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Site systems engineering: Systems engineering management plan [PDF]

open access: yes, 1996
The Site Systems Engineering Management Plan (SEMP) is the Westinghouse Hanford Company (WHC) implementation document for the Hanford Site Systems Engineering Policy, (RLPD 430.1) and Systems Engineering Criteria Document and Implementing Directive, (RLID 430.1).
openaire   +2 more sources

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

Influence of Quenching Height and Air Distribution Ratio on Combustion Characteristics of RQL Combustor

open access: yesShanghai Jiaotong Daxue xuebao
Based on the principle of the rich-burn/quench/lean-burn (RQL) technology, a low emission combustion chamber for gas turbine was designed. The effects of different heights of quenching structure and distribution ratios of the air flow on the flow field ...
HUI Lei, LIU Aiguo, WU Xiaoqu, ZHANG Yunjie, ZENG Wen
doaj   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

A comprehensive aerodynamic-thermal-mechanical design method for fast response turbocharger applied in aviation piston engines

open access: yesPropulsion and Power Research
Limited by the poor transient response performance of turbochargers, the dynamic performance of aviation piston engines tends to deteriorate. In a bid to enhance the turbocharger's acceleration capabilities, this study scrutinizes various factors ...
Yu Zhou   +7 more
doaj   +1 more source

Effects of injection pressure and impingement distance on flat-wall impinging spray flame and its heat flux under diesel engine-like condition

open access: yesAdvances in Mechanical Engineering, 2019
Heat loss is one of the main causes of energy losses in modern direct injection diesel engines. This heat loss of the engine occurs during combustion, mainly due to the heat transfer between the impinging spray flame and the piston cavity wall.
Rizal Mahmud   +5 more
doaj   +1 more source

Structural biology of ferritin nanocages

open access: yesFEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

open access: yesMolecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou   +5 more
wiley   +1 more source

PROSPECTS OF DEVELOPMENT ELECTRONIC AUTOMATIC CONTROL SYSTEMS FOR GAS-TURBINE ENGINES

open access: yesАвіаційно-космічна техніка та технологія, 2018
The analysis of the basic directions of electronic automatic control systems for aviation gas-turbine engines (FADEC) development is presented. This analysis is executed on the base of materials of the Scientific and Technical Congress of Aero-Engine ...
Геннадий Степанович Ранченко   +1 more
doaj   +1 more source

Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology

open access: yesMolecular Oncology, EarlyView.
Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts   +8 more
wiley   +1 more source

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