Results 21 to 30 of about 13,523 (178)

Identification of HIV gp41-specific antibodies that mediate killing of infected cells.

PLoS Pathogens, 2019
Antibodies that mediate killing of HIV-infected cells through antibody-dependent cellular cytotoxicity (ADCC) have been implicated in protection from HIV infection and disease progression.
Katherine L Williams, Megan Stumpf, Nicole Elise Naiman, Shilei Ding, Meghan Garrett, Theodore Gobillot, Dani Vézina, Katharine Dusenbury, Nitya S Ramadoss, Ryan Basom, Peter S Kim, Andrés Finzi, Julie Overbaugh   +12 more
doaj   +1 more source

IGHV1-69 B cell chronic lymphocytic leukemia antibodies cross-react with HIV-1 and hepatitis C virus antigens as well as intestinal commensal bacteria. [PDF]

PLoS ONE, 2014
B-cell chronic lymphocytic leukemia (B-CLL) patients expressing unmutated immunoglobulin heavy variable regions (IGHVs) use the IGHV1-69 B cell receptor (BCR) in 25% of cases.
Kwan-Ki Hwang, Ashley M Trama, Daniel M Kozink, Xi Chen, Kevin Wiehe, Abby J Cooper, Shi-Mao Xia, Minyue Wang, Dawn J Marshall, John Whitesides, Munir Alam, Georgia D Tomaras, Steven L Allen, Kanti R Rai, Jane McKeating, Rosa Catera, Xiao-Jie Yan, Charles C Chu, Garnett Kelsoe, Hua-Xin Liao, Nicholas Chiorazzi, Barton F Haynes   +21 more
doaj   +1 more source

Alanine Scanning Mutants of the HIV gp41 Loop [PDF]

Journal of Biological Chemistry, 2005
Based on mutagenesis and structural studies of human immunodeficiency virus (HIV) envelope proteins, the loop region of gp41 is thought to directly interact with gp120. The importance of the HIV gp41 loop region to envelope function has been systematically examined by alanine scanning of all gp41 loop residues and the subsequent characterization of the
Amy, Jacobs, Jayita, Sen, Lijun, Rong, Michael, Caffrey   +3 more
openaire   +2 more sources

Characterization of Humoral Immune Responses against Capsid Protein p24 and Transmembrane Glycoprotein gp41 of Human Immunodeficiency Virus Type 1 in China.

PLoS ONE, 2016
The objective of this study was to extend our previous research and to further characterize the humoral immune responses against HIV-1 p24, gp41 and the specific peptides carrying the immunodominant epitopes (IDEs) that react with human serum samples ...
Xiufen Li, Yue Wu, Xuqi Ren, Shuyun Deng, Guifang Hu, Shouyi Yu, Shixing Tang   +6 more
doaj   +1 more source

Allosteric modulation of the HIV-1 gp120-gp41 association site by adjacent gp120 variable region 1 (V1) N-glycans linked to neutralization sensitivity. [PDF]

PLoS Pathogens, 2013
The HIV-1 gp120-gp41 complex, which mediates viral fusion and cellular entry, undergoes rapid evolution within its external glycan shield to enable escape from neutralizing antibody (NAb).
Heidi E Drummer, Melissa K Hill, Anne L Maerz, Stephanie Wood, Paul A Ramsland, Johnson Mak, Pantelis Poumbourios   +6 more
doaj   +1 more source

Sub-inhibitory concentrations of human α-defensin potentiate neutralizing antibodies against HIV-1 gp41 pre-hairpin intermediates in the presence of serum. [PDF]

PLoS Pathogens, 2013
Human defensins are at the forefront of the host responses to HIV and other pathogens in mucosal tissues. However, their ability to inactivate HIV in the bloodstream has been questioned due to the antagonistic effect of serum.
Lusine Demirkhanyan, Mariana Marin, Wuyuan Lu, Gregory B Melikyan   +3 more
doaj   +1 more source

Antiviral Activities of HIV-1-Specific Human Broadly Neutralizing Antibodies Are Isotype-Dependent

Vaccines, 2022
Broadly neutralizing antibodies (bNAbs) offer promising opportunities for preventing HIV-1 infection. The protection mechanisms of bNAbs involve the Fc domain, as well as their Fab counterpart.
Blandine Noailly, Melyssa Yaugel-Novoa, Justine Werquin, Fabienne Jospin, Daniel Drocourt, Thomas Bourlet, Nicolas Rochereau, Stéphane Paul   +7 more
doaj   +1 more source

Crystal structure of HIV-1 gp41 including both fusion peptide and membrane proximal external regions.

PLoS Pathogens, 2010
The HIV-1 envelope glycoprotein (Env) composed of the receptor binding domain gp120 and the fusion protein subunit gp41 catalyzes virus entry and is a major target for therapeutic intervention and for neutralizing antibodies.
Victor Buzon, Ganesh Natrajan, David Schibli, Felix Campelo, Michael M Kozlov, Winfried Weissenhorn   +5 more
doaj   +1 more source

Single mutations in the transmembrane envelope protein abrogate the immunosuppressive property of HIV-1

Retrovirology, 2012
Background The mechanism by which HIV-1 induces AIDS is still unknown. Previously, synthetic peptides corresponding to the conserved immunosuppressive (isu) domain in gp41 of HIV-1 had been shown to inhibit proliferation and to modulate cytokine ...
Morozov Vladimir A, Morozov Alexey V, Semaan Marwan, Denner Joachim   +3 more
doaj   +1 more source

The membrane-spanning domain of gp41 plays a critical role in intracellular trafficking of the HIV envelope protein

Retrovirology, 2010
Background The sequences of membrane-spanning domains (MSDs) on the gp41 subunit are highly conserved among many isolates of HIV-1. The GXXXG motif, a potential helix-helix interaction motif, and an arginine residue (rare in hydrophobic MSDs) are ...
Kondo Naoyuki, Long Yufei, Curran A Rachael, Miyauchi Kosuke, Iwamoto Aikichi, Engelman Donald M, Matsuda Zene   +6 more
doaj   +1 more source