Results 111 to 120 of about 4,355,851 (162)

Definition of an immunodominant T cell epitope contained in the envelope gp41 sequence of HIV-1

, 1992
SUMMARY The majority of the immunodominant amino acid sequences of HIV-I that have been characterized to date are coded for by hypervariable gene sequences.
D A COOPER, S J D BELL, R PENNY, R R DOHERTY, B E KEMP   +4 more
core   +1 more source

Membrane Structure Correlates to Function of LLP2 on the Cytoplasmic Tail of HIV-1 GP41 Protein

, 2018
Mutation studies previously showed that the lentivirus lytic peptide (LLP2) sequence of the cytoplasmic C-terminal tail of the HIV-1 gp41 envelope protein inhibited viral-initiated T-cell death and T-cell syncytium formation, at which time in the HIV ...
Jonathan D. Steckbeck (43112), Stephanie Tristram-Nagle (3894544), Jonathan Michel (5387507), Michael Jablin (5387498), Alexander Boscia (5387504), John F. Nagle (1964512), Zachary Benamram (5387501), Ronald C. Montelaro (178872)   +7 more
core   +1 more source

Correction: Effects of the I559P gp41 Change on the Conformation and Function of the Human Immunodeficiency Virus (HIV-1) Membrane Envelope Glycoprotein Trimer

, 2015
Correction: Effects of the I559P gp41 Change on the Conformation and Function of the Human Immunodeficiency Virus (HIV-1) Membrane Envelope Glycoprotein ...
PLOS ONE (2189197)
core   +1 more source

Recombinant E2₃₄₀-Fc protein and E2-derived peptides bind HIV-1 gp41.

, 2013
(A) 293T cells expressing NL4-3 envelope (X4env) or empty plasmid as control were incubated with sCD4 and FITC-conjugated E2 peptides, respectively. Peptide binding was analyzed by flow cytometry.
Bernhard Fleckenstein (275876), Kristin Eissmann (275869), Heinrich Sticht (173676), Heide Reil (275877), Peng Zou (275872), Shibo Jiang (275873), Sebastian Mueller (275870), Jutta Eichler (275875), Andrea Gross (275874), Susan Jung (275871)   +9 more
core   +1 more source

Stable expression of HIV-1 MPER extended epitope on the surface of the recombinant probiotic bacteria Escherichia Coli Nissle 1917 using CRISPR/Cas9

Microbial Cell Factories
Background Mucosal vaccines have the potential to induce protective immune responses at the sites of infection. Applying CRISPR/Cas9 editing, we aimed to develop a probiotic-based vaccine candidate expressing the HIV-1 envelope membrane-proximal external
Nathaniel Ninyio, Katharina Schmitt, Gladys Sergon, Charlotta Nilsson, Sören Andersson, Nikolai Scherbak   +5 more
doaj   +1 more source

Using a Drug Repurposing Strategy to Virtually Screen Potential HIV-1 Entry Inhibitors That Block the NHR Domain of the Viral Envelope Protein gp41

Mathematical Biology and Bioinformatics
Using a drug repurposing strategy, virtual screening of potential inhibitors of the NHR domain of the HIV-1 gp41 protein, a conserved region critical for the virus-cell membrane fusion and viral infectivity, was carried out. The used computational approach included: (1) molecular docking of this functionally significant region of the HIV-1 envelope ...
A.M. Andrianov, Y.V. Laykov, A.V. Tuzikov   +2 more
openaire   +1 more source

Model for the structure of the HIV gp41 ectodomain: insight into the intermolecular interactions of the gp41 loop

, 2001
In human immunodeficiency virus (HIV) the viral envelope proteins gp41 and gp120 form a non-covalent complex, which is a potential target for AIDS therapies. In addition gp41 plays a possible role in HIV infection of B cells via the complement system. In
Caffrey, Michael
core   +1 more source

Characterization and epitope mapping of KI-41, a murine monoclonal antibody specific for the gp41 envelope protein of the human immunodeficiency virus-1

, 1998
In this study, a mouse monoclonal antibody (mAb) against gp41(584-618), the immunodominant epitope of HIV-1 gp41 envelope protein, was generated. For this purpose, BALB/c mice were immunized with double branched multiple antigenic peptides derived from ...
Myung Kyu Lee, Kyung Soo Hahm, Song Yub Shin, So Youn Jang, Jung Hyun Park   +4 more
core  

Targeted expression of the anti-HIV microbicide lectin griffithsin in maize and tobacco [PDF]

, 2013
Includes abstract.Includes bibliographical references.Plants are emerging as cost friendly alternative production systems for a variety of pharmaceuticals. Numerous therapeutic proteins have been produced in plant systems (Giddings et al., 2000; Ma et al.
Stark, Hester Catharina (Therese)
core   +1 more source

HIV Envelope Protein gp41 [PDF]

, 2020
openaire   +1 more source