Results 131 to 140 of about 24,285 (259)

Prediction and validation of HIV-1 gp41 ecto-transmembrane domain post-fusion trimeric structure using molecular modeling

, 2019
The glycoproteins on the surface of human immunodeficiency virus (HIV) undergoes cascade of conformational transitions to evade the human immune system.
Maiti, Prabal K, Maiti, Prabal K., Gorai, Biswajit, Das, Satyabrata   +3 more
core   +1 more source

Abstracts From AIDS 2026, the 26th International AIDS Conference, 26 – 31 July 2026 Rio de Janeiro, Brazil & virtual

Journal of the International AIDS Society, Volume 29, Issue S4, July 2026.
wiley   +1 more source

Refolding Dynamics of gp41 from Pre-fusion to Pre-hairpin States during HIV‑1 Entry

, 2019
The HIV-1 infection is triggered by the binding of the viral envelope glycoprotein (Env) gp120–gp41 trimer to host-cell receptor CD4 and co-receptor CCR5/CXCR4, which leads to substantial conformational changes of Env, that is, structural transition of ...
Mengna Lin (8202051), Lin-Tai Da (399373)   +1 more
core   +1 more source

Computational study of bindings of olive leaf extract (OLE) to HIV-1 fusion protein gp41

, 2007
Recent experimental study found that OLE (olive leaf extract) has anti-HIV activity by blocking the HIV virus entry to host cells [Lee-Huang, S., Zhang, L., Huang, P.L., Chang, Y. and Huang, P.L.
Zhang, J.Z.H., Huang, P. Lin, P. Lin Huang, Lee-Huang, S., Zhang, D.W., S. Lee-Huang, J.Z.H. Zhang, P. Lee Huang, Bao, J., J. Bao, Huang, P. Lee, D.W. Zhang   +11 more
core   +1 more source

Studies on the mechanism of complement-mediated inhibition of antibody binding to HIV gp41

, 1993
SUMMARY We have previously demonstrated that HIV envelope gp41 binding to specific antibodies decreases after preincubation of fluid-phase gp41 in normal human serum.
G ARLAUD, N M THIELENS, Z PROHÁSZKA, M P DIERICH, T HIDVÉGI, K NAGY, E UJHELYI, H HAMPL, G FÜST   +8 more
core   +1 more source

HIV-1 Entry Inhibitors: A Review of Structure-Based Drug Design Targeting the Conserved Hydrophobic Pocket of gp41

, 2016
This paper reviews two principle approaches to inhibition of gp41-mediated membrane fusion: peptide and small molecule structure-based drug design. In particular, I explore the methods, challenges, and findings of structural studies of gp41, as well as ...
Weber, Lindsey Catherine
core   +1 more source

Structural Studies of Computationally Designed Inhibitors of HIV Gp41 [PDF]

, 2016
Human immunodeficiency virus (HIV) infection is a major public health concern. New strategies that target viral entry hold promise for preventing infection or for enhancing the efficacy of existing anti-retroviral therapy.
Madzelan, Peter, Paudel, Abi, Rizzo, Robert C., Allen, William J., Wilson, Mark A.   +4 more
core  

Conformational trajectory of the HIV-1 fusion peptide during CD4-induced envelope opening

Nature Communications
The hydrophobic fusion peptide (FP), a critical component of the HIV-1 entry machinery, is located at the N terminus of the envelope (Env) gp41 subunit. The receptor-binding gp120 subunit of Env forms a heterodimer with gp41.
Bhishem Thakur, Revansiddha H. Katte, Wang Xu, Katarzyna Janowska, Salam Sammour, Rory Henderson, Maolin Lu, Peter D. Kwong, Priyamvada Acharya   +8 more
doaj   +1 more source

HIV gp41 [PDF]

Science-Business eXchange, 2014
openaire   +1 more source

Sensitivity and specificity of anti-HIV ELISA employing recombinant (p24, p66, gp120) and synthetic (gp41) viral antigenic peptides

, 1991
We have developed two immunoassay systems, one designated HIV (p24, p66, gp41) ELISA that use as antigens the immunodominant epitopes mixed from each of three major groups of HIV-1 proteins: the core (p24), the pol (p66) and the env (gp41) gene.
FILICE, GAETANO, ORSOLINI, PAOLO, Gulminetti R., Razzini E., Achilli G., Chiapparoli L., Soldini L., Cattaneo E., Campisi D.   +8 more
core