Results 41 to 50 of about 24,285 (259)

Single mutations in the transmembrane envelope protein abrogate the immunosuppressive property of HIV-1

Retrovirology, 2012
Background The mechanism by which HIV-1 induces AIDS is still unknown. Previously, synthetic peptides corresponding to the conserved immunosuppressive (isu) domain in gp41 of HIV-1 had been shown to inhibit proliferation and to modulate cytokine ...
Morozov Vladimir A, Morozov Alexey V, Semaan Marwan, Denner Joachim   +3 more
doaj   +1 more source

Antiviral Activities of HIV-1-Specific Human Broadly Neutralizing Antibodies Are Isotype-Dependent

Vaccines, 2022
Broadly neutralizing antibodies (bNAbs) offer promising opportunities for preventing HIV-1 infection. The protection mechanisms of bNAbs involve the Fc domain, as well as their Fab counterpart.
Blandine Noailly, Melyssa Yaugel-Novoa, Justine Werquin, Fabienne Jospin, Daniel Drocourt, Thomas Bourlet, Nicolas Rochereau, Stéphane Paul   +7 more
doaj   +1 more source

Evaluating the neutralizing antibody response to HIV-1 membrane proximal external regional; Implications for vaccine design [PDF]

, 2014
Includes bibliographical references.Inducing broadly neutralizing antibodies targeting the HIV-1 envelope is thought to be crucial for developing an effective vaccine.
Jacob, Rajesh Abraham
core   +1 more source

The Functional Oligomeric State of Tegument Protein GP41 Is Essential for Baculovirus Budded Virion and Occlusion-Derived Virion Assembly

Journal of Virology, 2018
gp41, one of the baculovirus core genes, encodes the only recognized tegument (O-glycosylated) protein of the occlusion-derived virion (ODV) phenotype so far.
Yimeng Li, S. Shěn, Liang-Bo Hu, F. Deng, J. Vlak, Zhi-Hong Hu, Hua-Lin Wang, Man-Li Wang   +7 more
semanticscholar   +1 more source

Trilobatin as an HIV‐1 entry inhibitor targeting the HIV‐1 Gp41 envelope

FEBS Letters, 2018
HIV‐1 transmembrane protein gp41 plays a crucial role by forming a stable six‐helix bundle during HIV entry. Due to highly conserved sequence of gp41, the development of an effective and safe small‐molecule compound targeting gp41 is a good choice ...
Shuwen Yin, Xuanxuan Zhang, Fangyuan Lai, Tai-zhen Liang, Jia-Yong Wen, Wanying Lin, Jia-yin Qiu, Shu-Wen Liu, Lin Li   +8 more
semanticscholar   +1 more source

Increased infectivity in human cells and resistance to antibody-mediated neutralization by truncation of the SIV gp41 cytoplasmic tail

Frontiers in Microbiology, 2013
The role of antibodies in protecting the host from human immunodeficiency virus type 1 (HIV-1) infection is of considerable interest, particularly because the RV144 trial results suggest that antibodies contribute to protection.
Takeo eKuwata, Kaori eTakaki, Ikumi eEnomoto, Kazuhisa eYoshimura, Shuzo eMatsushita   +4 more
doaj   +1 more source

The membrane-spanning domain of gp41 plays a critical role in intracellular trafficking of the HIV envelope protein

Retrovirology, 2010
Background The sequences of membrane-spanning domains (MSDs) on the gp41 subunit are highly conserved among many isolates of HIV-1. The GXXXG motif, a potential helix-helix interaction motif, and an arginine residue (rare in hydrophobic MSDs) are ...
Kondo Naoyuki, Long Yufei, Curran A Rachael, Miyauchi Kosuke, Iwamoto Aikichi, Engelman Donald M, Matsuda Zene   +6 more
doaj   +1 more source

Structure, membrane topology and influence of cholesterol of the membrane proximal region: transmembrane helical anchor sequence of gp41 from HIV

Scientific Reports, 2020
During the first steps of HIV infection the Env subunit gp41 is thought to establish contact between the membranes and to be the main driver of fusion.
Christopher Aisenbrey, Omar Rifi, Burkhard Bechinger   +2 more
doaj   +1 more source

Initiation of immune tolerance–controlled HIV gp41 neutralizing B cell lineages

Science Translational Medicine, 2016
Immune tolerance mechanisms limit gp41 neutralizing antibody lineage maturation to broadly neutralizing antibodies. An immune block to HIV vaccines Because HIV is a rapidly mutating virus, a successful vaccine will need to elicit an immune response ...
Rui-Jun Zhang, Laurent Verkoczy, K. Wiehe, S. Alam, N. Nicely, S. Santra, Todd Bradley, Charles W. Pemble, Jinsong Zhang, Feng Gao, D. Montefiori, H. Bouton-Verville, G. Kelsoe, K. Larimore, P. Greenberg, Robert Parks, A. Foulger, Jessica N. Peel, Kan Luo, Xiao-Zhi Lu, A. Trama, N. Vandergrift, G. Tomaras, T. Kepler, M. Moody, H. Liao, B. Haynes   +26 more
semanticscholar   +1 more source

gp41-specific QA255 mAbs mediate ADCC activity.

, 2019
Percent ADCC activity for target cells coated with either (A) clade B MN gp41 protein, (B) clade C ZA.1197 gp41 ectodomain or (C) clade A Q461.e2 TAIV gp140 protein is shown on the y-axis.
Katherine L. Williams (197272), Dani Vézina (6377675), Meghan Garrett (6377669), Katharine Dusenbury (6377678), Julie Overbaugh (53378), Peter S. Kim (49802), Nicole Elise Naiman (6377666), Andrés Finzi (76574), Theodore Gobillot (6377672), Nitya S. Ramadoss (382076), Megan Stumpf (6377663), Shilei Ding (277041), Ryan Basom (4843455)   +12 more
core   +1 more source