Results 101 to 110 of about 957,254 (314)
Molecular Oncology, EarlyView.We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala +15 more
wiley +1 more source
Fiberoptics technology and its application to propulsion control systems [PDF]
Electro-optical systems have many advantages over conventional electrical systems. Among these are optics' insensitivity to electro-magnetic interference, good electrical isolation and the ability to make measurements in highly explosive areas without ...
Baumbick, R. J.
core +1 more source
Molecular Oncology, EarlyView.Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang +3 more
wiley +1 more source
DEAN: A program for dynamic engine analysis [PDF]
The Dynamic Engine Analysis program, DEAN, is a FORTRAN code implemented on the IBM/370 mainframe at NASA Lewis Research Center for digital simulation of turbofan engine dynamics.
Melcher, K. J., Sadler, G. G.
core +1 more source
A retrospective view on the promise on machine translation for Bahasa Melayu-English [PDF]
, 2010 Research and development activities for machine translation systems from English language to others are more progressive than vice versa. It has been more than 30 years since the machine translation was introduced and yet a Malay language or Bahasa ...
Jamaludin, Zulikha +2 more
core
Implications of Coupling in Quantum Thermodynamic Machines
, 2017 We study coupled quantum systems as the working media of thermodynamic machines. Under a suitable phase-space transformation, the coupled systems can be expressed as a composition of independent subsystems.
Banik, Manik +2 more
core +2 more sources
Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source
Design description of a microprocessor based Engine Monitoring and Control unit (EMAC) for small turboshaft [PDF]
Research programs have demonstrated that digital electronic controls are more suitable for advanced aircraft/rotorcraft turbine engine systems than hydromechanical controls.
Baez, A. N.
core +1 more source
Molecular Oncology, EarlyView.Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley +5 more
wiley +1 more source
Who needs engine monitoring? [PDF]
Operational evaluations of engine monitoring systems (EMS) are discussed.
Pettigrew, J. L.
core +1 more source