Results 101 to 110 of about 4,355,851 (162)

A stabilized HIV-1 envelope glycoprotein trimer fused to CD40 ligand targets and activates dendritic cells

Retrovirology, 2011
Background One reason why subunit protein and DNA vaccines are often less immunogenic than live-attenuated and whole-inactivated virus vaccines is that they lack the co-stimulatory signals provided by various components of the more complex vaccines.
Berkhout Ben, David Kathryn, van de Sandt Carolien, Bontjer Ilja, van Montfort Thijs, Eggink Dirk, de Vries Robert P, Matthews Katie, Melchers Mark, Moore John P, Sanders Rogier W   +10 more
doaj   +1 more source

Studies of HIV gp160 Envelope Protein Structure: Molecular Modeling of gp41 C-terminus

, 2015
The membrane proximal region, membrane spanning domain and C-terminus region of HIV gp41 are highly conserved and essential mechanisms for cell membrane fusion and entry. Multiple resolved structures exist for the membrane distal gp120, however little is
Gamble, Reid
core  

A modification to heptad repeat 1 of gp41 improves yield and/or quality of soluble pre-fusion HIV-1 envelope glycoprotein trimers

Journal of Virology
Native-like HIV-1 envelope glycoprotein (Env) trimers, exemplified by the SOSIP design, are widely used as immunogens, analytical antigens, and for structural studies.
Devidas N. Chaturbhuj, Kwinten Sliepen, Albert Cupo, Benjamin Steinberg, Simon Kazimierczyk, Tarek Munawar, Kyle Kramer, Anila Yasmeen, Thales G. Andrade, Wen-Hsin Lee, Lara van der Maas, Grace Gibson, Oscar Feliciano, Ivan del Moral Sanchez, Edith Schermer, Rhianna Bronson, Alison Benner, Madhu Prabhakaran, Rosemarie Mason, P. J. Klasse, Andrew B. Ward, Gabriel Ozorowski, Rogier W. Sanders, John P. Moore   +23 more
doaj   +1 more source

Increased titers of neutralizing antibodies after immunization with both envelope proteins of the porcine endogenous retroviruses (PERVs)

Virology Journal, 2012
Despite enormous difficulties to induce antibodies neutralizing HIV-1, especially broadly neutralizing antibodies directed against the conserved membrane proximal external region (MPER) of the transmembrane envelope protein, such antibodies can be easily
Denner Joachim, Mihica Debora, Kaulitz Danny, Schmidt Christa-Maria   +3 more
doaj   +1 more source

Protein Design of an HIV-1 Entry Inhibitor

, 2001
Human immunodeficiency virus type–1 (HIV-1) membrane fusion is promoted by the formation of a trimer-of-hairpins structure that brings the amino- and carboxyl-terminal regions of the gp41 envelope glycoprotein ectodomain into close proximity.
Peter S. Kim, Michael S. Kay, Michael J. Root   +2 more
core   +1 more source

Conformational Heterogeneity of the HIV Envelope Glycan Shield

Scientific Reports, 2017
To better understand the conformational properties of the glycan shield covering the surface of the HIV gp120/gp41 envelope (Env) trimer, and how the glycan shield impacts the accessibility of the underlying protein surface, we performed enhanced ...
Mingjun Yang, Jing Huang, Raphael Simon, Lai-Xi Wang, Alexander D. MacKerell   +4 more
doaj   +1 more source

HIV-1 Structural Proteins or Cell-Signaling Factors? That Is the Question!

Current Issues in Molecular Biology
The biological activity of structural HIV-1 proteins is not limited to ensuring a productive viral infection but also interferes with cellular homeostasis through intra- and extracellular signaling activation.
Michele Pellegrino, Francesca Giordano, Francesca De Amicis, Maria Marra, Paola Tucci, Stefania Marsico, Stefano Aquaro   +6 more
doaj   +1 more source

Human Antibodies that Recognize Novel Immunodominant Quaternary Epitopes on the HIV-1 Env Protein.

PLoS ONE, 2016
Numerous broadly neutralizing antibodies (Abs) target epitopes that are formed or enhanced during mature HIV envelope formation (i.e. quaternary epitopes).
Mark D Hicar, Xuemin Chen, Chidananda Sulli, Trevor Barnes, Jason Goodman, Hakimuddin Sojar, Bryan Briney, Jordan Willis, Valentine U Chukwuma, Spyros A Kalams, Benjamin J Doranz, Paul Spearman, James E Crowe   +12 more
doaj   +1 more source

Abstracts From AIDS 2026, the 26th International AIDS Conference, 26 – 31 July 2026 Rio de Janeiro, Brazil & virtual

Journal of the International AIDS Society, Volume 29, Issue S4, July 2026.
wiley   +1 more source

Identification of a human protein-derived HIV-1 fusion inhibitor targeting the gp41 fusion core structure.

, 2013
The HIV-1 envelope glycoprotein (Env) gp41 plays a crucial role in the viral fusion process. The peptides derived from the C-terminal heptad repeat (CHR) of gp41 are potent HIV fusion inhibitors. However, the activity of these anti-HIV-1 peptides in vivo
Lijun Chao, Xiaowen Yu, Lu Lu, Yun Zhu, Ying-Hua Chen, Hengwen Yang, Qian Wang, Yuan Li, Shibo Jiang   +8 more
core   +1 more source