serves as a sanctuary for the Human Immunodeficiency Virus (HIV), which is facilitated by HIV's ability to breach the blood–brain barrier (BBB). BBB dysfunction occurs in the earliest stages of an HIV‐1 infection.
Sinelisiwe Matubatuba, Chontrelle Willemse, Khayelihle Brian Makhathini, Carine Smith, David Fisher, Shireen Mentor   +5 more
wiley   +1 more source

Human complement proteins C3b, C4b, factor H and properdin react with specific sites in gp120 and gp41, the envelope proteins of HIV-1.

Immunobiology, 1995
Recently we reported the basic phenomenon of an interaction between the envelope glycoproteins of HIV-1 gp120 and gp41 and components of the human complement system, i.e. activated C4 (C4b) and activated C3 (C3b) and the complement regulator proteins factor H and properdin. In this study we analyze these interactions in detail.
H, Stoiber, R, Schneider, J, Janatova, M P, Dierich   +3 more
openaire   +2 more sources

Unleashing the Antiviral Potential of Stapled Peptides: A New Frontier in Combating Human Neurotropic Viral Infections

Microbial Biotechnology, Volume 18, Issue 9, September 2025.
Human neurotropic viruses like SARS‐CoV‐2, HSV, HOPV and RSV pose significant risks due to their ability to invade and persist in the nervous system. Stapled peptides represent a promising therapeutic approach with enhanced stability, target affinity and bioavailability, emerging as an effective strategy for neutralising human neurotropic viruses ...
Sanskruti Patil, Rakesh Rahangdale, Mukesh Pasupuleti, Puttur Santhoshkumar, Raghu Chandrashekar Hariharapura   +4 more
wiley   +1 more source

Single mutations in the transmembrane envelope protein abrogate the immunosuppressive property of HIV-1

Retrovirology, 2012
Background The mechanism by which HIV-1 induces AIDS is still unknown. Previously, synthetic peptides corresponding to the conserved immunosuppressive (isu) domain in gp41 of HIV-1 had been shown to inhibit proliferation and to modulate cytokine ...
Morozov Vladimir A, Morozov Alexey V, Semaan Marwan, Denner Joachim   +3 more
doaj   +1 more source

Virus-like particles highly expressing DC-SIGN concentrate trimeric HIV-envelope proteins with noncovalently linked immunoreactive gp120 and gp41 [PDF]

Retrovirology, 2012
Background We have hypothesized that membrane-bound macromolecular HIV-envelope proteins (mHIV-env) as a subunit, with gp120 and gp41 in their innate conformation, can be used as an effective immunogen to elicit broadly neutralizing antibodies (bnAb) against sexually or perinatally transmitted HIV-1.
openaire   +4 more sources