Results 91 to 100 of about 4,355,851 (162)

Induction of HIV‐Specific T Cell Responses Using αDC1 Pulsed With Conserved HIV‐1 Peptides

Journal of Immunology Research, Volume 2026, Issue 1, 2026.
Despite the effectiveness of antiretroviral therapy (ART) in suppressing HIV‐1 replication and reducing morbidity, viral eradication remains unachievable due to the persistence of latent reservoirs, particularly within memory CD4+ T cells. Dendritic cell (DC)‐based immunotherapeutic approaches have emerged as potential strategies to enhance antigen ...
Laís Teodoro Da Silva, Marina Mazzilli Ortega, Silvia de Jesus Mota, Guilherme Castellani, Dennyson Leandro M. Fonseca, Larissa Danielle Bahls Pinto, Gabriela Justamante Handel Schmitz, Isabela Leite, Theo Leite, Mariana Amelia Monteiro, Sandra Marcia Muxel, Robbie B. Mailliard, Alberto José da Silva Duarte, Telma Miyuki Oshiro, Poorani Gurumallesh Prabu   +14 more
wiley   +1 more source

Crystal structure of HIV-1 gp41 including both fusion peptide and membrane proximal external regions.

PLoS Pathogens, 2010
The HIV-1 envelope glycoprotein (Env) composed of the receptor binding domain gp120 and the fusion protein subunit gp41 catalyzes virus entry and is a major target for therapeutic intervention and for neutralizing antibodies.
Victor Buzon, Ganesh Natrajan, David Schibli, Felix Campelo, Michael M Kozlov, Winfried Weissenhorn   +5 more
doaj   +1 more source

Human complement proteins C3b, C4b, factor H and properdin react with specific sites in gp120 and gp41, the envelope proteins of HIV-1.

Immunobiology, 1995
Recently we reported the basic phenomenon of an interaction between the envelope glycoproteins of HIV-1 gp120 and gp41 and components of the human complement system, i.e. activated C4 (C4b) and activated C3 (C3b) and the complement regulator proteins factor H and properdin. In this study we analyze these interactions in detail.
H, Stoiber, R, Schneider, J, Janatova, M P, Dierich   +3 more
openaire   +2 more sources

Nanostructured Electrochemical Sensors for Rapid HIV Detection

Journal of Sensors, Volume 2026, Issue 1, 2026.
Many significant and transmissible diseases, including human immunodeficiency virus (HIV)/acquired immune deficiency syndrome (AIDS), COVID‐19, hepatitis, and influenza, are caused by viruses. The rapid replication ability of these viruses is the primary reason for their widespread transmission, resulting in consequences such as loss of life at both ...
Dharmesh Kumar, Sudheesh K. Shukla, Penny P. Govender, Deepali   +3 more
wiley   +1 more source

Virus-like particles highly expressing DC-SIGN concentrate trimeric HIV-envelope proteins with noncovalently linked immunoreactive gp120 and gp41 [PDF]

Retrovirology, 2012
Background We have hypothesized that membrane-bound macromolecular HIV-envelope proteins (mHIV-env) as a subunit, with gp120 and gp41 in their innate conformation, can be used as an effective immunogen to elicit broadly neutralizing antibodies (bnAb) against sexually or perinatally transmitted HIV-1.
openaire   +4 more sources

Single mutations in the transmembrane envelope protein abrogate the immunosuppressive property of HIV-1

Retrovirology, 2012
Background The mechanism by which HIV-1 induces AIDS is still unknown. Previously, synthetic peptides corresponding to the conserved immunosuppressive (isu) domain in gp41 of HIV-1 had been shown to inhibit proliferation and to modulate cytokine ...
Morozov Vladimir A, Morozov Alexey V, Semaan Marwan, Denner Joachim   +3 more
doaj   +1 more source

Recruitment of HIV-1 envelope occurs subsequent to lipid mixing: a fluorescence microscopic evidence

Retrovirology, 2009
Entry of the human immunodeficiency virus (HIV) into the target cell is initiated by fusion with the cell membrane, mediated through the envelope glycoproteins gp120 and gp41, following engagement to CD4 and the co-receptor.
Lin Chi-Hui, Chien Miao-Ping, Chang Ding-Kwo   +2 more
doaj   +1 more source

In Vivo Emergence of HIV-1 Highly Sensitive to Neutralizing Antibodies [PDF]

, 2011
Background: The rapid and continual viral escape from neutralizing antibodies is well documented in HIV-1 infection. Here we report in vivo emergence of viruses with heightened sensitivity to neutralizing antibodies, sometimes paralleling the development
O'Farrell Stephen, Pellegrino, P, Williams Ian, Williams, IG, Kelly M Cheney, Áine McKnight, Anna Forsman, Cheney, Kelly M, McKnight, Áine, Cheney Kelly M., Hué, Stéphane, Forsman Anna, Marlén M I Aasa-Chapman, McKnight, A, Marlén M. I. Aasa-Chapman, Ian Williams, Aasa-Chapman, Marlén MI, Cheney, KM, O'Farrell, S, Stéphane Hué, Kelly M. Cheney, Pellegrino, Pierre, Stephen O'Farrell, Forsman, A, O'Farrell, Stephen, Pierre Pellegrino, Williams, Ian, Forsman, Anna, Aasa-Chapman Marlén M. I., Aasa-Chapman, MMI, Hué Stéphane, McKnight Áine, Pellegrino Pierre, Williams, I, Hue, S, Aasa-Chapman, MM   +35 more
core   +1 more source

Initial antibodies binding to HIV-1 gp41 in acutely infected subjects are polyreactive and highly mutated [PDF]

, 2011
The initial antibody response to HIV-1 is targeted to envelope (Env) gp41, and is nonneutralizing and ineffective in controlling viremia. To understand the origins and characteristics of gp41-binding antibodies produced shortly after HIV-1 transmission ...
Sonya L. Heath, Michael Egholm, Chen, Xi, Simen, Birgitte B, Bar, Katharine J, Haynes, Barton F, Denny, Thomas N, George C. Shaw, Boyd, Scott D, Boyd, Scott D., Egholm, Michael, S. Munir Alam, Eleanor Marshal, Zhang, Ruijun, Shaw, George C, Liao, Hua-Xin, Denny, Thomas N., Scott D. Boyd, Moody, M. Anthony, Xiaozhi Lu, Georgia D. Tomaras, Kepler, Thomas B, Marshall, Dawn J., Lu, Xiaozhi, Bar, Katharine J., Voss, Gerald, Xi Chen, Yu, Jae-Sung, Ruijun Zhang, Paul A. Goepfert, Munshaw, Supriya, Whitesides, John F, Thomas N. Denny, Shaw, George C., Gerald Voss, Alam, S Munir, Hwang, Kwan Ki, Feng Gao, Garnett Kelsoe, Montefiori, David C, Fire, Andrew Z., M. Anthony Moody, Goepfert, Paul A., Goepfert, Paul A, Heath, Sonya L., Simen, Birgitte B., Kelsoe, Garnett, Nathan Vandergrift, Kepler, Thomas B., Fire, Andrew Z, David C. Montefiori, Heath, Sonya L, Markowitz, Martin, Supriya Munshaw, Barton F. Haynes, Yu, Jae Sung, Andrew Z. Fire, Hwang, Kwan-Ki, Birgitte B. Simen, Thomas B. Kepler, Katharine J. Bar, Moody, M Anthony, Kwan-Ki Hwang, Gao, Feng, Whitesides, John F., Margolis, David M., Dawn J. Marshall, Marshall, Dawn J, David M. Margolis, Liao, Hua Xin, Marshal, Eleanor, Tomaras, Georgia D., John F. Whitesides, Hua-Xin Liao, Jae-Sung Yu, Alam, S. Munir, Martin Markowitz, Tomaras, Georgia D, Hanczaruk, Bozena, Montefiori, David C., Margolis, David M, Bozena Hanczaruk, Vandergrift, Nathan, Haynes, Barton F.   +83 more
core   +1 more source

Role of Human Immunodeficiency Virus (HIV) Type 1 Envelope in the Anti-HIV Activity of the Betulinic Acid Derivative IC9564 [PDF]

, 2001
The betulinic acid derivative IC9564 is a potent anti-human immunodeficiency virus (anti-HIV) compound that can inhibit both HIV primary isolates and laboratory-adapted strains.
Chin Ho Chen, Holz-Smith, S. L., Thomas J. Matthews, Kuo-Hsiung Lee, Lei Jin, Lee, K.-H., I-Chen Sun, Matthews, T. J., Jin, L., Sonia L. Holz-Smith, Chen, C. H., Sun, I-C.   +11 more
core   +1 more source