Results 41 to 50 of about 13,523 (178)
Receptor Activation of HIV-1 Env Leads to Asymmetric Exposure of the gp41 Trimer.
PLoS Pathogens, 2016 Structural rearrangements of HIV-1 glycoprotein Env promote viral entry through membrane fusion. Env is a symmetric homotrimer with each protomer composed of surface subunit gp120 and transmembrane subunit gp41.
Mukta D Khasnis +3 more
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HIV-1 gp41 and TCRalpha trans-membrane domains share a motif exploited by the HIV virus to modulate T-cell proliferation. [PDF]
PLoS Pathogens, 2010 Viruses have evolved several strategies to modify cellular processes and evade the immune response in order to successfully infect, replicate, and persist in the host.
Tomer Cohen +4 more
doaj +1 more source
Viruses, 2022 Human Immunodeficiency virus (HIV-1) fusion is mediated by glycoprotein-41, a protein that has not been widely exploited as a drug target. Small molecules directed at the gp41 ectodomain have proved to be poorly drug-like, having moderate efficacy, high ...
Li He +6 more
doaj +1 more source
A Role for Baculovirus GP41 in Budded Virus Production
Virology, 1997 Insect cells infected with tsB1074, a temperature-sensitive mutant of Autographa californica nuclear polyhedrosis virus, exhibit a "single-cell-infection" phenotype whereby the infection progresses through the very late phase culminating in occlusion body formation, but neighboring cells do not become infected.
Olszewski, Julie, Miller, Lois K.
openaire +2 more sources
Identification of a human protein-derived HIV-1 fusion inhibitor targeting the gp41 fusion core structure. [PDF]
PLoS ONE, 2013 The HIV-1 envelope glycoprotein (Env) gp41 plays a crucial role in the viral fusion process. The peptides derived from the C-terminal heptad repeat (CHR) of gp41 are potent HIV fusion inhibitors. However, the activity of these anti-HIV-1 peptides in vivo
Lijun Chao +8 more
doaj +1 more source
mBio, 2022 Previous studies suggest that short peptides from the heptad repeat 2 (HR2) domain of gp41 expressed on the cell surface are more potent inhibitors of HIV-1 entry than soluble analogs.
Alexandra Maslennikova +9 more
doaj +1 more source
Atomic structure of a thermostable subdomain of HIV-1 gp41 [PDF]
Proceedings of the National Academy of Sciences, 1997 Infection by HIV-1 involves the fusion of viral and cellular membranes with subsequent transfer of viral genetic material into the cell. The HIV-1 envelope glycoprotein that mediates fusion consists of the surface subunit gp120 and the transmembrane subunit gp41.
K, Tan, J, Liu, J, Wang, S, Shen, M, Lu
openaire +2 more sources
Journal of Medical Virology, Volume 98, Issue 5, May 2026.ABSTRACT Diagnosing HIV‐1 infection as early as the primary infection is crucial. In this context, we performed a comparative evaluation and agreement analysis of the newly proposed serological assay for the combined detection of total antibodies against HIV and P24 antigen (HIV VIDAS® DUO AG/AB, bioMérieux®), with the previously available HIV VIDAS ...
Gilbert Mchantaf +11 more
wiley +1 more source
Development of Protein- and Peptide-Based HIV Entry Inhibitors Targeting gp120 or gp41
Viruses, 2019 Application of highly active antiretroviral drugs (ARDs) effectively reduces morbidity and mortality in HIV-infected individuals. However, the emergence of multiple drug-resistant strains has led to the increased failure of ARDs, thus calling for the ...
Jing Pu +4 more
doaj +1 more source
Tenofovir, Interferon Pathways, and Mucosal Immunity: Implications for People Living With HIV
American Journal of Reproductive Immunology, Volume 95, Issue 5, May 2026.ABSTRACT Background Antiretroviral therapy (ART) suppresses HIV replication and protects people living with HIV (PLWH) from progressing to AIDS. However, despite ART, many PLWH experience chronic immune activation, which contributes to premature aging and non‐AIDS‐related comorbidities. One reason for this chronic immune activation (CIA) is HIV and its
Florian Hladik +5 more
wiley +1 more source