Patient and Disease-Specific Induced Pluripotent Stem Cells for Discovery of Personalized Cardiovascular Drugs and Therapeutics. [PDF]
, 2020 Human induced pluripotent stem cells (iPSCs) have emerged as an effective platform for regenerative therapy, disease modeling, and drug discovery.
Chandy, Mark +2 more
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Therapeutic Potential of Mesenchymal Stem Cells for Cancer Therapy [PDF]
, 2020 Mesenchymal stem cells (MSCs) are among the most frequently used cell type for regenerative medicine. A large number of studies have shown the beneficial effects of MSC-based therapies to treat different pathologies, including neurological disorders ...
Capilla González, Vivian +4 more
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Virtual cardiac monolayers for electrical wave propagation [PDF]
, 2017 The complex structure of cardiac tissue is considered to be one of the main determinants of an arrhythmogenic substrate. This study is aimed at developing the first mathematical model to describe the formation of cardiac tissue, using a joint in silico ...
Agladze, Konstantin +3 more
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Cardiac Conduction through Engineered Tissue [PDF]
The American Journal of Pathology, 2006 In children, interruption of cardiac atrioventricular (AV) electrical conduction can result from congenital defects, surgical interventions, and maternal autoimmune diseases during pregnancy. Complete AV conduction block is typically treated by implanting an electronic pacemaker device, although long-term pacing therapy in pediatric patients has ...
Yeong-Hoon, Choi +14 more
openaire +2 more sources
The light and shadow of senescence and inflammation in cardiovascular pathology and regenerative medicine [PDF]
, 2017 Recent epidemiologic studies evidence a dramatic increase of cardiovascular diseases, especially associated with the aging of the world population. During aging, the progressive impairment of the cardiovascular functions results from the compromised ...
Cavarretta, Elena +9 more
core +4 more sources
Noninvasive assessment of an engineered bioactive graft in myocardial infarction: impact on cardiac function and scar healing [PDF]
, 2016 Cardiac tissue engineering, which combines cells and biomaterials, is promising for limiting the sequelae of myocardial infarction (MI). We assessed myocardial function and scar evolution after implanting an engineered bioactive impedance graft (EBIG) in
Bayés Genis, Antoni +11 more
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Naturally Engineered Maturation of Cardiomyocytes
Frontiers in Cell and Developmental Biology, 2017 Ischemic heart disease remains one of the most prominent causes of mortalities worldwide with heart transplantation being the gold-standard treatment option.
Gaetano J. Scuderi, Jonathan Butcher
doaj +1 more source
Mesenchymal stem cells as vectors for lung cancer therapy [PDF]
, 2013 Despite recent advances in treatment, lung cancer accounts for one third of all cancer-related deaths, underlining the need of development of new therapies.
Janes, SM, Kolluri, KK, Laurent, GJ
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Computational fluid dynamic analysis of bioprinted self-supporting perfused tissue models [PDF]
, 2020 Natural tissues are incorporated with vasculature, which is further integrated with a cardiovascular system responsible for driving perfusion of nutrient‐rich oxygenated blood through the vasculature to support cell metabolism within most cell‐dense ...
Bonewald, Lynda F. +8 more
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Artificial Scaffolds in Cardiac Tissue Engineering
Life, 2022 Cardiovascular diseases are a leading cause of death worldwide. Current treatments directed at heart repair have several disadvantages, such as a lack of donors for heart transplantation or non-bioactive inert materials for replacing damaged tissue.
Jorge A. Roacho-Pérez +11 more
openaire +3 more sources