Results 71 to 80 of about 1,238,092 (290)

Examining the issues & challenges of email & e-communications. 2nd Northumbria Witness Seminar Conference, 24-25 Oct 2007 Northumbria University, Newcastle upon Tyne. [PDF]

open access: yes, 2008
These proceedings capture the content of the second Witness Seminar hosted by Northumbria University’s School of Computing, Engineering and Information Sciences.
Childs, Sue   +4 more
core  

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

open access: yesFEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva   +10 more
wiley   +1 more source

A hierarchy model on the research fields of cyberspace security technology

open access: yes网络与信息安全学报, 2015
Cyberspace security is an interdisciplinary subject involved with computer science and technology,in-formation and communication engineering,control science and engineering and cryptography.It has an explicit and in-depth discipline connotation.First,the
Bin-xing FANG
doaj   +3 more sources

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

Explaining the AMST Model: Using Arts, Maths, Science, and Technology in an Upgraded Problem-Based Learning Approach [PDF]

open access: yesJournal of Systemics, Cybernetics and Informatics, 2017
Recent literature has touted the importance of the Science, Technology, Engineering, and Mathematics (STEM) curriculum model as the best way to develop a problem-based inquiry in the technology-rich, globally-connected 21st century learning environment ...
Georgia Daleure
doaj  

Big Data and cloud computing: innovation opportunities and challenges

open access: yesInternational Journal of Digital Earth, 2017
Big Data has emerged in the past few years as a new paradigm providing abundant data and opportunities to improve and/or enable research and decision-support applications with unprecedented value for digital earth applications including business ...
Chaowei Yang   +4 more
doaj   +1 more source

Digital, material and networked: some emerging themes for SET education [PDF]

open access: yes, 2015
Boundaries between the digital and material worlds are becoming blurred as the internet increasingly connects us to things as well as people and information.
Davies, Sarah-Jane   +2 more
core  

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

open access: yesFEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson   +7 more
wiley   +1 more source

Meaning and Vision of Mimic Computing and Mimic Security Defense

open access: yesDianxin kexue, 2014
To facilitate high-performance and high-security computing, a technology system based on mimic computing(MC)and mimic security defense(MSD)was proposed. The proposed system focused on both the multi-dimensional reconfigurable and functional architecture ...
Jiangxing Wu
doaj   +2 more sources

Design and Realization of Brake System in Heavy Engineering Vehicle based on Web Theory

open access: yesJixie chuandong, 2015
In order to solve the problems of the design and simulation analysis software portability and interoperability deficiencies of existing heavy engineering vehicle brake system,by using the Browser/Server and Client/Server hybrid structure,combined the JSP.
Ma Zhanbao, Wang Jing
doaj  

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