Results 121 to 130 of about 4,355,851 (162)

Plant Lectin, MoMo30, Pressures HIV-1 to Select for Variants with Deleted N-Linked Glycosylation Sites

Viruses
Momordica balsamina, a plant traditionally used in African medicine, contains a 30 kDa protein, MoMo30, previously identified by our group as an anti-HIV agent that binds glycan residues on the gp120 envelope protein, thereby acting as an entry inhibitor.
Morgan I. Coleman, Mahfuz B. Khan, Erick Gbodossou, Amad Diop, Kenya DeBarros, Vincent C. Bond, Virginia Floyd, Kofi Kondwani, Valerie Montgomery Rice, Michael D. Powell   +9 more
doaj   +1 more source

J3ExoA: A Novel Anti-HIV Immunotoxin Fusion of Anti-Gp120 J3VHH and PE38 Fragment of Pseudomonas Exotoxin A

Pharmaceuticals
Background. We are developing cytotoxic anti-HIV immunoconjugates to attack the reservoir of infected cells that persist after years of fully suppressive anti-retroviral therapy. Methods.
Seth H. Pincus, Kun Luo, Tami Peters, James T. Gordy, Frances M. Cole, Grant Klug, Kelli Ober, Tamera K. Marcotte, Richard B. Markham   +8 more
doaj   +1 more source

Antigenicity and immunogenicity of the membrane proximal external region of the HIV-1 envelope protein gp41

, 2007
Two of the six HIV-1 broadly neutralizing monoclonal antibody (bNt MAbs) isolated so far bind epitopes located in the viral envelope protein gp41. 2F5 and 4E10 neutralize viruses from a broad range of different isolates. Although gp41 is a transmembrane protein, the study of its antigenicity and immunogenicity in the context of membrane has been ...
openaire   +1 more source

[Comparison of the diagnostic value of recombinant antigens and synthetic peptides that mimic the immunogenic epitopes of the envelop protein gp41 in the enzyme immunodetection of HIV-1 antibodies].

Voprosy virusologii, 2006
The study was undertaken to comparatively examine the efficiency of HIV antibody detection by enzyme immunoassay using recombinant antigens and synthetic peptides containing the most immunodominant region of the human immunodeficiency virus envelop protein gp41-cytotoxic T-lymphocytic (CTL) epitope.
E N, Baranova, V F, Puzyrev, O E, Van'kova, V K, Pimenov, A N, Burkov, A P, Obriadina, T I, Ulanova   +6 more
openaire   +1 more source

Antibody-dependent enhancement of HIV-1 infection. [PDF]

, 2007
Antibody-dependent enhancement (ADE) is the process by which virus-specific antibodies enhance entry or replication of a virus, leading to increased infection and the potential to exacerbate disease progression or severity. In terms of HIV infection, ADE
Willey, S., Willey, Suzanne
core  

HIV GP41 Envelope Protein Early and Late Membrane Fusion Stages are Impaired by a Sphinganine Based Lipo-Peptide [PDF]

Biophysical Journal, 2018
Yoel A. Klug, Avraham Ashkenazi, Mathias Viard, Ziv Porat, Robert Blumenthal, Yechiel Shai   +5 more
openaire   +1 more source

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An Approach for an Immunoaffinity AIDS Sensor Using the Conservative Region of the HIV Envelope Protein (gp41) and Its Monoclonal Antibody

Biosensors and Bioelectronics, 1995
A monoclonal antibody for the conservative region of gp41, which is one of the HIV envelope proteins, was produced. The antigen determining site of gp41 was examined using the epitope mapping technique, followed by an enzyme linked immunosorbent assay. Some peptides had comparable affinities for the monoclonal antibody, but the peptide EGIEE, having a ...
Taizo Uda, Emi Hifumi, Tetsutarō Sata
exaly   +3 more sources

Analysis of the Interaction Between the HIV-Inactivating Protein Cyanovirin-N and Soluble Forms of the Envelope Glycoproteins gp120 and gp41

Molecular Pharmacology, 2000
The novel virucidal protein cyanovirin-N (CV-N) binds with equally high affinity to soluble forms of either H9 cell-produced or recombinant glycosylated HIV-1 gp120 (sgp120) or gp160 (sgp160). Fluorescence polarization studies showed that CV-N is also capable of binding to the glycosylated ectodomain of the HIV-envelope protein gp41 (sgp41) (as well as
Barry R O'Keefe, Shilpa R Shenoy, Michael R Boyd   +2 more
exaly   +3 more sources

Conformational Study of Fragments of Envelope Proteins (gp120: 254–274 And gp41: 519–541) Of HIV-1 by NMR and MD Simulations

Journal of Peptide Science, 2004
AbstractThe envelope proteins, gp120 and gp41 of HIV‐1, play a crucial role in receptor (CD4+ lymphocytes) binding and membrane fusion. The fragment 254–274 of gp120 is conserved in all strains of HIV and, as a part of the full gp120 protein, behaves as ‘immunosilent’, but as an individual fragment it is ‘immunoreactive’.
Meena Kanyalkar, Evans C. Coutinho, Anil Saran   +2 more
exaly   +3 more sources

Detection of antibodies to p24 and gp41 epitopes of HIV by ELISA using the recombinant core protein (p24) and envelope synthetic protein (gp41).

Microbiologica, 1991
We have developed a system consisting of two separate ELISA, one designed to detect antibodies to HIV gag gene (p24) and the other to detect antibodies to HIV env gene (gp41). The antigen used in these ELISA was produced as recombinant DNA-derived proteins expressed in E.
FILICE, GAETANO, Soldini L., ORSOLINI, PAOLO, Razzini E., Chiapparoli L., GUlminetti R., Cattaneo E., Achilli G.   +7 more
openaire   +2 more sources