Results 51 to 60 of about 1,008,712 (292)
Weight–strength optimization of wooden household chairs based on member section size
Maderas: Ciencia y Tecnología, 2022 Weight-strength optimization of wooden household chairs was performed based on the member section size in this study. Member section sizes of the Scotch pine (Pinus sylvestris) and Oriental beech (Fagus orientalis) chairs were optimized and resulting re-
Ersan Güray, Erkan Ceylan, Ali Kasal
doaj
A practical application for machine design education
Journal of Advanced Mechanical Design, Systems, and Manufacturing, 2018 Machine design is perhaps the most important course for Mechanical Engineering students. There are many diverse approaches to the design education in universities worldwide.
Hüseyin R. BÖRKLÜ +3 more
doaj +1 more source
FEBS Letters, EarlyView.The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li +2 more
wiley +1 more source
FEBS Letters, EarlyView.We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee +3 more
wiley +1 more source
South African Journal of Industrial Engineering, 2016 This paper synthesises an overview of various models of the engineering design process with an overview of the most relevant theories within the field of creativity studies to conclude that (i) creativity plays a role throughout the engineering design ...
Oosthuizen, L., Vlok, P. J.
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Maps, Mirrors, and Participants: Design Lenses for Sociomateriality in\n Engineering Organizations [PDF]
, 2020 Edward Burnell +2 more
openalex +1 more source
Structural biology of ferritin nanocages
FEBS Letters, EarlyView.Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley +1 more source
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
Supply-Demand-Based Optimization: A Novel Economics-Inspired Algorithm for Global Optimization
IEEE Access, 2019 A novel metaheuristic optimization algorithm, named supply-demand-based optimization (SDO), is presented in this paper. SDO is a swarm-based optimizer motivated by the supply-demand mechanism in economics.
Weiguo Zhao, Liying Wang, Zhenxing Zhang
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Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source