Results 141 to 150 of about 9,575 (175)

Analysis of the Interaction between the HIV-Inactivating Protein Cyanovirin-N and Soluble Forms of the Envelope Glycoproteins gp120 and gp41

Molecular Pharmacology, 2000
The novel virucidal protein cyanovirin-N (CV-N) binds with equally high affinity to soluble forms of either H9 cell-produced or recombinant glycosylated HIV-1 gp120 (sgp120) or gp160 (sgp160). Fluorescence polarization studies showed that CV-N is also capable of binding to the glycosylated ectodomain of the HIV-envelope protein gp41 (sgp41) (as well as
Barry O'Keefe
exaly   +3 more sources

Interaction of several complement proteins with gp120 and gp41, the two envelope gycoproteins of HIV-1

AIDS, 1995
To study the binding of human complement proteins to gp41 and gp120 of HIV-1.The interaction of complement proteins with gp41 and gp120 and their effect on the gp41-gp120 complex in enzyme-linked immunosorbent assays (ELISA) and on stably transfected Schneider-2 cells expressing a gp41-gp120 complex was investigated.
H, Stoiber, C, Ebenbichler, R, Schneider, J, Janatova, M P, Dierich   +4 more
openaire   +2 more sources

Antibody-dependent cellular cytotoxicity is directed against both the gp120 and gp41 envelope proteins of HIV

Aids, 1989
To define the target antigens for antibody-dependent cellular cytotoxicity (ADCC), assays were performed using affinity-purified human immunoglobulin (Ig) or polyclonal rabbit sera directed against specific proteins of HIV. ADCC was not found using affinity-purified anti-core (p25) human Ig or sera obtained from rabbits hyper-immunized with recombinant
L A, Evans, G, Thomson-Honnebier, K, Steimer, E, Paoletti, M E, Perkus, H, Hollander, J A, Levy   +6 more
openaire   +2 more sources

Theoretically Determined Three-Dimensional Structures for Amphipathic Segments of the HIV-1 gp41 Envelope Protein

AIDS Research and Human Retroviruses, 1989
Three-dimensional computer models for two segments of the C terminus of gp41, the transmembrane AIDS envelope protein, which may form amphipathic α-helices, have been generated using structure prediction techniques combined with energy minimization and molecular dynamics simulations.
R M, Venable, R W, Pastor, B R, Brooks, F W, Carson   +3 more
openaire   +2 more sources

HIV-1 envelope protein gp41 modulates expression of interleukin-10 and chemokine receptors on monocytes, astrocytes and neurones

AIDS, 2000
To analyse the effect of HIV-1 transmembrane protein gp41 on cytokine production and chemokine receptor expression in blood and brain.Because previous results had demonstrated that recombinant gp41 contributes to HIV-induced dysfunction of blood immune cells we investigated its effect on interleukin (IL)-10 synthesis and expression of the HIV ...
C, Speth, B, Joebstl, M, Barcova, M P, Dierich   +3 more
openaire   +2 more sources

[Towards a vaccine for HIV infection: role of the gp41 envelope protein].

Bulletin de l'Academie nationale de medecine, 2009
HIV infection leads to a gradual deterioration in immune status. The mechanisms underlying CD4 T cell depletion in this setting are controversial. One of the most intriguing phenomena is that many uninfected CD4 cells die prematurely in HIV-infected subjects. We therefore investigated the possibility that these cells are killed by a collateral effector
Patrice, Debre, Dominique, Costagliola, Roger, Legrand, Vincent, Vieillard   +3 more
openaire   +1 more source

Interaction of a basic amphipathic peptide from the carboxyterminal part of the HIV envelope protein gp41 with negatively charged lipid surfaces

Chemistry and Physics of Lipids, 1998
The interaction of the positively charged synthetic amphipathic peptide fragment gp41(828) corresponding to a segment from the carboxyterminal region of the HIV envelope glycoprotein gp41 with lipid monolayers spread at the air-water interface has been studied by film balance measurements.
D, Trommeshauser, H J, Galla
openaire   +2 more sources

Detection of antibodies to p24 and gp41 epitopes of HIV by ELISA using the recombinant core protein (p24) and envelope synthetic protein (gp41).

Microbiologica, 1991
We have developed a system consisting of two separate ELISA, one designed to detect antibodies to HIV gag gene (p24) and the other to detect antibodies to HIV env gene (gp41). The antigen used in these ELISA was produced as recombinant DNA-derived proteins expressed in E.
FILICE, GAETANO, Soldini L., ORSOLINI, PAOLO, Razzini E., Chiapparoli L., GUlminetti R., Cattaneo E., Achilli G.   +7 more
openaire   +1 more source

Conformational study of fragments of envelope proteins (gp120: 254–274 and gp41: 519–541) of HIV‐1 by NMR and MD simulations

Journal of Peptide Science, 2004
AbstractThe envelope proteins, gp120 and gp41 of HIV‐1, play a crucial role in receptor (CD4+ lymphocytes) binding and membrane fusion. The fragment 254–274 of gp120 is conserved in all strains of HIV and, as a part of the full gp120 protein, behaves as ‘immunosilent’, but as an individual fragment it is ‘immunoreactive’.
Meena, Kanyalkar, Sudha, Srivastava, Anil, Saran, Evans, Coutinho   +3 more
openaire   +2 more sources

Class I-restricted presentation of an HIV-1 gp41 epitope containing an N-linked glycosylation site. Implications for the mechanism of processing of viral envelope proteins

The Journal of Immunology, 1996
Abstract Uncertainty exists over the site of processing of viral envelope (env) proteins for recognition by CTL. The extracellular domains of env proteins are not present in the cytosol, the site where the class I Ag processing pathway begins.
R L, Ferris, C, Buck, S A, Hammond, A S, Woods, R J, Cotter, M, Takiguchi, Y, Igarashi, Y, Ichikawa, R F, Siliciano   +8 more
openaire   +2 more sources