Engineered Macroscale Cardiac Constructs Elicit Human Myocardial Tissue-like Functionality
Stem Cell Reports, 2019 Summary: In vitro surrogate models of human cardiac tissue hold great promise in disease modeling, cardiotoxicity testing, and future applications in regenerative medicine.
Maria Valls-Margarit +13 more
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Cell-based gene therapy for mending infarcted hearts [PDF]
, 2011 The goal of this study was to analyse the efficiency of a combinatorial cell/growth factor therapy to improve function of infarcted murine hearts. The Insulin-like Growth Factor-1 (IGF-1) isoform, IGF-1Ea, has been shown to reduce scar formation and ...
Poudel, Bhawana, Poudel, Bhawana
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Therapeutic Potential of Mesenchymal Stem Cells for Cancer Therapy [PDF]
, 2020 Mesenchymal stem cells (MSCs) are among the most frequently used cell type for regenerative medicine. A large number of studies have shown the beneficial effects of MSC-based therapies to treat different pathologies, including neurological disorders ...
Capilla González, Vivian +4 more
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Patient and Disease-Specific Induced Pluripotent Stem Cells for Discovery of Personalized Cardiovascular Drugs and Therapeutics. [PDF]
, 2020 Human induced pluripotent stem cells (iPSCs) have emerged as an effective platform for regenerative therapy, disease modeling, and drug discovery.
Chandy, Mark +2 more
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The light and shadow of senescence and inflammation in cardiovascular pathology and regenerative medicine [PDF]
, 2017 Recent epidemiologic studies evidence a dramatic increase of cardiovascular diseases, especially associated with the aging of the world population. During aging, the progressive impairment of the cardiovascular functions results from the compromised ...
Cavarretta, Elena +9 more
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Cardiac Conduction through Engineered Tissue [PDF]
The American Journal of Pathology, 2006 In children, interruption of cardiac atrioventricular (AV) electrical conduction can result from congenital defects, surgical interventions, and maternal autoimmune diseases during pregnancy. Complete AV conduction block is typically treated by implanting an electronic pacemaker device, although long-term pacing therapy in pediatric patients has ...
Yeong-Hoon, Choi +14 more
openaire +2 more sources
Mesenchymal stem cells as vectors for lung cancer therapy [PDF]
, 2013 Despite recent advances in treatment, lung cancer accounts for one third of all cancer-related deaths, underlining the need of development of new therapies.
Janes, SM, Kolluri, KK, Laurent, GJ
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Naturally Engineered Maturation of Cardiomyocytes
Frontiers in Cell and Developmental Biology, 2017 Ischemic heart disease remains one of the most prominent causes of mortalities worldwide with heart transplantation being the gold-standard treatment option.
Gaetano J. Scuderi, Jonathan Butcher
doaj +1 more source
Two dimensional electrophysiological characterization of human pluripotent stem cell-derived cardiomyocyte system. [PDF]
, 2017 Stem cell-derived cardiomyocytes provide a promising tool for human developmental biology, regenerative therapies, disease modeling, and drug discovery.
Gimzewski, James K +7 more
core +2 more sources
Artificial Scaffolds in Cardiac Tissue Engineering
Life, 2022 Cardiovascular diseases are a leading cause of death worldwide. Current treatments directed at heart repair have several disadvantages, such as a lack of donors for heart transplantation or non-bioactive inert materials for replacing damaged tissue.
Jorge A. Roacho-Pérez +11 more
openaire +3 more sources