Results 41 to 50 of about 13,547 (178)

ZDHHC18‐Mediated Palmitoylation of ORF3a Promotes SARS‐CoV‐2 Pathogenesis by Antagonizing TRIM16‐Mediated Ubiquitination and Proteasomal Degradation

Advanced Science, Volume 13, Issue 43, 3 August 2026.
Palmitoylation by ZDHHC18 blocks ORF3a K27‐linked ubiquitination mediated by TRIM16, thereby preventing its proteasomal degradation and strengthening viral pathogenesis. Targeting palmitoylation through a pharmacological inhibitor (2‐BP), a competitive inhibitory peptide (OPIP), or adenovirus‐mediated knockdown of ZDHHC18 expression presents a ...
Sidi Yang, Kun Li, Lihong Liu, Linsen Zeng, Qifeng Deng, Jiacheng Huang, Xiaoran Dong, Xin Wang, Jianwei Liang, Hongchao Liu, Hong Peng, Yuxin Lin, Xiaolu Xie, Yuzhen Ye, Tiefeng Xu, Zhaohuan Wang, Chun‐Mei Li, Deyin Guo   +17 more
wiley   +1 more source

Engineering T-Cell Resistance to HIV-1 Infection via Knock-In of Peptides from the Heptad Repeat 2 Domain of gp41

mBio, 2022
Previous studies suggest that short peptides from the heptad repeat 2 (HR2) domain of gp41 expressed on the cell surface are more potent inhibitors of HIV-1 entry than soluble analogs.
Alexandra Maslennikova, Natalia Kruglova, Svetlana Kalinichenko, Dmitriy Komkov, Mikhail Shepelev, Dmitriy Golubev, Andrei Siniavin, Andrei Vzorov, Alexander Filatov, Dmitriy Mazurov   +9 more
doaj   +1 more source

HIV-1 gp41 Fusion Intermediate: A Target for HIV Therapeutics

Journal of the Formosan Medical Association, 2010
Human immunodeficiency virus (HIV)-1 infection is initiated by the binding of gp120 envelope glyco-protein to its cell receptor (CD4) and a coreceptor (CXCR4 or CCR5), followed by a series of conformational changes in the gp41 transmembrane subunit ...
Chungen Pan, Shuwen Liu, Shibo Jiang
doaj   +1 more source

Identification of a human protein-derived HIV-1 fusion inhibitor targeting the gp41 fusion core structure. [PDF]

PLoS ONE, 2013
The HIV-1 envelope glycoprotein (Env) gp41 plays a crucial role in the viral fusion process. The peptides derived from the C-terminal heptad repeat (CHR) of gp41 are potent HIV fusion inhibitors. However, the activity of these anti-HIV-1 peptides in vivo
Lijun Chao, Lu Lu, Hengwen Yang, Yun Zhu, Yuan Li, Qian Wang, Xiaowen Yu, Shibo Jiang, Ying-Hua Chen   +8 more
doaj   +1 more source

AlphaFold2‐Guided Cyclic Peptide Stabilizer Design to Target Protein–Protein Interactions

Proteins: Structure, Function, and Bioinformatics, Volume 94, Issue 7, Page 1356-1370, July 2026.
ABSTRACT The control and modulation of protein–protein interactions (PPIs) is of central importance for the majority of biological processes and most biomedical applications. Stabilization of PPIs, besides inhibition, is of growing pharmaceutical interest.
Niklas Halbwedl, Martin Zacharias
wiley   +1 more source

Bacterial Extracellular Vesicles (BEVs) Derived from Chryseobacterium Inhibit Dengue Virus Infection by Disrupting Its Structural Integrity

Journal of Extracellular Vesicles, Volume 15, Issue 6, June 2026.
This study elucidates a novel antiviral mechanism of bacterial BEVs, which are shown to inactivate viruses by triggering membrane fusion, subsequent lysis and causing structural collapse. This direct virucidal action presents a promising broad‐spectrum strategy against diverse enveloped viruses.
Yaqi Gao, Lijian Zhang, Tianci Zhang, Qiufeng Yao, Ruifang Gao, Yue Wang, Yunpeng Zhao, Tingting Zhou, Jikuai Chen, Xing Zhang, Hao Ren, Yongzhe Zhu, Ping Zhao, Zhongtian Qi, Li Luo, Zhaoling Qin   +15 more
wiley   +1 more source

Model for the structure of the HIV gp41 ectodomain: insight into the intermolecular interactions of the gp41 loop

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 2001
In human immunodeficiency virus (HIV) the viral envelope proteins gp41 and gp120 form a non-covalent complex, which is a potential target for AIDS therapies. In addition gp41 plays a possible role in HIV infection of B cells via the complement system.
openaire   +2 more sources

Development of Protein- and Peptide-Based HIV Entry Inhibitors Targeting gp120 or gp41

Viruses, 2019
Application of highly active antiretroviral drugs (ARDs) effectively reduces morbidity and mortality in HIV-infected individuals. However, the emergence of multiple drug-resistant strains has led to the increased failure of ARDs, thus calling for the ...
Jing Pu, Qian Wang, Wei Xu, Lu Lu, Shibo Jiang   +4 more
doaj   +1 more source

Engineering Pseudomonas protegens as a Targeted Antifungal‐Effector Delivery Chassis via Heterologous Type III Secretion System Reconstitution

Microbial Biotechnology, Volume 19, Issue 6, June 2026.
A heterologous T3SS turns Pseudomonas protegens Pf‐5 into a programmable molecular syringe that delivers Bg9562 into Fusarium hyphae, suppresses fungal pathogens, enhances rhizosphere colonization and protects tomato plants from wilt. This modular platform offers a transferable strategy for next‐generation fungal biocontrol.
Yuyuan Peng, Simei He, Guofan Zhang, Jiatao Yang, Rong Fan, Chen Li, Jiajie Xie, Xinran Long, Linger Qian, Jiayi Wang, Yanmin He, Hui Cai, Yushan Zhang, Qiuqian Zhang, Shaopeng Pan, Shengbiao Hu   +15 more
wiley   +1 more source

A Comprehensive Analysis of the T and B Lymphocytes Repertoire Shaped by HIV Vaccines

Frontiers in Immunology, 2018
The exploitation of various human immunodeficiency virus type-1 (HIV-1) vaccines has posed great challenges for the researchers in precisely evaluating the vaccine-induced immune responses, however, the understanding of vaccination response suffers from ...
Longlong Wang, Longlong Wang, Longlong Wang, Wei Zhang, Wei Zhang, Liya Lin, Liya Lin, Xiao Li, Xiao Li, Nitin K. Saksena, Nitin K. Saksena, Jinghua Wu, Jinghua Wu, Shiyu Wang, Shiyu Wang, Shiyu Wang, Joseph G. Joyce, Xiuqing Zhang, Xiuqing Zhang, Huanming Yang, Huanming Yang, Jian Wang, Jian Wang, I-Ming Wang, Xiao Liu, Xiao Liu   +25 more
doaj   +1 more source