Results 21 to 30 of about 13,547 (178)
Allosteric modulation of the HIV-1 gp120-gp41 association site by adjacent gp120 variable region 1 (V1) N-glycans linked to neutralization sensitivity. [PDF]
PLoS Pathogens, 2013 The HIV-1 gp120-gp41 complex, which mediates viral fusion and cellular entry, undergoes rapid evolution within its external glycan shield to enable escape from neutralizing antibody (NAb).
Heidi E Drummer +6 more
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Design and Properties of NCCG-gp41, a Chimeric gp41 Molecule with Nanomolar HIV Fusion Inhibitory Activity [PDF]
Journal of Biological Chemistry, 2001 The design and characterization of a chimeric protein, termed N(CCG)-gp41, derived from the ectodomain of human immunodeficiency virus (HIV), type I gp41 is described. N(CCG)-gp41 features an exposed trimeric coiled-coil comprising the N-terminal helices of the gp41 ectodomain.
J M, Louis, C A, Bewley, G M, Clore
openaire +2 more sources
PLoS Pathogens, 2010 The HIV-1 envelope glycoprotein (Env) composed of the receptor binding domain gp120 and the fusion protein subunit gp41 catalyzes virus entry and is a major target for therapeutic intervention and for neutralizing antibodies.
Victor Buzon +5 more
doaj +1 more source
Sub-inhibitory concentrations of human α-defensin potentiate neutralizing antibodies against HIV-1 gp41 pre-hairpin intermediates in the presence of serum. [PDF]
PLoS Pathogens, 2013 Human defensins are at the forefront of the host responses to HIV and other pathogens in mucosal tissues. However, their ability to inactivate HIV in the bloodstream has been questioned due to the antagonistic effect of serum.
Lusine Demirkhanyan +3 more
doaj +1 more source
PLoS ONE, 2016 The objective of this study was to extend our previous research and to further characterize the humoral immune responses against HIV-1 p24, gp41 and the specific peptides carrying the immunodominant epitopes (IDEs) that react with human serum samples ...
Xiufen Li +6 more
doaj +1 more source
Retrovirology, 2012 Background The mechanism by which HIV-1 induces AIDS is still unknown. Previously, synthetic peptides corresponding to the conserved immunosuppressive (isu) domain in gp41 of HIV-1 had been shown to inhibit proliferation and to modulate cytokine ...
Morozov Vladimir A +3 more
doaj +1 more source
Antiviral Activities of HIV-1-Specific Human Broadly Neutralizing Antibodies Are Isotype-Dependent
Vaccines, 2022 Broadly neutralizing antibodies (bNAbs) offer promising opportunities for preventing HIV-1 infection. The protection mechanisms of bNAbs involve the Fc domain, as well as their Fab counterpart.
Blandine Noailly +7 more
doaj +1 more source
Nature Medicine, 2004 The first X-ray crystal structures of gp41, the protein that mediates fusion of HIV-1 to target cells, were solved in the mid-1990s. The structures provide a foundation for understanding viral entry and the mechanism of action of compounds that block fusion.
Zwick, Michael B +2 more
openaire +1 more source
Evolution of the HIV-1 envelope glycoproteins with a disulfide bond between gp120 and gp41
Retrovirology, 2004 Background We previously described the construction of an HIV-1 envelope glycoprotein complex (Env) that is stabilized by an engineered intermolecular disulfide bond (SOS) between gp120 and gp41.
Caffrey Michael +5 more
doaj +1 more source
Retrovirology, 2010 Background The sequences of membrane-spanning domains (MSDs) on the gp41 subunit are highly conserved among many isolates of HIV-1. The GXXXG motif, a potential helix-helix interaction motif, and an arginine residue (rare in hydrophobic MSDs) are ...
Kondo Naoyuki +6 more
doaj +1 more source