Results 31 to 40 of about 82,857 (303)
Advances in Cardiac Tissue Engineering
Bioengineering, 2022 Tissue engineering has paved the way for the development of artificial human cardiac muscle patches (hCMPs) and cardiac tissue analogs, especially for treating Myocardial infarction (MI), often by increasing its regenerative abilities. Low engraftment rates, insufficient clinical application scalability, and the creation of a functional vascular system
Takahiro Kitsuka +7 more
openaire +3 more sources
Stem Cells International, 2017 Insulin-like growth factor 1 (IGF1) and neuregulin-1β (NRG1) play important roles during cardiac development both individually and synergistically. In this study, we analyze how 3D cardiac tissue engineered from human embryonic stem cell- (hESC-) derived
Cassady E. Rupert, Kareen L. K. Coulombe
doaj +1 more source
Implantation of a poly-L-lactide GCSF-functionalized scaffold in a model of chronic myocardial infarction [PDF]
, 2017 A previously developed poly-l-lactide scaffold releasing granulocyte colony-stimulating factor (PLLA/GCSF) was tested in a rabbit chronic model of myocardial infarction (MI) as a ventricular patch.
Chello, Massimo +10 more
core +1 more source
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2020 Background To understand the intrinsic cardiac developmental and functional abnormalities in pulmonary atresia with intact ventricular septum (PAIVS) free from effects secondary to anatomic defects, we performed and compared single‐cell transcriptomic ...
Yin‐Yu Lam +7 more
doaj +1 more source
Recent Advances on Electroconductive Hydrogels Used in Heart Repair and Regeneration
Advances in Materials Science and Engineering, 2022 Myocardial infarction (MI) permanently damages cardiac tissue. Tissue engineering exhibits tremendous potential as a strategy for developing engineered tissue to repair congenital abnormalities in the heart and/or cardiovascular tissue. Electroconductive
Xu Yan, Huan Sun, Ping Yang
doaj +1 more source
Nanopatterned acellular valve conduits drive the commitment of blood-derived multipotent cells [PDF]
, 2016 Considerable progress has been made in recent years toward elucidating the correlation among nanoscale topography, mechanical properties, and biological behavior of cardiac valve substitutes.
Aguiari, Paola +11 more
core +2 more sources
Stem Cells International, 2021 Background. Human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) are under preclinical investigation as a cell-based therapy for heart failure post-myocardial infarction.
Ikeotunye Royal Chinyere +9 more
doaj +1 more source
Gene Transfer of Engineered Calmodulin Alleviates Ventricular Arrhythmias in a Calsequestrin-Associated Mouse Model of Catecholaminergic Polymorphic Ventricular Tachycardia [PDF]
, 2018 Catecholaminergic polymorphic ventricular tachycardia (CPVT) is a familial arrhythmogenic syndrome characterized by sudden death. There are several genetic forms of CPVT associated with mutations in genes encoding the cardiac ryanodine receptor (RyR2 ...
Belevych, Andriy E +12 more
core +1 more source
Scientific Reports, 2018 Cardiac tissue engineering, which combines cells and supportive scaffolds, is an emerging treatment for restoring cardiac function after myocardial infarction (MI), although, the optimal construct remains a challenge.
Isaac Perea-Gil +12 more
doaj +1 more source
Traction force microscopy of engineered cardiac tissues. [PDF]
PLoS ONE, 2018 Cardiac tissue development and pathology have been shown to depend sensitively on microenvironmental mechanical factors, such as extracellular matrix stiffness, in both in vivo and in vitro systems.
Francesco Silvio Pasqualini +5 more
doaj +1 more source